Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat

Neuroscience Letters

Volumn 298, Issue 1, 2001, Pages 1-4

  Kane, J K ^a   Parker, S L ^a   Li, M D ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Nicotine; Orexin; Receptor regulation

Indexed keywords

ADENYLATE CYCLASE; NEUROPEPTIDE Y RECEPTOR; NICOTINE; OREXIN A; SECRETIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOKING;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CARRIER PROTEINS; DOWN-REGULATION; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035951685     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01730-4     Document Type: Article

References (20)

1. Neuropeptide Y distribution in the rat brain
2. Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells
3. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
4. Downregulation of the oxytocin receptor on cultured astroglial cells
5. Turning off the signal: Mechanisms that attenuate signaling by G protein-coupled receptors
6. Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration
7. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
8. Nicotine up-regulates expression of orexin and its receptors in rat brain
9. Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin
10. Nonsaturable entry of neuropeptide Y into brain
11. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion
12. Nicotine administration enhances NPY expression in the rat hypothalamus
13. Regulation of feeding and feeding-associated peptides and receptors by nicotine
14. Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models
15. Characterization of G-protein and phospholipase C - coupled agonist binding to the Y1 neuropeptide Y receptor in rat brain. Sensitivity to G-protein activators and inhibitors and to inhibitors of phospholipase C
16. FMRFamides exert a unique modulation of rodent pancreatic polypeptide sensitive neuropeptide Y (NPY) receptors
17. Decreased neuropeptide Y (NPY) Y1 receptors in hypothalamus of rats treated with nicotine: Evidence for downregulation of a specific population of sites
18. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
19. Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
20. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight