Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples

Journal of Chromatography A

Volumn 1218, Issue 20, 2011, Pages 3080-3088

  Zeng, Lu ^a   Xu, Rongda ^a   Zhang, Yinong ^a   Kassel, Daniel B ^a  

^a Takeda San Diego Inc   (United States)

Author keywords

Enantioselective method development and optimization; Two dimensional achiral and chiral chromatography; Two dimensional SFC SFC MS

Indexed keywords

BACK PRESSURE REGULATORS; CHIRAL COLUMN; CHIRAL SEPARATIONS; CHROMATOGRAPHIC SEPARATIONS; CHROMATOGRAPHY/MASS SPECTROMETRY; CLEAN UP; COMPLEX MIXTURE; CONTROL SOFTWARE; CUSTOM SOFTWARE PROGRAM; DRUG DISCOVERY; ENANTIOMERIC ANALYSIS; ENANTIOMERIC SEPARATION; ION SIGNALS; ISOCRATIC ELUTION; MASS SPECTROMETRIC DATA; METHOD DEVELOPMENT; RACEMIC COMPOUNDS; REAL TIME; SAMPLE INFORMATION; STARTING MATERIALS; SYSTEM USE; TWO-DIMENSIONAL ACHIRAL AND CHIRAL CHROMATOGRAPHY; TWO-DIMENSIONAL SFC/SFC/MS;

CHIRALITY; COLUMN CHROMATOGRAPHY; COMPUTER SOFTWARE; EFFLUENT TREATMENT; ENANTIOMERS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IMPURITIES; MASS SPECTROMETERS; MASS SPECTROMETRY; OPTIMIZATION; PRESSURE REGULATORS; PUMPS; PURIFICATION; SUPERCRITICAL FLUIDS; VALVES (MECHANICAL);

TWO DIMENSIONAL;

CARBON DIOXIDE;

ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG PURIFICATION; ELUTION; ENANTIOMER; FRACTIONATION; MASS SPECTROMETRY; MOLECULAR WEIGHT; MONITORING; PRESSURE; PRIORITY JOURNAL; PUMP; RACEMIC MIXTURE; SUPERCRITICAL FLUID CHROMATOGRAPHY; VALVE;

CHROMATOGRAPHY, SUPERCRITICAL FLUID; MASS SPECTROMETRY; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; STEREOISOMERISM;

EID: 79955122672     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.03.041     Document Type: Article

References (27)

1. Anderson A.C. Chem. Biol. 2003, 10:787.
2. Andrade C.H., Pasqualoto K.F.M., Ferreira E.I., Hopfinger A.J. Molecules 2010, 15:3281.
3. Dugo P., Cacciola F., Kumm T., Dugo G., Mondello L. J. Chromatogr. A 2008, 1184:353.
4. Stoll D.R., Li X., Wang X., Carr P.W., Porter S.E.G., Rutan S.C. J. Chromatogr. A 2007, 1168:3.
5. Guiochon G., Marchetti N., Mriziq K., Shalliker R.A. J. Chromatogr. A 2008, 1189:109.
6. Evans C.R., Jorgenson J.W. Anal. Bioanal. Chem. 2004, 378:1952.
7. Soukup R.J., Armstrong D.W. Multipledimensional Liquid Chromatography: Theory and Applications in Industrial Chemistry and Life Sciences 2008, 319. John Wiley & Sons, Inc., Hoboken, New Jersey. S.A. Cohen, M.R. Schure (Eds.).
8. Gomes R.F., Cassiano N.M., Pedrazzoli J., Cass Q.B. Chirality 2010, 22:35.
9. Hasegawa H., Fukushima T., Lee J.A., Tsukamoto K., Moriya K., Ono Y., Imai K. Anal. Bioanal. Chem. 2003, 377:886.
10. Cass Q.B., Degani A.L.G., Cassiano N.M., Pedrazolli J. J. Chromatogr. B 2001, 766:153.
11. Cass Q.B., Lima V.V., Oliveira R.V., Cassiano N.M., Degani A.L.G., Pedrazzoli J. J. Chromatogr. B 2003, 798:275.
12. Medvedovici A., Albu F., Georgita C., Sora D.I., Galaon T., Udrescu S., David V. J. Chromatogr. B 2007, 850:327.
13. Kammerer B., Kahlich R., Ufer M., Laufer S., Gleiter C.H. Anal. Biochem. 2005, 339:297.
14. Tian H., Xu J., Xu Y., Guan Y. J. Chromatogr. A 2006, 1137:42.
15. Davies I.L., Xu B., Markides K.E., Bartle K.D., Lee M.L. J. Microcolumn Sep. 1989, 1:71.
16. Payne K.M., Davies I.L., Bartle K.D., Markides K.E., Lee M.L. J. Chromatogr. A 1989, 477:161.
17. Juvancz Z., Payne K.M., Markides K.E., Lee M.L. Anal. Chem. 1990, 62:1384.
18. Hirata Y., Hashiguchi T., Kawata E. J. Sep. Sci. 2003, 26:531.
19. Sandra P., Medvedovici A., David F. LCGC Eur. 2003, 2.
20. Phinney K.W., Sander L.C., Wise S.A. Anal. Chem. 1998, 70:2331.
21. Alexander A.J., Staab A. Anal. Chem. 2006, 78:3835.
22. Welch C.J., Biba M., Gouker J.R., Kath G., Augustine P., Hosek P. Chirality 2007, 19:184.
23. Zeng L., Burton L., Yung K., Shushan B., Kassel D.B. J. Chromatogr. A 1998, 794:3.
24. Zeng L., Kassel D.B. Anal. Chem. 1998, 70:4380.
25. Kassel D.B. Chem. Rev. 2001, 101:255.
26. Zeng L., Xu R., Laskar D.B., Kassel D.B. J. Chromatogr. A 2007, 1169:193.
27. Laskar D.B., Zeng L., Xu R., Kassel D.B. Chirality 2008, 20:885.