Impaired cellular immune response to diphtheria and tetanus vaccines in children after thoracic transplantation

Pediatric Transplantation

Volumn 15, Issue 3, 2011, Pages 272-280

  Urschel, Simon ^a,b,c   Rieck, Birgit D ^b   Birnbaum, Julia ^a   Dalla Pozza, Robert ^a   Rieber, Nikolaus ^b   Januszewska, Katarzyna ^a   Fuchs, Alexandra ^a   West, Lori J ^c   Netz, Heinrich ^a   Belohradsky, Bernd H ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

adverse events; immune response; immunization; immunosuppression; infectious risks; pediatric heart transplantation

Indexed keywords

AZATHIOPRINE; BACTERIUM ANTIBODY; CYCLOSPORIN A; DIPHTHERIA VACCINE; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MEPREDNISONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS; TETANUS TOXOID;

ADOLESCENT; ADULT; AGE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL IMMUNITY; BREATHING; CD4+ T LYMPHOCYTE; CELL ASSAY; CELL PROLIFERATION; CELL STIMULATION; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIPHTHERIA; DOSE RESPONSE; DRUG ERUPTION; DRUG FEVER; DRUG INDUCED HEADACHE; DYSPNEA; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INJECTION SITE ERYTHEMA; INJECTION SITE PAIN; INJECTION SITE SWELLING; LETHARGY; LUNG TRANSPLANTATION; LYMPHOCYTE; MALAISE; MEDICAL HISTORY; MONOTHERAPY; MYALGIA; PEDIATRIC SURGERY; PRESCHOOL CHILD; SCHOOL CHILD; SIDE EFFECT; SLEEP DISORDER; T LYMPHOCYTE ACTIVATION; TETANUS; VERTIGO;

ADOLESCENT; ADULT; ANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; DIPHTHERIA TOXOID; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNE SYSTEM; IMMUNIZATION, SECONDARY; IMMUNOSUPPRESSIVE AGENTS; LUNG TRANSPLANTATION; MALE; T-LYMPHOCYTES; TETANUS TOXOID;

EID: 79955018497     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01468.x     Document Type: Article

References (29)

1. Fonseca-Aten M, Michaels MG,. Infections in pediatric solid organ transplant recipients. Semin Pediatr Surg 2006: 15: 153-161. (Pubitemid 43963385)
2. Stovall SH, Ainley KA, Mason EO Jr, et al., Invasive pneumococcal infections in pediatric cardiac transplant patients. Pediatr Infect Dis J 2001: 20: 946-950. (Pubitemid 32952671)
3. Mauch TJ, Bratton S, Myers T, Krane E, Gentry SR, Kashtan CE,. Influenza B virus infection in pediatric solid organ transplant recipients. Pediatrics 1994: 94: 225-229. (Pubitemid 24236145)
4. Urschel S, Cremer S, Birnbaum J, et al., Lack of serologic immunity against vaccine-preventable diseases in children after thoracic transplantation. Transpl Int 2010: 23: 619-627.
5. Pedrazzi C, Ghio L, Balloni A, et al., Duration of immunity to diphtheria and tetanus in young kidney transplant patients. Pediatr Transplant 1999: 3: 109-114. (Pubitemid 29274413)
6. Gennery AR, Cant AJ, Spickett GP, et al., Effect of immunosuppression after cardiac transplantation in early childhood on antibody response to polysaccharide antigen. Lancet 1998: 351: 1778-1781. (Pubitemid 28269189)
7. Wagner D, Wagenbreth I, Stachan-Kunstyr R, Thoma HA, Hemmerling AE, Flik J,. Hepatitis B vaccination of immunosuppressed heart transplant recipients with the vaccine Hepa Gene 3 containing pre-S1, pre-S2, and S gene products. Clin Invest 1994: 72: 350-352. (Pubitemid 24171920)
8. Kroger AT, Atkinson WL, Marcuse EK, Pickering LK,. General recommendations on immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006: 55: 1-48.
9. Cainelli F, Vento S,. Infections and solid organ transplant rejection: A cause-and-effect relationship? Lancet Infect Dis 2002: 2: 539-549. (Pubitemid 34966357)
10. S tändige I mpfkommission des R obert K och I nstituts (STIKO). National Recommendations for Vaccination [Impfempfehlungen der Ständigen Impfkommision]. Epidemiologisches Bulletin 2005: 30: 257-272.
11. Schneerson R,. Similarities between the pathogenesis of and immunity to diphtheria and pertussis: The complex nature of serum antitoxin-induced immunity to these two diseases. Clin Infect Dis 1999: 28 (Suppl 2): S136-S139. (Pubitemid 29270383)
12. Krüger S, Müller-Steinhardt M, Kirchner H, Kreft B,. A 5-year follow-up on antibody response after diphtheria and tetanus vaccination in hemodialysis patients. Am J Kidney Dis 2001: 38: 1264-1270. (Pubitemid 34193112)
13. Fraund S, Wagner D, Pethig K, Drescher J, Girgsdies OE, Haverich A,. Influenza vaccination in heart transplant recipients. J Heart Lung Transplant 1999: 18: 220-225. (Pubitemid 29177899)
14. Candon S, Thervet E, Lebon P, et al., Humoral and cellular immune responses after influenza vaccination in kidney transplant recipients. Am J Transplant 2009: 9: 2346-2354.
15. Madan RP, Tan M, Fernandez-Sesma A, et al., A prospective, comparative study of the immune response to inactivated influenza vaccine in pediatric liver transplant recipients and their healthy siblings. Clin Infect Dis 2008: 46: 712-718. (Pubitemid 351321555)
16. Carter LL, Swain SL,. Single cell analyses of cytokine production. Curr Opin Immunol 1997: 9: 177-182. (Pubitemid 27190115)
17. Afzali B, Lombardi G, Lechler RI, Lord GM,. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007: 148: 32-46. (Pubitemid 46365005)
18. Rieber N, Graf A, Belohradsky BH, et al., Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination. Vaccine 2008: 26: 6929-6935.
19. Piersma SJ, Leenaars MP, Guzylack-Piriou L, Summerfield A, Hendriksen CF, Mccullough KC,. An in vitro immune response model to determine tetanus toxoid antigen (vaccine) specific immunogenicity: Selection of sensitive assay criteria. Vaccine 2006: 24: 3076-3083.
20. Zepp F, Knuf M, Habermehl P, et al., Cell-mediated immunity after pertussis vaccination and after natural infection. Dev Biol Standard 1997: 89: 307-314.
21. Scott LJ, Mckeage K, Keam SJ, Plosker GL,. Tacrolimus: A further update of its use in the management of organ transplantation. Drugs 2003: 63: 1247-1297. (Pubitemid 36750952)
22. Budde K, Fritsche L, Mai I, et al., Clinical pharmacokinetics of tacrolimus in rescue therapy after renal transplantation. Int J Clin Pharmacol Ther 1996: 34: 493-497. (Pubitemid 26386035)
23. Kowalski R, Post D, Schneider MC, et al., Immune cell function testing: An adjunct to therapeutic drug monitoring in transplant patient management. Clin Transpl 2003: 17: 77-88. (Pubitemid 36833776)
24. Vidhun JR, Sarwal MM,. Corticosteroid avoidance in pediatric renal transplantation. Pediatr Nephrol 2005: 20: 418-426. (Pubitemid 40309954)
25. Meiser B, Kaczmarek I, Mueller M, et al., Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious. J Heart Lung Transplant 2007: 26: 598-603. (Pubitemid 46818048)
26. Singh TP, Faber C, Blume ED, et al., Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipients. J Heart Lung Transplant 2010: 29: 517-522.
27. Ameduri RK, Canter CE,. Current practice in immunosuppression in pediatric cardiac transplantation. Prog Pediatr Cardiol 2009: 26: 31-37.
28. Rossano JW, Denfield SW, Kim JJ, et al., Assessment of the Cylex ImmuKnow cell function assay in pediatric heart transplant patients. J Heart Lung Transplant 2009: 28: 26-31.
29. Kimball P, Verbeke S, Flattery M, Rhodes C, Tolman D,. Influenza vaccination does not promote cellular or humoral activation among heart transplant recipients. Transplantation 2000: 69: 2449-2451. (Pubitemid 30409021)