Melatonin protects mice with intermittent hypoxia from oxidative stress-induced pancreatic injury

Sleep and Biological Rhythms

Volumn 9, Issue 2, 2011, Pages 78-85

  Li, Guang ^a   Hou, Gang ^a   Lu, Wei ^a   Kang, Jian ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Intermittent hypoxia; Melatonin; Oxidative stress; Pancreas

Indexed keywords

GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; INSULIN; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MELATONIN; MESSENGER RNA; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPOXIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS INJURY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SLEEP APNEA SYNDROME;

EID: 79955136616     PISSN: 14469235     EISSN: 14798425     Source Type: Journal    
DOI: 10.1111/j.1479-8425.2011.00486.x     Document Type: Article

References (37)

1. Shaw JE, Punjabi NM, Wilding JP etal. Sleep-disordered breathing and type 2 diabetes A report from the International Diabetes Federation Taskforce on Epidemiology and Prevention. Diabetes Res. Clin. Pract. 2008; 81: 2-12.
2. Idris I, Hall AP, O'Reilly J etal. Obstructive sleep apnoea in patients with type 2 diabetes: aetiology and implications for clinical care. Diabetes Obes. Metab. 2009; 11: 733-41.
3. Tasali E, Mokhlesi B, Van Cauter E. Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest 2008; 133: 496-506.
4. Larsen JJ, Hansen JM, Olsen NV etal. The effect of altitude hypoxia on glucose homeostasis in men. J. Physiol. 1997; 504: (Pt 1): 241-9.
5. Braun B, Rock PB, Zamudio S etal. Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity. J. Appl. Physiol. 2001; 91: 623-31.
6. Oltmanns KM, Gehring H, Rudolf S etal. Hypoxia causes glucose intolerance in humans. Am. J. Respir. Crit. Care Med. 2004; 169: 1231-7.
7. West SD, Nicoll DJ, Wallace TM etal. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 2007; 62: 969-74.
8. Chin K, Shimizu K, Nakamura T etal. Changes in intraabdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999; 100: 706-12.
9. Evans JL, Maddux BA, Goldfine ID. The molecular basis for oxidative stress-induced insulin resistance. Antioxid. Redox Signal. 2005; 7: 1040-52.
10. Kim JE, Kim YW, Lee IK etal. AMPactivated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J. Pharmacol. Sci. 2008; 106: 394-403.
11. Reiter RJ, Tan DX, Maldonado MD. Melatonin as an antioxidant: physiology versus pharmacology. J. Pineal Res. 2005; 39: 215-16.
12. Tan DX, Manchester LC, Terron MP etal. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 2007; 42: 28-42.
13. El-Sokkary GH, Khidr BM, Younes HA. Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice. Eur. J. Pharmcol. 2006; 540: 107-14.
14. Wang WZ, Fang XH, Stephenson LL etal. Melatonin reduces ischemia/reperfusion-induced superoxide generation in arterial wall and cell death in skeletal muscle. J. Pineal Res. 2006; 41: 255-60.
15. Szarszoi O, Asemu G, Vanecek J etal. Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovasc. Drugs Ther. 2001; 15: 251-7.
16. Lee EJ, Lee MY, Chen HY etal. Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J. Pineal Res. 2005; 38: 42-52.
17. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8.
18. Ip MS, Lam B, Ng MM etal. Obstructive sleep apnea is independently associated with insulin resistance. Am. J. Respir. Crit. Care Med. 2002; 165: 670-6.
19. Punjabi NM, Sorkin JD, Katzel LI etal. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am. J. Respir. Crit. Care Med. 2002; 165: 677-82.
20. Punjabi NM, Shahar E, Redline S etal. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 2004; 160: 521-30.
21. Harsch IA, Schahin SP, Radespiel-Troger M etal. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patientswith obstructive sleep apnea syndrome. Am. J. Respir. Crit. Care Med. 2004; 169: 156-62.
22. Furukawa S, Fujita T, Shimabukuro M etal. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004; 114: 1752-61.
23. Laight DW, Desai KM, Gopaul NK etal. Pro-oxidant challenge in vivo provokes the onset of NIDDM in the insulin resistant obese Zucker rat. Br. J. Pharmacol. 1999; 128: 269-71.
24. Eşrefoǧlu M, Gül M, Ateş B etal. Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. J. Pineal Res. 2006; 40: 92-7.
25. Hung MW, Tipoe GL, Poon AM etal. Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J. Pineal Res. 2008; 44: 214-21.
26. Xu J, Long YS, Gozal D etal. β-cell death and proliferation after intermittent hypoxia: role of oxidative stress. Free Radic. Biol. Med. 2009; 46: 783-90.
27. Bülbüller N, Dogru O, Umac H etal. The effects of melatonin and pentoxiphylline on L-arginine induced acute pancreatitis. Ulus. Travma Acil Cerrahi Derg. 2005; 11: 108-14.
28. Konturek SJ, Konturek PC, Brzozowska I etal. Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT). J. Physiol. Pharmacol. 2007; 58: 381-405.
29. Munoz-Casares FC, Padillo FJ, Briceno J etal. Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. J. Pineal Res. 2006; 40: 195-203.
30. Esparza JL, Gomez M, Rosa Nogues M etal. Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats. J. Pineal Res. 2005; 39: 129-36.
31. Tiedge M, Lortz S, Drinkgern J etal. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46: 1733-42.
32. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 1996; 20: 463-6.
33. Al-Delaimy WK, Manson JE, Willett WC etal. Snoring as arisk factor for type II diabetes mellitus: a prospective study. Am. J. Epidemiol. 2002; 155: 387-93.
34. Elmasry A, Janson C, Lindberg E etal. The role of habitual snoring and obesity in the development of diabetes: a 10-year follow-up study in a male population. J. Intern. Med. 2000; 248: 13-20.
35. Chen J, Fontes G, Saxena G etal. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes 2010; 59: 440-7.
36. Bertuglia S, Reiter RJ. Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J. Pineal Res. 2009; 46: 307-13.
37. Polotsky VY, Li J, Punjabi NM etal. Intermittent hypoxia increases insulin resistance in genetically obese mice. J. Physiol. 2003; 552: 253-64.