Mixing order of glidant and lubricant - Influence on powder and tablet properties

International Journal of Pharmaceutics

Volumn 409, Issue 1-2, 2011, Pages 269-277

  Pingali, Kalyana ^a   Mendez, Rafael ^a   Lewis, Daniel ^a   Michniak Kohn, Bozena ^b   Cuitino, Alberto ^b   Muzzio, Fernando ^a  

^a The State University of New Jersey   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Dissolution; Drug release; Hydrophobicity; Mixing order; Shear; Strain

Indexed keywords

AEROSIL; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PARACETAMOL;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG MIXTURE; DRUG SYNTHESIS; FLOW KINETICS; HYDROPHOBICITY; POWDER FORMULATION; PRIORITY JOURNAL; SHEAR RATE; TABLET FORMULATION;

ACETAMINOPHEN; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; HARDNESS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTOSE; LUBRICANTS; POWDERS; SILICON DIOXIDE; SOLUBILITY; STEARIC ACIDS; TABLETS;

EID: 79955038866     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.02.032     Document Type: Article

References (35)

1. M.D. Bastos, R.B. Friedrich, and R.C.R. Beck Effects of filler-binders and lubricants on physicochemical properties of tablets obtained by direct compression: a 2(2) factorial design Lat. Am. J. Pharm. 27 2008 578 583
2. G.K. Bolhuis, A.C. Eissens, T.P. Adrichem, J.A. Wesselingh, and H.W. Frijlink Hollow filler-binders as excipients for direct compaction Pharm. Res. 20 2003 515 518 (Pubitemid 36288385)
3. G.K. Bolhuis, and A.W. Holzer Lubricant sensitivity G. Alderborn, C. Nystrom, Pharm. Pow. Compact. Technol. 1996 Marcel Dekker New York, NY, USA 517 560
4. G.K. Bolhuis, S.W. Jong, and C.F. Lerk The effect of magnesium stearate admixing in different types of laboratory and industrial mixers on tablet crushing strength Drug Dev. Ind. Pharm. 13 1987 1547 1567
5. Z.T. Chowhan Role of binders in moisture-induced hardness increase in compressed tablets and its effect on in vitro disintegration and dissolution J. Pharm. Sci. 69 1980 1
6. Z.T. Chowhan, and I.C. Yang Powder flow studies IV, tensile strength and flow rate relationships of binary mixture Int. J. Pharm. 14 1983 231 242 (Pubitemid 13112236)
7. M.H. El-Shabouri Use of binary and ternary mixtures of magnesium stearate, talc and colloidal silica for preparing sustained-release tablets of a high loading-dose drug Pharm. Ind. 65 2003 1283 1287 (Pubitemid 38089522)
8. A. Faqih, B. Chaudhuri, A.W.A. Alexander, S. Hammond, F.J. Muzzio, and M.S. Tomassone Dilation effects of cohesive granular material in a rotating drum: experiments and simulations AlChE J. 52 2006 4124 4132
9. J.A. Hersey Ordered mixing: a new concept in powder mixing practice Powder Technol. 11 1975 41 44
10. M.S.H. Hussain, P. York, and P. Timmins A study of the formation of magnesium stearate film on sodium chloride using energy-dispersive X-ray analysis Int. J. Pharm. 42 1988 89 95 (Pubitemid 18092096)
11. M.E. Johansson, and M. Nicklasson Investigation of the film formulation of magnesium stearate by applying a flow-through dissolution technique J. Pharm. Pharmacol. 38 1986 51 54 (Pubitemid 16175588)
12. M.A. Khan, A.A. Karnachi, and S.K. Singh Controlled-release coprecipitates - formulation considerations J. Control. Release 37 1995 131 141
13. J. Kikuta, and N. Kitamori Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets Drug Dev. Ind. Pharm. 20 1994 343 355 (Pubitemid 24095375)
14. S.A. Kucera, D. Stimpel, and N.H. Shah Influence of fumed silicon dioxide on the stabilization of Eudragit (R) RS/RL 30 D film-coated theophylline pellets Pharm. Dev. Technol. 13 2008 245 253 (Pubitemid 351882246)
15. B.J. Lee, S.G. Ryu, and J.H. Cui Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin Drug Dev. Ind. Pharm. 25 1999 493 501
16. M. Levina, and A.R. Rajabi-Siahboomi The influence of excipients on drug release from hydroxypropyl methylcellulose matrices J. Pharm. Sci. 93 2004 2746 2754 (Pubitemid 39506625)
17. N.O. Lindberg, A. Berdal, and G. Enstad Investigation of flow properties of powders by means of a uniaxial tester, in relation to direct tablet compression Drug Dev. Ind. Pharm. 28 2002 15 28 (Pubitemid 34274556)
18. M.D. Louey, S. Razia, and P.J. Stewart Influence of physico-chemical carrier properties on in vitro deposition from interactive mixtures Int. J. Pharm. 252 2003 87 98 (Pubitemid 36126617)
19. M.D. Louey, and P.J. Stewart Particle interactions involved in aerosol dispersion of ternary interactive mixtures Pharm. Res. 19 2002 1524 1531 (Pubitemid 35266558)
20. M. Mehrotra, M. Llusa, A. Faqih, M. Levin, and F.J. Muzzio Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate Int. J. Pharm. 336 2007 284 291 (Pubitemid 46670655)
21. K.M. Ohta, M. Fuji, and M. Chikazawa Effect of geometric structure of flow promoting agents on the flow properties of pharmaceutical powder mixture Pharm. Res. 20 2003 804 809 (Pubitemid 36515315)
22. K.M. Ohta, M. Fuji, and T. Takei Effect of geometric structure and surface wettability of glidant on tablet hardness Int. J. Pharm. 262 2003 75 82 (Pubitemid 36966695)
23. S.I. Pather, I. Russell, and J.A. Syce Sustained release theophylline tablets by direct compression. Part 1. Formulation and in vitro testing Int. J. Pharm. 164 1998 1 10 (Pubitemid 28160092)
24. Pingali, K.C., Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J., 2010. Evaluation of shear induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. Drug Dev. Ind. Pharm., in press.
25. K.C. Pingali, K. Saranteas, R. Foroughi, and F.J. Muzzio Practical methods for improving flow properties of active pharmaceutical ingredients Drug Dev. Ind. Pharm. 35 2009 1460 1469
26. K.C. Pingali, M.S. Tomassone, and F.J. Muzzio Effects of shear and electrical properties on flow characteristics of pharmaceutical blends J. AIChE 56 2010 570 583
27. M. Roberts, J.L. Ford, and G.S. MacLeod Effect of lubricant type and concentration on the punch tip adherence of model ibuprofen formulations J. Pharm. Pharmacol. 56 2004 299 305 (Pubitemid 38380211)
28. A. Sabir, B. Evans, and S. Jain Formulation and process optimization to eliminate picking from market image tablets Int. J. Pharm. 215 2001 123 135 (Pubitemid 32206610)
29. P.J. Sheskey, R.T. Robb, and R.D. Moore Effects of lubricant level, method of mixing, and duration of mixing on a controlled-release matrix tablet containing hydroxypropyl methylcellulose Drug Dev. Ind. Pharm. 21 1995 2151 2165
30. S. Sundell-Bredenberg, and C. Nystrom The possibility of achieving an interactive mixture with high dose homogeneity containing an extremely low proportion of a micronised drug Eur. J. Pharm. Sci. 12 2001 285 295
31. B. Van Veen, G.K. Bolhuis, and Y.S. Wu Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose Eur. J. Pharm. Biopharm. 59 2005 133 138 (Pubitemid 39573445)
32. N. Wakiyama, A. Kusai, and K. Nishimura Fine solid additives increase cohesiveness of granules containing oily materials STP Pharm. Sci. 4 1994 387 393 (Pubitemid 24380392)
33. E.W. Washburn The dynamics of capillary flow Phys. Rev. 17 1921 273 283
34. J. Yang, A. Sliva, A. Banerjee, R.N. Dave, and R. Pfeffer Dry particle coating for improving the flowability of cohesive powders Powder Technol. 158 2005 21 33 (Pubitemid 41376283)
35. Q. Zhang, J. Yang, S.L. Teng, R.N. Dave, L.J. Zhu, P. Wang, M.W. Young, and C.G. Gogos In-situ, simultaneous milling and coating of particulates with nanoparticles Powder Technol. 196 2009 292 297