Achiral-chiral LC/LC-FLD coupling for determination of carvedilol in plasma samples for bioequivalence purposes

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 327-335

  Medvedovici, Andrei ^a,b   Albu, Florin ^b   Georgita, Cristina ^b   Sora, Daniela Iuliana ^b   Galaon, Toma ^b   Udrescu, Stefan ^b   David, Victor ^a  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b LaborMed Pharma SA   (Romania)

Author keywords

Achiral and chiral RPLC separation mechanisms; Bidimensional LC; Bioequivalence study; Carvedilol; Cellulose tris(3,5 dimethyl phenylcarbamate); Enantiomers; Fluorescence detection; Pharmacokinetic parameters; Racemate; Simultaneous monitoring; Solid oral dosage forms

Indexed keywords

BIDIMENSIONAL LC; BIOEQUIVALENCE STUDY; CARVEDILOL; CELLULOSE TRIS(3,5-DIMETHYL-PHENYLCARBAMATE); CHIRAL RPLC SEPARATION MECHANISMS; FLUORESCENCE DETECTION; PHARMACOKINETIC PARAMETERS; RACEMATE; SIMULTANEOUS MONITORING; SOLID ORAL DOSAGE FORMS;

ELECTROMAGNETIC WAVE EMISSION; FLOATING BREAKWATERS; LIQUID CHROMATOGRAPHY; PATIENT MONITORING; PHARMACOKINETICS; PHASE SEPARATION; PLASMAS; WAVELENGTH;

DRUG PRODUCTS;

CARBAMIC ACID DERIVATIVE; CARVEDILOL; TRIS(3,5 DIMETHYL PHENYLCARBAMIC ACID; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENANTIOMER; FLUORESCENCE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; CALIBRATION; CARBAZOLES; CHROMATOGRAPHY, LIQUID; HUMANS; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; PROPANOLAMINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; THERAPEUTIC EQUIVALENCY;

EID: 34247265005     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.12.004     Document Type: Article

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