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Volumn 4, Issue 5, 2009, Pages 493-505

Intracrinology of breast microenvironment: Hormonal status in nipple aspirate fluid and its relationship to breast cancer

Author keywords

Breast cancer; Diagnosis; Hormones; Intracrinology; Nipple aspirate fluid; Prognosis; Tumor marker

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; CALCITONIN; CATHEPSIN D; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGEN; ESTROGEN SULFOTRANSFERASE; ESTRONE; ESTRONE SULFATE; INTERLEUKIN 6; LEPTIN; ORAL CONTRACEPTIVE AGENT; PRASTERONE; PROGESTERONE; PROLACTIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN PS2; SEX HORMONE BINDING GLOBULIN; STEROID HORMONE; STERYL SULFATASE; TESTOSTERONE; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR MARKER;

EID: 70450054558     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/eem.09.28     Document Type: Review
Times cited : (10)

References (79)
  • 2
    • 21344435549 scopus 로고    scopus 로고
    • Breast-tissue sampling for risk assessment and prevention
    • Brilliant overview clarifying the advantages and drawbacks of breast cell- and tissue-collection methods; useful for improvement of diagnostic accuracy and risk assesment of breast cancer
    • Fabian CJ, Kimler BF, Mayo MS, Khan SA. Breast-tissue sampling for risk assessment and prevention. Endocr. Relat. Cancer 12(2), 185-213 (2005). •• Brilliant overview clarifying the advantages and drawbacks of breast cell- and tissue-collection methods; useful for improvement of diagnostic accuracy and risk assesment of breast cancer.
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.2 , pp. 185-213
    • Fabian, C.J.1    Kimler, B.F.2    Mayo, M.S.3    Khan, S.A.4
  • 3
    • 38349159248 scopus 로고    scopus 로고
    • Clinical cancer advances 2007: Major research advances in cancer treatment, prevention, and screening - A report from the American Society of Clinical Oncology
    • Gralow J, Ozols RF, Bajorin DF et al. Clinical cancer advances 2007: major research advances in cancer treatment, prevention, and screening - a report from the American Society of Clinical Oncology. J. Clin. Oncol. 26(2), 313-325 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.2 , pp. 313-325
    • Gralow, J.1    Ozols, R.F.2    Bajorin, D.F.3
  • 4
    • 27944487550 scopus 로고    scopus 로고
    • Analysis of nipple aspirate fluid for diagnosis of breast cancer: An alternative to invasive biopsy
    • Well described review of potential utility of nipple aspirate fluid (NAF) as a new tool for early detection of breast cancer
    • Sauter ER. Analysis of nipple aspirate fluid for diagnosis of breast cancer: an alternative to invasive biopsy. Expert Rev. Mol. Diagn. 5(6), 873-881 (2005). • Well described review of potential utility of nipple aspirate fluid (NAF) as a new tool for early detection of breast cancer.
    • (2005) Expert Rev. Mol. Diagn. , vol.5 , Issue.6 , pp. 873-881
    • Sauter, E.R.1
  • 5
    • 49749140722 scopus 로고    scopus 로고
    • Nutrients and nipple aspirate fluid composition: The breast microenvironment regulates protein expression and cancer aetiology
    • Updated review of the effects of diet in NAF microenvironment biomolecular composition
    • Mannello F, Tonti GA, Canestrari F. Nutrients and nipple aspirate fluid composition: the breast microenvironment regulates protein expression and cancer aetiology. Genes Nutr. 3, 77-85 (2008). • Updated review of the effects of diet in NAF microenvironment biomolecular composition.
    • (2008) Genes Nutr. , vol.3 , pp. 77-85
    • Mannello, F.1    Tonti, G.A.2    Canestrari, F.3
  • 7
    • 0002438326 scopus 로고
    • Chronic mastitis
    • Keynes G. Chronic mastitis. Br. J. Surgery 11, 89-121 (1923).
    • (1923) Br. J. Surgery , vol.11 , pp. 89-121
    • Keynes, G.1
  • 8
    • 0023038179 scopus 로고
    • Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid
    • First review on the epidemiology and biocomposition of NAF
    • Petrakis NL. Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid. Breast Cancer Res. Treat. 8(1), 7-19 (1986). • First review on the epidemiology and biocomposition of NAF.
    • (1986) Breast Cancer Res. Treat. , vol.8 , Issue.1 , pp. 7-19
    • Petrakis, N.L.1
  • 9
    • 0027356167 scopus 로고
    • Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid
    • Petrakis NL. Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid. Cancer Epidemiol. Biomarkers Prev. 2(1), 3-10 (1993).
    • (1993) Cancer Epidemiol. Biomarkers Prev. , vol.2 , Issue.1 , pp. 3-10
    • Petrakis, N.L.1
  • 10
    • 33644980249 scopus 로고    scopus 로고
    • The intraductal approach to breast cancer biomarker discovery
    • Comprehensive review highlighting the potential applications of NAF studies
    • Dua RS, Isacke CM, Gui GP. The intraductal approach to breast cancer biomarker discovery. J. Clin. Oncol. 24(7), 1209-1216 (2006). • Comprehensive review highlighting the potential applications of NAF studies.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.7 , pp. 1209-1216
    • Dua, R.S.1    Isacke, C.M.2    Gui, G.P.3
  • 11
    • 0343548892 scopus 로고
    • Breast stasis as the cause of mammary cancer
    • Milestone hypothesis about the NAF formation mechanisms and its relationship to cancer
    • Adair FE , Bagg HJ. Breast stasis as the cause of mammary cancer. Int. Clin. 4, 19-26 (1925). •• Milestone hypothesis about the NAF formation mechanisms and its relationship to cancer.
    • (1925) Int. Clin. , vol.4 , pp. 19-26
    • Adair, F.E.1    Bagg, H.J.2
  • 12
    • 0038849778 scopus 로고
    • Breast fluid cells help in early cancer detection
    • Sartorius OW. Breast fluid cells help in early cancer detection. JAMA 224, 823-827 (1973).
    • (1973) JAMA , vol.224 , pp. 823-827
    • Sartorius, O.W.1
  • 13
    • 0016732134 scopus 로고
    • Association of race, age, menopausal status, and cerumen type with breast fluid secretion in nonlactating women, as determined by nipple aspiration
    • Petrakis NL, Mason L, Lee R, Sugimoto B, Pawson S, Catchpool F. Association of race, age, menopausal status, and cerumen type with breast fluid secretion in nonlactating women, as determined by nipple aspiration. J. Natl Cancer Inst. 54(4), 829-834 (1975).
    • (1975) J. Natl Cancer Inst. , vol.54 , Issue.4 , pp. 829-834
    • Petrakis, N.L.1    Mason, L.2    Lee, R.3    Sugimoto, B.4    Pawson, S.5    Catchpool, F.6
  • 14
    • 0029054978 scopus 로고
    • The biochemistry of breast cyst fluids and duct secretions
    • Sartorius OW. The biochemistry of breast cyst fluids and duct secretions. Breast Cancer Res. Treat. 35(3), 255-266 (1995).
    • (1995) Breast Cancer Res. Treat. , vol.35 , Issue.3 , pp. 255-266
    • Sartorius, O.W.1
  • 15
    • 0033450730 scopus 로고    scopus 로고
    • Biological markers of risk in nipple aspirate fluid are associated with residual cancer and tumour size
    • Sauter ER, Ehya H, Babb J et al. Biological markers of risk in nipple aspirate fluid are associated with residual cancer and tumour size. Br. J. Cancer 81(7), 1222-1227 (1999).
    • (1999) Br. J. Cancer , vol.81 , Issue.7 , pp. 1222-1227
    • Sauter, E.R.1    Ehya, H.2    Babb, J.3
  • 16
    • 60549087395 scopus 로고    scopus 로고
    • Analysis of the intraductal microenvironment for the early diagnosis of breast cancer: Identification of biomarkers in nipple-aspirate fluids
    • Overview of morphologic and biomolecular studies performed on NAF
    • Mannello F. Analysis of the intraductal microenvironment for the early diagnosis of breast cancer: identification of biomarkers in nipple-aspirate fluids. Expert Opin. Med. Diagn. 2(11), 1221-1231 (2008). • Overview of morphologic and biomolecular studies performed on NAF.
    • (2008) Expert Opin. Med. Diagn. , vol.2 , Issue.11 , pp. 1221-1231
    • Mannello, F.1
  • 17
    • 33646587002 scopus 로고    scopus 로고
    • Human gross cyst breast disease and cystic fluid: Bio-molecular, morphological, and clinical studies
    • Detailed state-of-the-art of 30 years of morphological, biochemical, hormonal and clinical findings on breast cyst fluid collected from gross cystic breast disease-affected women
    • Mannello F, Tonti GA, Papa S. Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies. Breast Cancer Res. Treat. 97(2), 115-129 (2006). •• Detailed state-of-the-art of 30 years of morphological, biochemical, hormonal and clinical findings on breast cyst fluid collected from gross cystic breast disease-affected women.
    • (2006) Breast Cancer Res. Treat. , vol.97 , Issue.2 , pp. 115-129
    • Mannello, F.1    Tonti, G.A.2    Papa, S.3
  • 20
    • 33748743717 scopus 로고    scopus 로고
    • Nipple aspirate fluid color is associated with breast cancer
    • DOI 10.1016/j.cdp.2006.07.006, PII S0361090X06001115
    • Sauter ER, Winn JN, Dale PS, Wagner-Mann C. Nipple aspirate fluid color is associated with breast cancer. Cancer Detect. Prev. 30(4), 322-328 (2006). (Pubitemid 44402904)
    • (2006) Cancer Detection and Prevention , vol.30 , Issue.4 , pp. 322-328
    • Sauter, E.R.1    Winn, J.N.2    Dale, P.S.3    Wagner-Mann, C.4
  • 21
    • 33646824575 scopus 로고    scopus 로고
    • Intra- And inter-individual variability in measurements of biomarkers for oxidative damage in vivo: Nutrition and Breast Health Study
    • DOI 10.1080/13547500600565693, PII Q74262848910
    • Kato I, Ren J, Heilbrun LK, Djuric Z. Intra- and inter-individual variability in measurements of biomarkers for oxidative damage in vivo: NUTRITION and Breast Health Study. Biomarkers 11(2), 143-152 (2006). (Pubitemid 43772011)
    • (2006) Biomarkers , vol.11 , Issue.2 , pp. 143-152
    • Kato, I.1    Ren, J.2    Heilbrun, L.K.3    Djuric, Z.4
  • 23
    • 34848917278 scopus 로고    scopus 로고
    • Oxytocin: Bringing magic into nipple aspiration
    • Suijkerbuijk KP, van der WE, van Diest PJ. Oxytocin: bringing magic into nipple aspiration. Ann. Oncol. 18(10), 1743-1744 (2007).
    • (2007) Ann. Oncol. , vol.18 , Issue.10 , pp. 1743-1744
    • Suijkerbuijk, K.P.1    Van Der, W.E.2    Van Diest, P.J.3
  • 24
  • 25
    • 60549106219 scopus 로고    scopus 로고
    • Protein profile analysis of the breast microenvironment to differentiate healthy women from breast cancer patients
    • Updated review of NAF protein composition
    • Mannello F, Medda V, Tonti GA. Protein profile analysis of the breast microenvironment to differentiate healthy women from breast cancer patients. Expert Rev. Proteomics 6(1), 43-60 (2009). •• Updated review of NAF protein composition.
    • (2009) Expert Rev. Proteomics , vol.6 , Issue.1 , pp. 43-60
    • Mannello, F.1    Medda, V.2    Tonti, G.A.3
  • 26
    • 33847663891 scopus 로고    scopus 로고
    • Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings
    • DOI 10.1016/j.cdp.2006.12.004, PII S0361090X06002315
    • Sauter ER, Wagner-Mann C, Ehya H, Klein-Szanto A. Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Detect. Prev. 31(1), 50-58 (2007). (Pubitemid 46367450)
    • (2007) Cancer Detection and Prevention , vol.31 , Issue.1 , pp. 50-58
    • Sauter, E.R.1    Wagner-Mann, C.2    Ehya, H.3    Klein-Szanto, A.4
  • 27
    • 33746788624 scopus 로고    scopus 로고
    • New development in intracrinology of breast carcinoma
    • Sasano H, Suzuki T, Nakata T, Moriya T. New development in intracrinology of breast carcinoma. Breast Cancer 13(2), 129-136 (2006).
    • (2006) Breast Cancer , vol.13 , Issue.2 , pp. 129-136
    • Sasano, H.1    Suzuki, T.2    Nakata, T.3    Moriya, T.4
  • 29
    • 0031775704 scopus 로고    scopus 로고
    • From endocrinology to intracrinology
    • Sasano H, Suzuki T, Harada N. From endocrinology to intracrinology. Endocr. Pathol. 9(1), 9-20 (1998).
    • (1998) Endocr. Pathol. , vol.9 , Issue.1 , pp. 9-20
    • Sasano, H.1    Suzuki, T.2    Harada, N.3
  • 31
    • 0026694397 scopus 로고
    • The prevention of breast cancer through reduced ovarian steroid exposure
    • Spicer DV, Pike MC. The prevention of breast cancer through reduced ovarian steroid exposure. Acta Oncol. 31(2), 167-174 (1992).
    • (1992) Acta Oncol. , vol.31 , Issue.2 , pp. 167-174
    • Spicer, D.V.1    Pike, M.C.2
  • 32
    • 0027304028 scopus 로고
    • Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk
    • Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol. Rev. 15(1), 17-35 (1993). (Pubitemid 23269068)
    • (1993) Epidemiologic Reviews , vol.15 , Issue.1 , pp. 17-35
    • Pike, M.C.1    Spicer, D.V.2    Dahmoush, L.3    Press, M.F.4
  • 33
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351(9113), 1393-1396 (1998).
    • (1998) Lancet , vol.351 , Issue.9113 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 34
    • 0028942126 scopus 로고
    • A prospective study of endogenous estrogens and breast cancer in postmenopausal women
    • Toniolo PG, Levitz M, Zeleniuch-Jacquotte A et al. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J. Natl Cancer Inst. 87(3), 190-197 (1995).
    • (1995) J. Natl Cancer Inst. , vol.87 , Issue.3 , pp. 190-197
    • Toniolo, P.G.1    Levitz, M.2    Zeleniuch-Jacquotte, A.3
  • 36
    • 59149105699 scopus 로고    scopus 로고
    • Intratumoral estrogen production in breast carcinoma: Significance of aromatase
    • Suzuki T, Miki Y, Ohuchi N, Sasano H. Intratumoral estrogen production in breast carcinoma: significance of aromatase. Breast Cancer 15(4), 270-277 (2008).
    • (2008) Breast Cancer , vol.15 , Issue.4 , pp. 270-277
    • Suzuki, T.1    Miki, Y.2    Ohuchi, N.3    Sasano, H.4
  • 37
    • 0141884356 scopus 로고    scopus 로고
    • Formation of estrone and estradiol from estrone sulfate by normal breast parenchymal tissue
    • Chatterton RT Jr, Geiger AS, Gann PH, Khan SA. Formation of estrone and estradiol from estrone sulfate by normal breast parenchymal tissue. J. Steroid Biochem. Mol. Biol. 86(2), 159-166 (2003).
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.86 , Issue.2 , pp. 159-166
    • Chatterton Jr., R.T.1    Geiger, A.S.2    Gann, P.H.3    Khan, S.A.4
  • 38
    • 0017695785 scopus 로고
    • Prolactin, oestrogen, and lipids in breast fluid
    • Wynder EL, Hill P. Prolactin, oestrogen, and lipids in breast fluid. Lancet 2(8043), 840-842 (1977). •• Initial evidence of the hormone content in NAF. (Pubitemid 8199527)
    • (1977) Lancet , vol.2 , Issue.8043 , pp. 840-842
    • Wynder, E.L.1    Hill, P.2
  • 40
    • 0019405430 scopus 로고
    • Breast secretion in Finnish women: A metabolic epidemiologic study
    • DOI 10.1002/1097-0142(19810315)47:6<1444::AID-CNCR2820470634>3.0. CO;2-A
    • Wynder EL, Hill P, Laakso K, Littner R, Kettunen K. Breast secretion in Finnish women: a metabolic epidemiologic study. Cancer 47(6), 1444-1450 (1981). (Pubitemid 11090516)
    • (1981) Cancer , vol.47 , Issue.6 , pp. 1444-1450
    • Wynder, E.L.1    Hill, P.2    Laakso, K.3
  • 41
    • 55449113706 scopus 로고    scopus 로고
    • Increased shedding of soluble fragments of p-cadherin in nipple aspirate fluids from women with breast cancer
    • Mannello F, Tonti GA, Medda V, Pederzoli A, Sauter ER. Increased shedding of soluble fragments of p-cadherin in nipple aspirate fluids from women with breast cancer. Cancer Sci. 99(11), 2160-2169 (2008).
    • (2008) Cancer Sci. , vol.99 , Issue.11 , pp. 2160-2169
    • Mannello, F.1    Tonti, G.A.2    Medda, V.3    Pederzoli, A.4    Sauter, E.R.5
  • 42
    • 33847174965 scopus 로고    scopus 로고
    • Do nipple aspirate fluid epithelial cells and their morphology predict breast cancer development? [2]
    • DOI 10.1007/s10549-006-9313-x
    • Mannello F, Tonti GA, Qin W, Zhu W, Sauter ER. Do nipple aspirate fluid epithelial cells and their morphology predict breast cancer development? Breast Cancer Res. Treat. 102(1), 125-127 (2007). • Working hypothesis on the role of adhesion molecules in the cellular mechanisms of NAF formation. (Pubitemid 46294963)
    • (2007) Breast Cancer Research and Treatment , vol.102 , Issue.1 , pp. 125-127
    • Mannello, F.1    Tonti, G.A.M.2    Qin, W.3    Zhu, W.4    Sauter, E.R.5
  • 43
    • 0023490467 scopus 로고
    • Influence of pregnancy and lactation on serum and breast fluid estrogen levels: Implications for breast cancer risk
    • Petrakis NL, Wrensch MR, Ernster VL et al. Influence of pregnancy and lactation on serum and breast fluid estrogen levels: implications for breast cancer risk. Int. J. Cancer 40(5), 587-591 (1987).
    • (1987) Int. J. Cancer , vol.40 , Issue.5 , pp. 587-591
    • Petrakis, N.L.1    Wrensch, M.R.2    Ernster, V.L.3
  • 44
    • 0023617913 scopus 로고
    • Benign and malignant breast disease: Initial study results of serum and breast fluid analyses of endogenous estrogens
    • Ernster VL, Wrensch MR, Petrakis NL et al. Benign and malignant breast disease: initial study results of serum and breast fluid analyses of endogenous estrogens. J. Natl Cancer Inst. 79(5), 949-960 (1987).
    • (1987) J. Natl Cancer Inst. , vol.79 , Issue.5 , pp. 949-960
    • Ernster, V.L.1    Wrensch, M.R.2    Petrakis, N.L.3
  • 45
    • 0021073518 scopus 로고
    • Nipple aspirate cytology for the study of breast cancer precursors
    • King EB, Chew KL, Petrakis NL, Ernster VL. Nipple aspirate cytology for the study of breast cancer precursors. J. Natl Cancer Inst. 71(6), 1115-1121 (1983).
    • (1983) J. Natl Cancer Inst. , vol.71 , Issue.6 , pp. 1115-1121
    • King, E.B.1    Chew, K.L.2    Petrakis, N.L.3    Ernster, V.L.4
  • 46
    • 13944272628 scopus 로고    scopus 로고
    • Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening population
    • DOI 10.1158/1055-9965.EPI-04-0289
    • Tice JA, Miike R, Adduci K, Petrakis NL, King E, Wrensch MR. Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening population. Cancer Epidemiol. Biomarkers Prev. 14(2), 324-328 (2005). (Pubitemid 40270092)
    • (2005) Cancer Epidemiology Biomarkers and Prevention , vol.14 , Issue.2 , pp. 324-328
    • Tice, J.A.1    Miike, R.2    Adduci, K.3    Petrakis, N.L.4    King, E.5    Wrensch, M.R.6
  • 48
    • 0023019954 scopus 로고
    • Hormones in breast fluid
    • Rose DP. Hormones in breast fluid. Breast Cancer Res. Treat. 8(1), 25-28 (1986).
    • (1986) Breast Cancer Res. Treat. , vol.8 , Issue.1 , pp. 25-28
    • Rose, D.P.1
  • 49
    • 0020695601 scopus 로고
    • Testosterone in breast fluid
    • Hill P, Garbaczewski L, Wynder EL. Testosterone in breast fluid. Lancet 1(8327), 761 (1983).
    • (1983) Lancet , vol.1 , Issue.8327 , pp. 761
    • Hill, P.1    Garbaczewski, L.2    Wynder, E.L.3
  • 51
    • 0023626378 scopus 로고
    • A comparison of serum and breast duct fluid-immunoassayable prolactin and growth hormone with bioassayable lactogenic hormones in healthy women and patients with cystic breast disease
    • DOI 10.1002/1097-0142(19871201)60:11<2761::AID-CNCR2820601128>3.0. CO;2-I
    • Rose DP, Berke B, Cohen LA, Lahti H. A comparison of serum and breast duct fluid-immunoassayable prolactin and growth hormone with bioassayable lactogenic hormones in healthy women and patients with cystic breast disease. Cancer 60(11), 2761-2765 (1987). (Pubitemid 17161809)
    • (1987) Cancer , vol.60 , Issue.11 , pp. 2761-2765
    • Rose, D.P.1    Berke, B.2    Cohen, L.A.3    Lahti, H.4
  • 52
    • 33645457843 scopus 로고    scopus 로고
    • Estrogen and progesterone levels in nipple aspirate fluid of healthy premenopausal women: Relationship to steroid precursors and response proteins
    • Gann PH, Geiger AS, Helenowski IB, Vonesh EF, Chatterton RT. Estrogen and progesterone levels in nipple aspirate fluid of healthy premenopausal women: relationship to steroid precursors and response proteins. Cancer Epidemiol. Biomarkers Prev. 15(1), 39-44 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , Issue.1 , pp. 39-44
    • Gann, P.H.1    Geiger, A.S.2    Helenowski, I.B.3    Vonesh, E.F.4    Chatterton, R.T.5
  • 53
    • 15944378200 scopus 로고    scopus 로고
    • Comparison of hormone levels in nipple aspirate fluid of pre- And postmenopausal women: Effect of oral contraceptives and hormone replacement
    • Intriguing report on the physiopathological relevance of NAF hormone levels as potential breast cancer risk markers
    • Chatterton RT Jr, Geiger AS, Mateo ET, Helenowski IB, Gann PH. Comparison of hormone levels in nipple aspirate fluid of pre- and postmenopausal women: effect of oral contraceptives and hormone replacement. J. Clin. Endocrinol. Metab. 90(3), 1686-1691 (2005). • Intriguing report on the physiopathological relevance of NAF hormone levels as potential breast cancer risk markers.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , Issue.3 , pp. 1686-1691
    • Chatterton Jr., R.T.1    Geiger, A.S.2    Mateo, E.T.3    Helenowski, I.B.4    Gann, P.H.5
  • 54
    • 26944461183 scopus 로고    scopus 로고
    • The local hormonal environment and related biomarkers in the normal breast
    • DOI 10.1677/erc.1.00732
    • Khan SA, Bhandare D, Chatterton RT Jr. The local hormonal environment and related biomarkers in the normal breast. Endocr. Relat. Cancer 12(3), 497-510 (2005). • Interesting overview integrating informations about cellular and NAF biomarkers of hormone action on the breast to identify breast cancer candidate biomarkers. (Pubitemid 41482990)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.3 , pp. 497-510
    • Khan, S.A.1    Bhandare, D.2    Chatterton Jr., R.T.3
  • 55
    • 61649124894 scopus 로고    scopus 로고
    • New developments in intracrinology of human breast cancer: Estrogen sulfatase and sulfotransferase
    • Updated review on inhibition pathways as endocrine treatment of BC
    • Sasano H, Nagasaki S, Miki Y, Suzuki T. New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase. Ann. NY Acad. Sci. 1155, 76-79 (2009). • Updated review on inhibition pathways as endocrine treatment of BC.
    • (2009) Ann. NY Acad. Sci. , vol.1155 , pp. 76-79
    • Sasano, H.1    Nagasaki, S.2    Miki, Y.3    Suzuki, T.4
  • 56
    • 0019190855 scopus 로고
    • Dehydroepiandrosterone sulphate in breast secretions
    • Miller WR, Humeniuk V, Kelly RW. Dehydroepiandrosterone sulphate in breast secretions. J. Steroid Biochem. 13(2), 145-151 (1980).
    • (1980) J. Steroid Biochem. , vol.13 , Issue.2 , pp. 145-151
    • Miller, W.R.1    Humeniuk, V.2    Kelly, R.W.3
  • 57
    • 0019770189 scopus 로고
    • Factors affecting dehydroepiandrosterone sulphate levels in human breast secretions
    • Miller WR, Humeniuk V, Forrest AP. Factors affecting dehydroepiandrosterone sulphate levels in human breast secretions. Breast Cancer Res. Treat. 1(3), 267-272 (1981).
    • (1981) Breast Cancer Res. Treat. , vol.1 , Issue.3 , pp. 267-272
    • Miller, W.R.1    Humeniuk, V.2    Forrest, A.P.3
  • 59
    • 3042735882 scopus 로고    scopus 로고
    • Intracrinology and the local enzymatic control of hormone distribution and metabolism: Dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens
    • Kuhn-Velten WN. Intracrinology and the local enzymatic control of hormone distribution and metabolism: dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens. Eur. J. Clin. Invest 30(Suppl. 3), 34-38 (2000).
    • (2000) Eur. J. Clin. Invest , vol.30 , Issue.SUPPL. 3 , pp. 34-38
    • Kuhn-Velten, W.N.1
  • 60
    • 0020514518 scopus 로고
    • The metabolism of androstenedione and testosterone to C19 metabolites in normal breast, breast carcinoma and benign prostatic hypertrophy tissue
    • Perel E , Killinger DW. The metabolism of androstenedione and testosterone to C19 metabolites in normal breast, breast carcinoma and benign prostatic hypertrophy tissue. J. Steroid Biochem. 19(2), 1135-1139 (1983).
    • (1983) J. Steroid Biochem. , vol.19 , Issue.2 , pp. 1135-1139
    • Perel, E.1    Killinger, D.W.2
  • 61
    • 0036193923 scopus 로고    scopus 로고
    • Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancer
    • Sauter ER, Tichansky DS, Chervoneva I, Diamandis EP. Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancer. Environ. Health Perspect. 110(3), 241-246 (2002). (Pubitemid 34257189)
    • (2002) Environmental Health Perspectives , vol.110 , Issue.3 , pp. 241-246
    • Sauter, E.R.1    Tichansky, D.S.2    Chervoneva, I.3    Diamandis, E.P.4
  • 62
    • 0023739879 scopus 로고
    • Diet, serum, breast fluid growth hormone, and prolactin levels in normal premenopausal Finnish and American women
    • Rose DP, Boyar AP, Kettunen K. Diet, serum, breast fluid growth hormone, and prolactin levels in normal premenopausal Finnish and American women. Nutr. Cancer 11(3), 179-187 (1988). (Pubitemid 18172958)
    • (1988) Nutrition and Cancer , vol.11 , Issue.3 , pp. 179-187
    • Rose, D.P.1    Boyar, A.P.2    Kettunen, K.3
  • 63
    • 0026463275 scopus 로고
    • Hormones and growth factors in nipple aspirates from normal women and benign breast disease patients
    • Rose DP. Hormones and growth factors in nipple aspirates from normal women and benign breast disease patients. Cancer Detect. Prev. 16(1), 43-51 (1992).
    • (1992) Cancer Detect. Prev. , vol.16 , Issue.1 , pp. 43-51
    • Rose, D.P.1
  • 65
    • 0033406243 scopus 로고    scopus 로고
    • Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; Results from a prospective study
    • Eskelinen M, Kataja V, Hamalainen E, Kosma VM. Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study. Anticancer Res. 19(4C), 3463-3467 (1999). (Pubitemid 30000204)
    • (1999) Anticancer Research , vol.19 , Issue.4 C , pp. 3463-3467
    • Eskelinen, M.1    Kataja, V.2    Hamalainen, E.3    Kosma, V.-M.4
  • 66
    • 0036929890 scopus 로고    scopus 로고
    • Prostate-specific antigen in nipple aspiration fluid: Menstrual cycle variability and correlation with serum prostate-specific antigen
    • DOI 10.1159/000068568
    • Mitchell G, Sibley PE, Wilson AP, Sauter E, A'Hern R, Eeles RA. Prostate-specific antigen in nipple aspiration fluid: menstrual cycle variability and correlation with serum prostate-specific antigen. Tumour Biol. 23(5), 287-297 (2002). (Pubitemid 36302486)
    • (2002) Tumor Biology , vol.23 , Issue.5 , pp. 287-297
    • Mitchell, G.1    Sibley, P.E.C.2    Wilson, A.P.M.3    Sauter, E.4    A'Hern, R.5    Eeles, R.A.6
  • 68
    • 3142704350 scopus 로고    scopus 로고
    • Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancer
    • DOI 10.1016/j.cdp.2003.11.003, PII S0361090X0300206X
    • Sauter ER, Klein G, Wagner-Mann C, Diamandis EP. Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancer. Cancer Detect. Prev. 28(1), 27-31 (2004). (Pubitemid 39403830)
    • (2004) Cancer Detection and Prevention , vol.28 , Issue.1 , pp. 27-31
    • Sauter, E.R.1    Klein, G.2    Wagner-Mann, C.3    Diamandis, E.P.4
  • 69
    • 0032709293 scopus 로고    scopus 로고
    • Molecular forms and ultrastructural localization of prostate-specific antigen in nipple aspirate fluids
    • Mannello F, Malatesta M, Sebastiani M, Battistelli S, Gazzanelli G. Molecular forms and ultrastructural localization of prostate-specific antigen in nipple aspirate fluids. Clin. Chem. 45(12), 2263-2266 (1999).
    • (1999) Clin. Chem. , vol.45 , Issue.12 , pp. 2263-2266
    • Mannello, F.1    Malatesta, M.2    Sebastiani, M.3    Battistelli, S.4    Gazzanelli, G.5
  • 72
    • 0034941839 scopus 로고    scopus 로고
    • Prostate-specific antigen (PSA/hK3): A further player in the field of breast cancer diagnostics?
    • DOI 10.1186/bcr302
    • Mannello F, Gazzanelli G. Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? Breast Cancer Res. 3(4), 238-243 (2001). (Pubitemid 32631703)
    • (2001) Breast Cancer Research , vol.3 , Issue.4 , pp. 238-243
    • Mannello, F.1    Gazzanelli, G.2
  • 73
    • 2542492928 scopus 로고    scopus 로고
    • The selective estrogen enzyme modulators in breast cancer: A review
    • Pasqualini JR. The selective estrogen enzyme modulators in breast cancer: a review. Biochim. Biophys. Acta 1654(2), 123-143 (2004).
    • (2004) Biochim. Biophys. Acta , vol.1654 , Issue.2 , pp. 123-143
    • Pasqualini, J.R.1
  • 74
    • 62949206264 scopus 로고    scopus 로고
    • 17b-hydroxysteroid dehydrogenase enzymes and breast cancer
    • Interesting overview on the estrogen-metabolizing enzymes in the normal breast and the intratumoral synthesis of sex steroids in BC
    • Jansson A. 17b-hydroxysteroid dehydrogenase enzymes and breast cancer. J. Steroid Biochem. Mol. Biol. 114(1-2), 64-67 (2009). •• Interesting overview on the estrogen-metabolizing enzymes in the normal breast and the intratumoral synthesis of sex steroids in BC.
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.114 , Issue.1-2 , pp. 64-67
    • Jansson, A.1
  • 75
    • 37249039273 scopus 로고    scopus 로고
    • The intraductal approach to the breast: Raison d'etre
    • King BL, Love SM. The intraductal approach to the breast: raison d'etre. Breast Cancer Res. 8(2), 206 (2006).
    • (2006) Breast Cancer Res. , vol.8 , Issue.2 , pp. 206
    • King, B.L.1    Love, S.M.2
  • 76
    • 70450025159 scopus 로고    scopus 로고
    • State of the science and the intraductal approach for breast cancer: Proceedings summary of the Sixth International Symposium on the Intraductal Approach to Breast Cancer, Santa Monica, California, 19-21 February 2009
    • Highlights on future perspective of intraductal approaches
    • Rochman S, Mills D, Kim J, Kuerer H, Love S. State of the science and the intraductal approach for breast cancer: proceedings summary of the Sixth International Symposium on the Intraductal Approach to Breast Cancer, Santa Monica, California, 19-21 February 2009. BMC Proc. 3(Suppl. 5), I1 (2009). • Highlights on future perspective of intraductal approaches.
    • (2009) BMC Proc. , vol.3 , Issue.SUPPL. 5
    • Rochman, S.1    Mills, D.2    Kim, J.3    Kuerer, H.4    Love, S.5
  • 77
    • 2542554923 scopus 로고    scopus 로고
    • Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer
    • DOI 10.1055/s-2004-814490
    • Sauter ER, Garofalo C, Hewett J, Hewett JE, Morelli C, Surmacz E. Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. Horm. Metab. Res. 36(5), 336-340 (2004). (Pubitemid 38703795)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.5 , pp. 336-340
    • Sauter, E.R.1    Garofalo, C.2    Hewett, J.3    Hewett, J.E.4    Morelli, C.5    Surmacz, E.6
  • 78
    • 0023936411 scopus 로고
    • Epidermal growth factor-like proteins in breast fluid and human milk
    • Connolly JM , Rose DP. Epidermal growth factor-like proteins in breast fluid and human milk. Life Sci. 42(18), 1751-1756 (1988).
    • (1988) Life Sci. , vol.42 , Issue.18 , pp. 1751-1756
    • Connolly, J.M.1    Rose, D.P.2


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