A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction

Journal of Biomolecular Screening

Volumn 16, Issue 4, 2011, Pages 450-456

  Li, Jing ^a   Zhang, Shuyong ^a   Gao, Linghuan ^a   Chen, Ying ^a   Xie, Xin ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

high throughput screening; MDM2; p53; protein protein interaction; small molecule inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; LUCIFERASE; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53;

ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; FALSE POSITIVE RESULT; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM;

CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA;

EID: 79955383140     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111399191     Document Type: Article

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