The discovery of MMP7 inhibitors exploiting a novel selectivity trigger

ChemMedChem

Volumn 6, Issue 5, 2011, Pages 769-773

  Edman, Karl ^a   Furber, Mark ^b   Hemsley, Paul ^b   Johansson, Cristian ^a   Pairaudeau, Garry ^b   Petersen, Jens ^a   Stocks, Michael ^b   Tervo, Anu ^a   Ward, Alison ^b   Wells, Edward ^b   Wissler, Lisa ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Biological activity; Drug discovery; Inhibitors; Medicinal chemistry; X ray diffraction

Indexed keywords

COLLAGENASE 3; GELATINASE A; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; METALLOPROTEINASE INHIBITOR;

ARTICLE; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; MATRIX METALLOPROTEINASE 7; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; SEQUENCE ALIGNMENT;

EID: 79955044682     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000550     Document Type: Article

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