Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid

Journal of Ocular Pharmacology and Therapeutics

Volumn 27, Issue 2, 2011, Pages 115-121

  Khoobehi, Bahram ^a   Chiroli, Valerio ^b   Ronchetti, Daniela ^b   Miglietta, Daniela ^b   Thompson, Hillary ^a,c   Ongini, Ennio ^b   Impagnatiello, Francesco ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NicOx Research Institute   (Italy)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; METHOXAMINE; NCX 434; NITRIC OXIDE; NITRIC OXIDE DONOR; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INTRAOCULAR PRESSURE; MALE; NONHUMAN; OPTIC NERVE; OXYGEN SATURATION; TONOMETER; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA; DEXAMETHASONE; DIABETIC RETINOPATHY; INTRAOCULAR PRESSURE; INTRAVITREAL INJECTIONS; MACACA FASCICULARIS; MACULAR EDEMA; MALE; NITRATES; NITRIC OXIDE DONORS; OPTIC DISK; OXYGEN; RABBITS; TRIAMCINOLONE ACETONIDE;

EID: 79955042493     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2010.0150     Document Type: Article

References (30)

1. Augsten, R., Konigsdorffer, E., Schweitzer, D., and Strobel, J. Multisubstance analysis of reflection spectra before and after laser photocoagulation for proliferative diabetic retinopathy. Eur. J. Ophthalmol. 7:317-321, 1997. (Pubitemid 28042044)
2. Beach, J.M., Schwenzer, K.J., Srinivas, S., Kim, D., and Tie-deman, J.S. Oximetry of retinal vessels by dual-wavelength imaging: calibration and influence of pigmentation. J. Appl. Physiol. 86:748-758, 1999. (Pubitemid 29075834)
3. Sieker, H., and Hickam, J. Normal and impaired retinal vascular reactivity. Circulation 7:79-83, 1953.
4. Kohner, E.M., Patel, V., and Rassam, S.M. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 44:603-607, 1995.
5. Nyengaard, J.R, Ido, Y., Kilo, C., and Williamson, J.R In-teractions between hyperglycemia and hypoxia: implica-tions for diabetic retinopathy. Diabetes 53:2931-2938, 2004. (Pubitemid 39425919)
6. Nguyen, Q.D., Shah, S.M., Van Anden, E., Sung, J.U., Vitale, S., and Campochiaro, P.A. Supplemental oxygen improves diabetic macular edema: a pilot study. Invest. Ophthalmol. Vis. Sci. 45:617-624, 2004. (Pubitemid 38140522)
7. Diabetic Retinopathy Clinical Research Network; Elman, M.J., Aiello, L.P., Beck, R.W., Bressler, N.M., Bressler, S.B., Edwards, A.R, Ferris, F.L., Friedman, S.M., Glassman, A.R, Miller, K.M., Scott, I.U., Stockdale, C.R, and Sun, J.K. Ran-domized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for dia-betic macular edema. Ophthalmology 117:1064-1077, 2010.
8. Kiernan, D.F., and Mieler, W.F. The use of intraocular cor-ticosteroids. Expert Opin. Pharmacother. 10:2511-2525, 2009.
9. Holekamp, N.M., Thomas, M.A., and Pearson, A. The safety profile of long-term, high-dose intraocular corticosteroid delivery. Am. J. Ophthalmol. 139:421-428, 2005. (Pubitemid 40379067)
10. Goldstein, D.A., Godfrey, D.G, Hall, A., Callanan, D.G, Jaffe, GJ., Pearson, P.A., Usner, D.W., and Comstock, T.L. Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch. Ophthalmol. 125:1478-1485, 2007. (Pubitemid 350106679)
11. Kuo, C.H., McCluskey, P., and Gillies, M. Pharmacother-apeutic efficacy of preservative-free intravitreal triamcino-lone acetonide. Expert Opin. Pharmacother. 11:155-166, 2010.
12. Joos, K.M., Kay, M.D., Pillunat, L.E., Harris, A., Gendron, E.K., Feuer, W.J., and Steinwand, B.E. Effect of acute intra-ocular pressure changes on short posterior ciliary artery haemodynamics. Br. J. Ophthalmol. 83:33-38, 1999. (Pubitemid 29106327)
13. Khoobehi, B., Beach, J.M., and Kawano, H. Hyperspectral imaging for measurement of oxygen saturation in the optic nerve head. Invest. Ophthalmol. Vis. Sci. 45:1464-1472, 2004. (Pubitemid 38859326)
14. Nathanson, J.A., and McKee, M. Identification of an exten-sive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye. Invest. Ophthalmol. Vis. Sci. 36:1765-1773, 1995.
15. Moncada, S., Palmer, R.M., and Higgs, E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharma-col. Rev. 43:109-142, 1991.
16. Bryan, N.S., Bian, K., and Murad, F. Discovery of the nitric oxide signaling pathway and targets for drug development. Front. Biosci. 14:1-18, 2009.
17. Colasanti, M., and Suzuki, H. The dual personality of NO. Trends Pharmacol. Sci. 21:249-252, 2000. (Pubitemid 30445251)
18. Ronchetti, D., Impagnatiello, F., Guzzetta, M., Gasparini, L., Borgatti, M., Gambari, R., and Ongini, E. Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages. Eur. J. Pharmacol. 532:162-169, 2006.
19. Schmidtko, A., Tegeder, I., and Geisslinger G No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci. 32:337-346, 2009.
20. Simader, C., Lung, S., Weigert, G., Kolodjaschna, J., Fuchs-jäger-Mayrl, G., Schmetterer, L., and Polska, E. Role of NO in the control of choroidal blood flow during a decrease in ocular perfusion pressure. Invest. Ophthalmol. Vis. Sci. 50:372-377, 2009.
21. Galassi, F., Renieri, G., Sodi, A., et al. Nitric oxide proxies and ocular perfusion pressure in primary open angle glau-coma. Br. J. Ophthalmol. 88:757-760, 2004. (Pubitemid 38725583)
22. Nathanson, J.A. Nitrovasodilators as a new class of ocular hypotensive agents. J. Pharmacol. Exp. Ther. 260:956-965, 1992.
23. Borghi, V., Bastia, E., Guzzetta, M., et al. A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraoc-ular pressure in rabbit, dog, and primate models of glau-coma. J. Ocul. Pharmacol. Ther. 26:125-132, 2010.
24. Galassi, F., Masini, E., Giambene, B., Fabrizi, F., Uliva, C., Bolla, M., and Ongini, E. A topical nitric oxide-releasing dexamethasone derivative: effects on intraocular pressure and ocular haemodynamics in a rabbit glaucoma model. Br. J. Ophthalmol. 90:1414-1419, 2006. (Pubitemid 44702072)
25. Hammer, M., Thamm, E., and Schweitzer, D. A simple al-gorithm for in vivo ocular fundus oximetry compensating for non-haemoglobin absorption and scattering. Phys. Med. Biol. 47:N233-N238, 2002.
26. Narasimha-Iyer, H., Beach, J.M., Khoobehi, B., et al. Algo-rithms for automated oximetry along the retinal vascular tree from dual-wavelength fundus images. J. Biomed. Opt. 10:054013, 2005.
27. Bevan, J.A., and Joyce, E.H. Saline infusion into lumen of resistance artery and small vein causes contraction. Am. J. Physiol. 259:23-28, 1990.
28. Yang, X.L., Liu, K., and Xu, X. Update on treatments of diabetic macular edema. Chin. Med. J. (Engl). 122:2784-2790, 2009.
29. Schweitzer, D., Hammer, M., Kraft, J., et al. In vivo mea-surement of the oxygen saturation of retinal vessels in healthy volunteers. IEEE Trans. Biomed. Eng. 46:1454-1465, 1999.
30. Diestelhorst, M., Hinzpeter, B., and Krieglstein, GK. The effect of isosorbide-mononitrate eye drops on the human intraocular pressure and aqueous humor dynamics. Int. Ophthalmol. 15:259-262, 1991.