Analysis of aluminium content and iron homeostasis in nipple aspirate fluids from healthy women and breast cancer-affected patients

Journal of Applied Toxicology

Volumn 31, Issue 3, 2011, Pages 262-269

  Mannello, Ferdinando ^a   Tonti, Gaetana A ^a   Medda, Virginia ^a   Simone, Patrizia ^a   Darbre, Philippa D ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

Aluminium; Antiperspirant; Breast cancer; Cosmetics; Inflammation; Iron; Metalloestrogen; Nipple aspirate fluid

Indexed keywords

ALUMINUM; ANTIPERSPIRANT AGENT; FERRITIN; IRON; TRANSFERRIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BREAST CANCER; BREAST DUCT; BREAST MILK; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HIGH RISK PATIENT; HOMEOSTASIS; HUMAN; IMMUNOASSAY; MASS SPECTROMETRY; MICROENVIRONMENT; MILK; NIPPLE ASPIRATION; PRIORITY JOURNAL;

ADULT; AGED; ALUMINUM COMPOUNDS; BREAST NEOPLASMS; FEMALE; FERRITINS; HOMEOSTASIS; HUMANS; IRON COMPOUNDS; MIDDLE AGED; MILK, HUMAN; NIPPLES; PROTEIN BINDING; TRANSFERRIN;

EID: 79955039245     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1641     Document Type: Article

References (61)

1. Ahmad R, Naoui M, Neault JF, Diamantoglou S, Tajmir-Riahi HA. 1996. An FIRT spectroscopic study ofcalf thymus DNA complexation with Al(III) and Gal(III) cations. J. Biomol. Struct. Dyn. 13: 795-802.
2. Anghileri LJ, Plenat F, Labouyrie E, Thouvenot P. 2000. Iron- and aluminium-induced carcinogenesis. Anticancer Res. 20: 3007-3012.
3. Baker R, Rogers KD, Shepherd N, Stone N. 2010. New relationships between breast microcalcifications and cancer. Br. J. Cancer 103: 1034-1039.
4. Burkhart CG, Burkhart CN. 2008. Aluminium alters sweating by constricting the dermal duct lumen. Int. J. Dermatol. 47: 1306-1307.
5. Darbre PD. 2001. Underarm cosmetics are a cause of breast cancer. Eur. J. Cancer Prev. 10: 389-393.
6. Darbre PD. 2003. Underarm cosmetics and breast cancer. J. Appl. Toxicol. 23: 89-95.
7. Darbre PD. 2005a. Aluminium, antiperspirants and breast cancer. J. Inorg. Biochem. 99: 1912-1919.
8. Darbre PD. 2005b. Recorded quadrant incidence of female breast cancer in Great Britain suggests a disproportionate increase in the upper outer quadrant of the breast. Anticancer Res. 25: 2543-2550.
9. Darbre PD. 2006a. Environmental estrogens, cosmetics and breast cancer. Best Pract. Res. Clin. Endocrinol. Metab. 20: 121-143.
10. Darbre PD. 2006b. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J. Appl. Toxicol. 26: 191-197.
11. Darbre PD. 2009. Underarm antiperspirants/deodorants and breast cancer. Breast Cancer Res. 11(suppl. 3): S5.
12. Darbre PD, Charles AK. 2010. Environmental oestrogens and breast cancer: evidence for combined involvement of dietary, household and cosmetic xenoestrogens Anticancer Res. 30: 815-827.
13. Dua RS, Isacke CM, Gui JP. 2006. The intraductal approach to breast cancer biomarker discovery. J. Clin. Oncol. 24: 1209-1216.
14. Exley C. 1998. Does antiperspirant use increase the risk of aluminium related disease, including Alzheimer's disease? Mol. Med. Today 107-109.
15. Exley C (ed.). 2001. Aluminium and Alzheimer's disease. The Science that Describes the Link. London. Elsevier.
16. Exley C. 2004. The pro-oxidant activity of aluminium. Free Radic. Biol. Med.36: 380-387.
17. Exley C, Charles LM, Barr L, Martin C, Polwart A, Darbre PD. 2007. Aluminium in human breast tissue. J. Inorg. Biochem. 101: 1344-1346.
18. Fatemi SJA, Kadir FHA, Moore GR. 1991. Aluminium transport in blood serum. Biochem. J. 280: 527-532.
19. Fay MP, Feuer EJ. 1998. Confidence intervals for directly standardised rates: a method based on the gamma distribution. Stat. Med. 16: 791-801.
20. Fiszman GL, Middonno MC, de la Torre E, Farina M, Espanol AJ, Sales ME. 2007. Activation of muscarinic cholinergic receptors induces MCF-7 cells proliferation and angiogenesis by stimulating nitric oxide synthase activity. Cancer Biol. Ther. 6: 1106-1113.
21. Flarend R, Bin T, Elmore D, Hem SL. 2001. A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem. Toxicol. 39: 163-168.
22. Kaizer RR, Correa MC, Gris LR, da Rosa CS, Bohrer D, Morsch VM, Schetinger MR. 2008. Effect of long-term exposure to aluminium on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochem. Res. 33: 2294-2301.
23. Karlik SJ, Eichhorn GL, Lewis PN, Crapper DR. 1980. Interaction of aluminium species with deoxyribonucleic acid. Biochemistry 19: 5991-5998.
24. Kim Y, Olivi L, Cheong JH, Maertens A, Bressler JP. 2007. Aluminium stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Toxicol. Appl. Pharmacol. 220: 349-356.
25. King BL, Love SM. 2006. The intraductal approach to breast cancer: raison d'etre. Breast Cancer Res. 8:206.
26. Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz MA, Rondeau V. 2007. Human health risk assessment for aluminium, Aluminium oxide, and aluminium hydroxide. J. Toxicol. Environ. Health B Crit. Rev. 10: 1-269.
27. Laden K, Felger CB. 1988. Antiperspirants and Deodorants. Cosmetic Science and Technology Series, Vol. 7. Marcel Dekker: New York.
28. Latha KS, Anitha S, Rao KS, Viswamitra MA. 2002. Molecular understanding of aluminium induced topological changes in (CCG) 12 triplet repeats: relevance to neurological disorders. Biochem. Biophys. Acta 1588: 56-64.
29. Lee MM, Petrakis NL, Wrensch MR, King EB, Miike R, Sickles E. 1994. Association of abnormal nipple aspirate cytology and mammographic pattern and density. Cancer Epidemiol. Biomark. Prev. 3: 33-36.
30. Li J, Zhao J, Yu X, Lange J, Kuerer H, Krishnamurthy S, Schilling E, Khan SA, Sukumar S, Chan DW. 2005. Identification of biomarkers for breast cancer in nipple aspirations and ductal lavage fluid. Clin. Cancer Res. 11: 8312-8320.
31. Lipworth L. 1995. Epidemiology of breast cancer. Eur. J. Cancer Prevent. 4: 7-30.
32. Lukiw WJ, LeBlanc HJ, Carver LA, McLachlan DR, Bazan NG. 1998. Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminium and implications for neurodegenerative disease. J. Mol. Neurosci. 11: 67-78.
33. Malatesta M, Mannello F, Bianchi G, Sebastiani M, Gazzanelli G. 2000. Biochemical and ultrastructural features of human milk and nipple aspirate fluids. J. Clin. Lab. Anal. 14: 330-335.
34. Mannello F. 2008. Analysis of the intraductal microenvironment for the early diagnosis of breast cancer: dentification of biomarkers in nipple-aspirate fluids. Expert. Opin. Med. Diagn. 2: 1221-1231.
35. Mannello F, Sebastiani M. 2003. Zymographic analyses and measurement of matrix metalloproteinase-2 and -9 in nipple aspirate fluids. Clin. Chem. 49: 1546-1550.
36. Mannello F, Malatesta M, Sebastiani M, Battistelli S. 1999. Molecular forms and ultrastructural localization of prostate-specific antigen in nipple aspirate fluid. Clin. Chem. 49: 2263-2266.
37. Mannello F, Tonti GA, Papa S. 2006. Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies. Breast Cancer Res. Treat. 97: 115-130.
38. Mannello F, Tonti GA, Qin W, Zhu W, Sauter ER. 2007. Do nipple aspirate fluid epithelial cells and their morphology predict breast cancer development? Breast Cancer Res. Treat. 102: 125-127.
39. Mannello F, Fabbri L, Ciandrini E, Tonti GA. 2008a. Increased levels of erythropoietin in nipple aspirate fluid and in ductal cells from breast cancer patients. Cell. Oncol. 30: 51-61.
40. Mannello F, Tonti GA, Canestrari F. 2008b. Nutrients and nipple aspirate fluid composition: the breast microenvironment regulates protein expression and cancer aetiology. Genes Nutr. 3: 77-85.
41. Mannello F, Medda V, Smaniotto A, Tonti GA. 2009a. Intracrinology of breast microenvironment: hormonal status in nipple aspirate fluid and its relationship to breast cancer. Expert Rev. Endocrinol. Metab. 4: 493-506.
42. Mannello F, Tonti GA, Darbre PD. 2009b. Concentration of aluminium in breast cyst fluids collected from women affected by gross cystic breast disease. J. Appl. Toxicol. 29: 1-6.
43. McGrath KG. 2003. An earlier age of breast cancer diagnosis related to more frequent use of antiperspirants/deodorants and underarm shaving. Eur. J. Cancer Prev. 12: 479-485.
44. McGrath KG. 2009. Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century. Med. Hypotheses 72: 665-674.
45. Miller WR. 1996. Estrogen and Breast Cancer. Chapman and Hall: London.
46. Mulay IL, Roy R, Knox BE, Suhr NH, Delaney WE. 1971. Trace-metal analysis of cancerous and noncancerous human tissues. J. Natl Cancer Inst. 47: 1-13.
47. Ng KH, Bradley DA, Looi LM. 1997. Elevated trace element concentrations in malignant breast tissues. Br. J. Radiol. 70: 375-382.
48. Petrakis NL. 1986. Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid. Breast Cancer Res. Treat. 8:7-19.
49. Petrakis NL. 1993. Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid. Cancer Epidemiol. Biomarkers Prev. 2:3-10.
50. Qin W, Zhu W, Wagner-Mann C, Sauter ER. 2003. Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease. Ann. Surg. Oncol. 10: 948-953.
51. Rangaswami H, Bulbule A, Kundu GC. 2006. Osteopontin: role in cell signalling and cancer progression. Trends Cell Biol. 16: 79-87.
52. Rowatt E, Sorensen ES, Triffit J, Viess A, Williams RJP. 1997. An examination of the binding of aluminium to protein and mineral components of bone and teeth. J. Inorg. Biochem. 68: 235-238.
53. Sauter ER. 2005. Analysis of nipple aspirate fluid for diagnosis of breast cancer: an alternative to invasive biopsy. Expert Rev. Mol. Diagn. 5: 873-881.
54. Shiek S, Ahmed SJ, Santosh W. 2010. Metallomic profiling and linkage map analysis of early Parkinson's disease: a new insight to aluminium marker for the possible diagnosis. PLoS ONE 5(6): 1-9.
55. Shpyleva SI, Tryndyak VP, Kovalchuk O, Starlard-Davenport A, Chekhun VF, Beland FA, Pogribny IP. 2010. Role of ferritin alterations in human breast cancer cells. Breast Cancer Res. Treat. (in press); doi: 10.1007/s10549-010-0849-4.
56. Silva VS, Nunes MA, Cordeiro JM, Calejo AI, Santos S, Neves P, Sykes A, Morgado F, Dunant Y, Goncalves PP. 2007. Comparative effects of aluminium and ouabain on synaptosomal choline uptake, acetylcholine release and (Na+/K+)ATPase. Toxicology 236: 158-177.
57. Singletary SE, Connolly JL. 2006. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J. Clin. 56: 37-47.
58. Yokel RA, McNamara PJ. 2001. Aluminium toxicokinetics: an updated minireview. Pharmacol. Toxicol. 88: 159-167.
59. Zatta P, Drago D, Bolognin S, Sensi SL. 2009. Alzheimer's disease, metal ions and metal homeostatic therapy. Trends Pharmacol. Sci. 30: 346-354.
60. Zhang L, Li X, Gu Q, Zhu Y, Zhao H, Li Y, Zhang Z. 2010. Effects of subchronic aluminium exposure on serum concentrations of miron and iron-associated proteins in rats. Biol. Trace Elem. Res. [EPub ahead of print 19 June].
61. Zhang RY, Liu Y, Pang DW, Cai RX, Qi YP. 2002. Spectroscopic and voltammetric study on the binding of aluminium (III) to DNA. Anal. Sci. 18: 761-766.