Enantioselective total synthesis of (+)-gliocladine C: Convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors

Journal of the American Chemical Society

Volumn 133, Issue 17, 2011, Pages 6549-6552

  Delorbe, John E ^a   Jabri, Salman Y ^a   Mennen, Steven M ^a,b   Overman, Larry E ^a   Zhang, Fang Li ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AMGEN INC   (United States)

^c Suzhou Novartis Pharma Technology Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVE TOTAL SYNTHESIS; GENERAL APPROACH; NATURAL PRODUCTS; PYRROLIDINE RINGS; QUATERNARY CARBON; STEREOCENTERS; TOTAL SYNTHESIS;

BIOCHEMISTRY;

ALKALOID; CYCLOTRYPTAMINE; EPIDITHIODIOXOPIPERAZINE; GLIOCLADINE C; PIPERAZINE DERIVATIVE; POLYOXOPIPERAZINE; PYRROLIDINE DERIVATIVE; TRIOXOPIPERAZINE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; FUNGI; ISATIN; PIPERAZINES; PYRROLIDINONES; STEREOISOMERISM;

EID: 79955369063     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201789v     Document Type: Article

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