Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: Possible role of intestinal CYP3A and P-gp inhibition by curcumin

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 4, 2011, Pages 245-251

  Lee, Chong Ki ^a   Ki, Sung Hwan ^b   Choi, Jun Shik ^b  

^a Chodang University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

bioavailability; curcumin; CYP3A; etoposide; P gp; pharmacokinetics; rats

Indexed keywords

CURCUMIN; CYTOCHROME P450 3A; ETOPOSIDE; GLYCOPROTEIN P; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FIRST PASS EFFECT; HUMAN; HUMAN CELL; IC 50; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SMALL INTESTINE;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CURCUMIN; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ETOPOSIDE; FLUORESCENT DYES; INJECTIONS, INTRAVENOUS; INTESTINES; MALE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123;

EID: 79955070079     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.754     Document Type: Article

References (28)

1. Clark PI, Slevin ML,. The clinical pharmacology of etoposide and teniposide. Clin Pharmacokinet 1987; 12: 223-252. (Pubitemid 17072058)
2. Wozniak AJ, Ross WE,. DNA damage as a basis for 4′- demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-d-glucopyranoside) (etoposide) cytotoxicity. Cancer Res 1983; 43: 120-124. (Pubitemid 13172805)
3. Kawashiro T, Yamashita K, Zhao XJ, et al,. A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther 1998; 286: 1294-1300. (Pubitemid 29135542)
4. Piao YJ, Li X, Choi JS,. Effects of verapamil on etoposide pharmacokinetics after intravenous and oral administration in rats. Eur J Drug Metab Pharmacokinet 2008; 33: 159-164.
5. Li C, Li X, Choi JS,. Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats. Arch Pharm Res 2009; 32: 133-138.
6. Suh JH,. Effects of Cysteine on the Pharmacokinetics of Etoposide in Rats with Protein-Calorie Malnutrition. MS. Thesis, Seoul National University, Seoul, South Korea, 2010.
7. Leu BL, Huang JD,. Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother Pharmacol 1995; 35: 432-436.
8. Makhey VD, Guo A, Norris DA, Hu P, Yan J, Sinko PJ,. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharm Res 1998; 15: 1160-1167. (Pubitemid 28401704)
9. Carcel-Trullols J, Torres-Molina F, Araico A, Saadeddin A, Peris JE,. Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide. Cancer Chemother Pharmacol 2004; 54: 153-160. (Pubitemid 39044245)
10. Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA, Hiestand PC,. Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int J Cancer 1992; 51: 433-438.
11. Govindarajan VS,. Turmeric-chemistry, technology, and quality. Crit Rev Food Sci Nutr 1980; 12: 199-301.
12. Deshpande SS, Ingle AD, Maru GB,. Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis. Cancer Lett 1998; 123: 35-40. (Pubitemid 28046206)
13. Singletary K, MacDonald C, Iovinelli M, Fisher C, Wallig M,. Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. Carcinogenesis 1998; 19: 1039-1043. (Pubitemid 28375399)
14. Choi H, Chun YS, Kim SW, Kim MS, Park JW,. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol Pharmacol 2006; 70: 1664-1671.
15. Shukla PK, Khanna VK, Ali MM, Khan MY, Srimal RC,. Anti-ischemic effect of curcumin in rat brain. Neurochem Res 2008; 33: 1036-1043.
16. Srivastava KC, Bordia A, Verma SK,. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 1995; 52: 223-227.
17. Crespi CL, Miller VP, Penman BW,. Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Anal Biochem 1997; 248: 188-190. (Pubitemid 27218241)
18. Han CY, Cho KB, Choi HS, Han HK, Kang KW,. Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells. Carcinogenesis 2008; 29: 1837-1844.
19. Chung JW, Yang SH, Choi JS,. Effects of lovastatin on the pharmacokinetics of nicardipine in rats. Biopharm Drug Dispos 2010; 31: 436-441.
20. Li X, Yun JK, Choi JS,. Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos 2007; 28: 151-156. (Pubitemid 46730923)
21. Chiou WL,. Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm 1978; 6: 539-549.
22. Gibaldi M, Perrier D,. Pharmacokinetics, 2nd edn. Marcel-Dekker: New York, 1982.
23. Cummins CL, Jacobsen W, Benet LZ,. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002; 300: 1036-1045. (Pubitemid 34165010)
24. Lewis DFV,. 4. P450. Substrate specificity and metabolism. In Cytochromes P450. Structure, Function, and Mechanism. Taylor & Francis: Bristol, PA, 1996; 123.
25. Kimura Y, Ito H, Ohnishi R, Hatano T,. Inhibitory effects of polyphenols on human cytochrome P4503A4 and 2C9 activity. Food Chem Toxicol 2010; 48: 429-435.
26. Li X, Choi JS,. Effects of quercetin on the pharmacokinetics of etoposide after oral and intravenous administration of etoposide in rats. Anticancer Res 2009; 29: 1411-1416.
27. Piao Y, Shin SC, Choi JS,. Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats. Biopharm Drug Dispos 2008; 29: 245-249. (Pubitemid 351802847)
28. Li X, Choi JS,. Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats. Int J Pharm 2007; 337: 188-193. (Pubitemid 46756050)