메뉴 건너뛰기




Volumn 300, Issue 4, 2011, Pages

Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism

Author keywords

Dihydrotestosterone; Endothelium; Gene expression; Growth factor

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; BICALUTAMIDE; CYCLIN A; CYCLIN D1; DNA; ESTRADIOL; ROSCOVITINE; SEMAXANIB; SMALL INTERFERING RNA; TESTOSTERONE; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 79955066279     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01210.2010     Document Type: Article
Times cited : (75)

References (60)
  • 1
    • 39249083879 scopus 로고    scopus 로고
    • Potential target sites to modulate vascular endothelial dysfunction: Current perspectives and future directions
    • Balakumar P, Kaur T, Singh M. Potential target sites to modulate vascular endothelial dysfunction: current perspectives and future directions. Toxicology 245: 49-64, 2008.
    • (2008) Toxicology , vol.245 , pp. 49-64
    • Balakumar, P.1    Kaur, T.2    Singh, M.3
  • 3
    • 0034121281 scopus 로고    scopus 로고
    • Cell cycle molecular targets in novel anticancer drug discovery
    • Buolamwini JK. Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des 6: 379-392, 2000.
    • (2000) Curr Pharm Des , vol.6 , pp. 379-392
    • Buolamwini, J.K.1
  • 4
    • 0037301767 scopus 로고    scopus 로고
    • Cardiovascular effects of testosterone: Implications of the "male menopause"?
    • Channer KS, Jones TH. Cardiovascular effects of testosterone: implications of the "male menopause"? Heart 89: 121-122, 2003.
    • (2003) Heart , vol.89 , pp. 121-122
    • Channer, K.S.1    Jones, T.H.2
  • 5
    • 0344825994 scopus 로고    scopus 로고
    • Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease
    • Chung NA, Lydakis C, Belgore F, Li-Saw-Hee FL, Blann AD, Lip GY. Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease. Heart 89: 1411-1415, 2003.
    • (2003) Heart , vol.89 , pp. 1411-1415
    • Chung, N.A.1    Lydakis, C.2    Belgore, F.3    Li-Saw-Hee, F.L.4    Blann, A.D.5    Lip, G.Y.6
  • 6
    • 0021259280 scopus 로고
    • Minimal effect of estrogens on endothelial cell growth and production of prostacyclin
    • Corvazier E, Dupuy E, Dosne AM, Maclouf J. Minimal effect of estrogens on endothelial cell growth and production of prostacyclin. Thromb Res 34: 303-310, 1984.
    • (1984) Thromb Res , vol.34 , pp. 303-310
    • Corvazier, E.1    Dupuy, E.2    Dosne, A.M.3    Maclouf, J.4
  • 7
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study. Circulation 102: 1906-1911, 2000.
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 8
    • 0032890361 scopus 로고    scopus 로고
    • Structure, expression and receptor-binding properties of novel vascular endothelial growth factors
    • Eriksson U, Alitalo K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr Top Microbiol Immunol 237: 41-57, 1999.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 41-57
    • Eriksson, U.1    Alitalo, K.2
  • 9
    • 0043065525 scopus 로고    scopus 로고
    • Relation of thrombogenesis in systemic hypertension to angiogenesis and endothelial damage/dysfunction (a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial [ASCOT])
    • Felmeden DC, Spencer CG, Chung NA, Belgore FM, Blann AD, Beevers DG, Lip GY. Relation of thrombogenesis in systemic hypertension to angiogenesis and endothelial damage/dysfunction (a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial [ASCOT]). Am J Cardiol 92: 400-405, 2003.
    • (2003) Am J Cardiol , vol.92 , pp. 400-405
    • Felmeden, D.C.1    Spencer, C.G.2    Chung, N.A.3    Belgore, F.M.4    Blann, A.D.5    Beevers, D.G.6    Lip, G.Y.7
  • 10
    • 0035704913 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in angiogenesis
    • Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol 106: 148-156, 2001.
    • (2001) Acta Haematol , vol.106 , pp. 148-156
    • Ferrara, N.1    Gerber, H.P.2
  • 13
    • 60349129368 scopus 로고    scopus 로고
    • Human endothelial function and microvascular ageing
    • Gates PE, Strain WD, Shore AC. Human endothelial function and microvascular ageing. Exp Physiol 94: 311-316, 2009.
    • (2009) Exp Physiol , vol.94 , pp. 311-316
    • Gates, P.E.1    Strain, W.D.2    Shore, A.C.3
  • 14
    • 0034935259 scopus 로고    scopus 로고
    • Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft
    • Gregory CW, Johnson RT Jr, Presnell SC, Mohler JL, French FS. Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft. J Androl 22: 537-548, 2001.
    • (2001) J Androl , vol.22 , pp. 537-548
    • Gregory, C.W.1    Johnson, R.T.2    Presnell, S.C.3    Mohler, J.L.4    French, F.S.5
  • 15
    • 0037241928 scopus 로고    scopus 로고
    • Testosterone supplementation therapy for older men: Potential benefits and risks
    • Gruenewald DA, Matsumoto AM. Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc 51: 101-115, 2003.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 101-115
    • Gruenewald, D.A.1    Matsumoto, A.M.2
  • 17
    • 0027938209 scopus 로고
    • Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age
    • Hunter T, Pines J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79: 573-582, 1994.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 18
    • 0036532488 scopus 로고    scopus 로고
    • Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease
    • Kang SM, Jang Y, Kim JY, Chung N, Cho SY, Chae JS, Lee JH. Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol 89: 862-864, 2002.
    • (2002) Am J Cardiol , vol.89 , pp. 862-864
    • Kang, S.M.1    Jang, Y.2    Kim, J.Y.3    Chung, N.4    Cho, S.Y.5    Chae, J.S.6    Lee, J.H.7
  • 19
    • 37349118353 scopus 로고    scopus 로고
    • Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study
    • Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 116: 2694-2701, 2007.
    • (2007) Circulation , vol.116 , pp. 2694-2701
    • Khaw, K.T.1    Dowsett, M.2    Folkerd, E.3    Bingham, S.4    Wareham, N.5    Luben, R.6    Welch, A.7    Day, N.8
  • 20
    • 57149102903 scopus 로고    scopus 로고
    • Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer
    • Kintzel PE, Chase SL, Schultz LM, O'Rourke TJ. Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer. Pharmaco-therapy 28: 1511-1522, 2008.
    • (2008) Pharmaco-therapy , vol.28 , pp. 1511-1522
    • Kintzel, P.E.1    Chase, S.L.2    Schultz, L.M.3    O'Rourke, T.J.4
  • 22
    • 0141676097 scopus 로고    scopus 로고
    • Endocrine mechanisms of disease: Expression and degradation of androgen receptor: Mechanism and clinical implication
    • Lee DK, Chang C. Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication. J Clin Endocrinol Metab 88: 4043-4054, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4043-4054
    • Lee, D.K.1    Chang, C.2
  • 24
    • 33747117071 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the cardiovascular actions of oestrogens
    • Ling S, Komesaroff P, Sudhir K. Cellular mechanisms underlying the cardiovascular actions of oestrogens. Clin Sci (Lond) 111: 107-118, 2006.
    • (2006) Clin Sci (Lond) , vol.111 , pp. 107-118
    • Ling, S.1    Komesaroff, P.2    Sudhir, K.3
  • 26
    • 12544259451 scopus 로고    scopus 로고
    • Homologous up-regulation of androgen receptor expression by androgen in vascular smooth muscle cells
    • Ma R, Wu S, Lin Q. Homologous up-regulation of androgen receptor expression by androgen in vascular smooth muscle cells. Horm Res 63: 6-14, 2005.
    • (2005) Horm Res , vol.63 , pp. 6-14
    • Ma, R.1    Wu, S.2    Lin, Q.3
  • 27
    • 3242667701 scopus 로고    scopus 로고
    • The effect of testosterone replacement on endogenous inflammatory cy-tokines and lipid profiles in hypogonadal men
    • Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cy-tokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab 89: 3313-3318, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3313-3318
    • Malkin, C.J.1    Pugh, P.J.2    Jones, R.D.3    Kapoor, D.4    Channer, K.S.5    Jones, T.H.6
  • 28
    • 3242717140 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life
    • Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart 90: 871-876, 2004.
    • (2004) Heart , vol.90 , pp. 871-876
    • Malkin, C.J.1    Pugh, P.J.2    Morris, P.D.3    Kerry, K.E.4    Jones, R.D.5    Jones, T.H.6    Channer, K.S.7
  • 30
    • 0041767435 scopus 로고    scopus 로고
    • Endothelial cell functions
    • Michiels C. Endothelial cell functions. J Cell Physiol 196: 430-443, 2003.
    • (2003) J Cell Physiol , vol.196 , pp. 430-443
    • Michiels, C.1
  • 31
    • 0028200447 scopus 로고
    • Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions
    • Miller ME, Dores GM, Thorpe SL, Akerley WL. Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions. Thromb Res 74: 577-594, 1994.
    • (1994) Thromb Res , vol.74 , pp. 577-594
    • Miller, M.E.1    Dores, G.M.2    Thorpe, S.L.3    Akerley, W.L.4
  • 34
    • 0033304945 scopus 로고    scopus 로고
    • The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
    • Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ, Arnold A. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20: 501-534, 1999.
    • (1999) Endocr Rev , vol.20 , pp. 501-534
    • Pestell, R.G.1    Albanese, C.2    Reutens, A.T.3    Segall, J.E.4    Lee, R.J.5    Arnold, A.6
  • 35
    • 36849031372 scopus 로고    scopus 로고
    • 17Alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals
    • Qiao Y, Zhang ZK, Cai LQ, Tan C, Imperato-McGinley JL, Zhu YS. 17Alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals. Prostate 67: 1719-1728, 2007.
    • (2007) Prostate , vol.67 , pp. 1719-1728
    • Qiao, Y.1    Zhang, Z.K.2    Cai, L.Q.3    Tan, C.4    Imperato-Mcginley, J.L.5    Zhu, Y.S.6
  • 38
    • 0026006648 scopus 로고
    • Endothelium-derived vasoactive factors: I. Endothelium-dependent relaxation
    • Shepherd JT, Katusic ZS. Endothelium-derived vasoactive factors: I. Endothelium-dependent relaxation. Hypertension 18: III76-III85, 1991.
    • (1991) Hypertension , vol.18
    • Shepherd, J.T.1    Katusic, Z.S.2
  • 39
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 274: 1672-1677, 1996.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 40
    • 4644372261 scopus 로고    scopus 로고
    • Direct regulation of prostate blood flow by vascular endothelial growth factor and its participation in the androgenic regulation of prostate blood flow in vivo
    • Shibata Y, Kashiwagi B, Arai S, Fukabori Y, Suzuki K, Honma S, Yamanaka H. Direct regulation of prostate blood flow by vascular endothelial growth factor and its participation in the androgenic regulation of prostate blood flow in vivo. Endocrinology 145: 4507-4512, 2004.
    • (2004) Endocrinology , vol.145 , pp. 4507-4512
    • Shibata, Y.1    Kashiwagi, B.2    Arai, S.3    Fukabori, Y.4    Suzuki, K.5    Honma, S.6    Yamanaka, H.7
  • 43
    • 0842303571 scopus 로고    scopus 로고
    • Role of putative membrane receptors in the effect of androgens on human vascular cell growth
    • Somjen D, Kohen F, Gayer B, Kulik T, Knoll E, Stern N. Role of putative membrane receptors in the effect of androgens on human vascular cell growth. J Endocrinol 180: 97-106, 2004.
    • (2004) J Endocrinol , vol.180 , pp. 97-106
    • Somjen, D.1    Kohen, F.2    Gayer, B.3    Kulik, T.4    Knoll, E.5    Stern, N.6
  • 44
    • 0031903106 scopus 로고    scopus 로고
    • Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells
    • Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E, Stern N. Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32: 39-45, 1998.
    • (1998) Hypertension , vol.32 , pp. 39-45
    • Somjen, D.1    Kohen, F.2    Jaffe, A.3    Amir-Zaltsman, Y.4    Knoll, E.5    Stern, N.6
  • 45
    • 0031903106 scopus 로고    scopus 로고
    • Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells
    • Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E, Stern N. Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32: 39-45, 1998.
    • (1998) Hypertension , vol.32 , pp. 39-45
    • Somjen, D.1    Kohen, F.2    Jaffe, A.3    Amir-Zaltsman, Y.4    Knoll, E.5    Stern, N.6
  • 46
    • 0032500848 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is up-regulated in vitro and in vivo by androgens
    • Sordello S, Bertrand N, Plouet J. Vascular endothelial growth factor is up-regulated in vitro and in vivo by androgens. Biochem Biophys Res Commun 251: 287-290, 1998.
    • (1998) Biochem Biophys Res Commun , vol.251 , pp. 287-290
    • Sordello, S.1    Bertrand, N.2    Plouet, J.3
  • 48
    • 0015810958 scopus 로고
    • Findings leading to discontinuation of the 25-mg day estrogen group The coronary Drug Project Research Group
    • The Coronary Drug Project
    • The Coronary Drug Project. Findings leading to discontinuation of the 25-mg day estrogen group The coronary Drug Project Research Group. JAMA 226: 652-657, 1973.
    • (1973) JAMA , vol.226 , pp. 652-657
  • 49
    • 0014088849 scopus 로고
    • Treatment and survival of patients with cancer of the prostate
    • The Veterans Administration Co-operative Urological Research Group
    • The Veterans Administration Co-operative Urological Research Group. Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 124: 1011-1017, 1967.
    • (1967) Surg Gynecol Obstet , vol.124 , pp. 1011-1017
  • 50
    • 33751549522 scopus 로고    scopus 로고
    • Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men
    • Tivesten A, Hulthe J, Wallenfeldt K, Wikstrand J, Ohlsson C, Fager-berg B. Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men. J Clin Endo-crinol Metab 91: 4433-4437, 2006.
    • (2006) J Clin Endo-crinol Metab , vol.91 , pp. 4433-4437
    • Tivesten, A.1    Hulthe, J.2    Wallenfeldt, K.3    Wikstrand, J.4    Ohlsson, C.5    Fager-Berg, B.6
  • 51
    • 0242349760 scopus 로고    scopus 로고
    • Endothelial function testing as a biomarker of vascular disease
    • Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation 108: 2054-2059, 2003.
    • (2003) Circulation , vol.108 , pp. 2054-2059
    • Verma, S.1    Buchanan, M.R.2    Anderson, T.J.3
  • 55
    • 0037396460 scopus 로고    scopus 로고
    • Androgens and coronary artery disease
    • Wu FC, von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 24: 183-217, 2003.
    • (2003) Endocr Rev , vol.24 , pp. 183-217
    • Wu, F.C.1    von Eckardstein, A.2
  • 57
    • 33645954068 scopus 로고    scopus 로고
    • Molecular basis of steroid action in the prostate
    • Zhu YS. Molecular basis of steroid action in the prostate. Cellsci Rev 1: 27-55, 2005.
    • (2005) Cellsci Rev , vol.1 , pp. 27-55
    • Zhu, Y.S.1
  • 59
    • 0032579768 scopus 로고    scopus 로고
    • Differential regulation of AP-1 DNA binding activity in rat hypothalamus and pituitary by estrogen
    • Zhu YS, Pfaff DW. Differential regulation of AP-1 DNA binding activity in rat hypothalamus and pituitary by estrogen. Mol Brain Res 55: 115-125, 1998.
    • (1998) Mol Brain Res , vol.55 , pp. 115-125
    • Zhu, Y.S.1    Pfaff, D.W.2
  • 60
    • 33749042584 scopus 로고    scopus 로고
    • ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes
    • Zou JX, Zhong Z, Shi XB, Tepper CG, deVere White RW, Kung HJ, Chen H. ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. Prostate 66: 1474-1486, 2006.
    • (2006) Prostate , vol.66 , pp. 1474-1486
    • Zou, J.X.1    Zhong, Z.2    Shi, X.B.3    Tepper, C.G.4    de Vere White, R.W.5    Kung, H.J.6    Chen, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.