Delayed fracture healing in alcohol Abusers-A preliminary retrospective study

Open Bone Journal

Volumn 3, Issue , 2011, Pages 1-5

  Askew, Aaron ^a   Chakkalakal, Dennis ^a,b,c   Fang, Xiang ^d   McGuire, Michael ^a  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d CREIGHTON UNIVERSITY   (United States)

Author keywords

Alcohol abuse; Biological deficiency in fracture healing; Delayed union; Fracture healing time; Intertrochanteric femur fractures; Nonunion; Oral steroid use; Smoking; Subtrochanteric femur fractures; Tibia diaphyseal fractures

Indexed keywords

ALCOHOL;

ADULT; ADVERSE OUTCOME; AGED; ALCOHOL ABUSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FEMUR INTERTROCHANTERIC FRACTURE; FEMUR SUBTROCHANTERIC FRACTURE; FRACTURE NONUNION; HUMAN; MALE; NONHUMAN; ORTHOPEDIC SURGERY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; RETROSPECTIVE STUDY; SMOKING; TIBIA SHAFT FRACTURE;

EID: 79955065286     PISSN: None     EISSN: 18765254     Source Type: Journal    
DOI: 10.2174/1876525401103010001     Document Type: Article

References (22)

1. Chakkalakal DA. Alcohol-induced bone loss and deficient bone repair. Alcohol Clin Exp Res 2005; 29(12): 2077-90.
2. Seeman E. Effects of tobacco and alcohol use on bone. In: Osteoporosis (second edition) Vol.1, Marcus R, Feldman D, Kelsey J, editors. San Diego: Academic Press; 2001.
3. Turner RT. Skeletal response to alcohol. Alcohol Clin Exp Res 2000; 24(11): 1693-701.
4. Nyquist F, Berglund M, Nilsson BE, Obrant KJ. Nature and healing of tibial shaft fractures in alcohol abusers. Alcohol Alcohol 1997; 32(1): 91-5.
5. Tonnesen H, Pedersen A, Jensen MR, Moller A, Madsen JC. Ankle fractures and alcoholism. The influence of alcoholism on morbidity after malleolar fractures. J Bone Joint Surg Br 1991; 73(3): 511-3.
6. Kankare J, Hirvensalo E, Rokkanen P. Malleolar fractures in alcoholics treated with biodegradable internal fixation. 6/16 reoperations in a randomized study. Acta Orthop Scand 1995; 66(6): 524-8.
7. Adell R, Eriksson B, Nylen O, Ridell A. Delayed healing of fractures of the mandibular body. Int J Oral Maxillofac Surg 1987; 16(1): 15-24.
8. Law MD, Jr., Stein RE. Late infection in healed fractures after open reduction and internal fixation. Orthop Rev 1993; 22(5): 545-52.
9. Passeri LA, Ellis E, 3rd, Sinn DP. Relationship of substance abuse to complications with mandibular fractures. J Oral Maxillofac Surg 1993; 51(1): 22-5.
10. Bradley KA, Williams EC, Achtmeyer MN, Volpp B, Collins BJ, Kivlahan DR. Implementation of evidence-based alcohol screening in the Veterans Health Administration. Am J Manag Care 2006; 12(10): 597-606.
11. Sloan A, Hussain I, Maqsood M, Eremin O, El-Sheemy M. The effects of smoking on fracture healing. Surgeon 2010; 8(2): 111-6.
12. Nasell H, Adami J, Samnegard E, Tonnesen H, Ponzer S. Effect of smoking cessation intervention on results of acute fracture surgery: a randomized controlled trial. J Bone Joint Surg Am 2010; 92(6):1335-42.
13. Edwards P, Nilsson BE. Graphic representation of healing time in fracture of the shaft of the tibia. Acta Orthop Scand 1965; 36: 104-11.
14. Janicke-Lorenz J, Lorenz R. Alcoholism and fracture healing. A radiological study in the rat. Arch Orthop Trauma Surg 1984; 103(4): 286-9.
15. Nyquist F, Halvorsen V, Madsen JE, Nordsletten L, Obrant KJ. Ethanol and its effects on fracture healing and bone mass in male rats. Acta Orthop Scand 1999; 70(2): 212-16.
16. Chakkalakal DA, Novak JR, Fritz ED, et al. Chronic ethanol consumption results in deficient bone repair in rats. Alcohol Alcohol 2002; 37(1): 13-20.
17. Elmali N, Ertem K, Ozen S, et al. Fracture healing and bone mass in rats fed on liquid diet containing ethanol. Alcohol Clin Exp Res 2002; 26(4): 509-13.
18. Perrien DS, Brown EC, Fletcher TW, et al. Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis. J Pharmacol Exp Ther 2002; 303(3): 904-8.
19. Perrien DS, Wahl EC, Hogue WR, et al. IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats. Toxicol Sci 2004; 82(2): 656-60.
20. Brown EC, Perrien DS, Fletcher TW, et al. Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J Pharmacol Exp Ther 2002; 301(3): 1132-8.
21. Chakkalakal DA, Novak JR, Fritz ED, et al. Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption. Alcohol 2005; 36(3): 201-14.
22. Perrien DS, Liu Z, Wahl EC, et al. Chronic ethanol exposure is associated with a local increase in TNF-alpha and decreased proliferation in the rat distraction gap. Cytokine 2003; 23(6): 179-89.