Unpaired extinction: Implications for treating post-traumatic stress disorder

Journal of Psychiatric Research

Volumn 45, Issue 5, 2011, Pages 638-649

  Schreurs, Bernard G ^a   Smith Bell, Carrie A ^a   Burhans, Lauren B ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Classical conditioning; Fear; Heart rate; Nictitating membrane response; Rabbit; Relapse

Indexed keywords

AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; ELECTROSTIMULATION; FEAR; MALE; NICTITATING MEMBRANE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; STIMULUS;

EID: 79955008151     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2010.10.010     Document Type: Article

References (65)

1. Beck J.G., Palyo S.A., Winer E.H., Schwagler B.E., Ang E.J. Virtual reality exposure therapy for PTSD symptoms after a road accident: an uncontrolled case series. Behavior Therapy 2007, 38:39-48.
2. Boscarino J.A. Posttraumatic stress disorder and mortality among U.S. army veterans 30 years after military service. Annals of Epidemiology 2005, 16:248-256.
3. Bouton M.E., Westbrook R.F., Corcoran K.A., Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biological Psychiatry 2006, 60:352-360.
4. Brunijnzeel A.W., Stam R., Croiset G., Wiegant V.M. Long-term sensitization of cardiovascular stress responses after a single stressful experience. Physiology & Behavior 2001, 73:81-86.
5. Buck D.L., Seager M.A., Schreurs B.G. Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: generality and nature of the phenomenon. Behavioral Neuroscience 2001, 115:1039-1047.
6. Burhans L.B., Smith-Bell C.A., Schreurs B.G. Conditioning-specific reflex modification of the rabbit's nictitating membrane response and heart rate: behavioral rules, neural substrates, and potential applications to post-traumatic stress disorder. Behavioral Neuroscience 2008, 122:1191-1206.
7. Burhans L.B., Smith-Bell C.A., Schreurs B.G. Effects of extinction on classical conditioning and conditioning-specific reflex modification of rabbit heart rate. Behavioural Brain Research 2009, 206:127-134.
8. Chang C.-H., Knapska E., Orsini C.A., Rabinak C.A., Zimmerman J.M., Maren S. Fear extinction in rodents. Current Protocols in Neuroscience 2009, 47:8.23.1-8.23.17.
9. Coleman S.R., Gormezano I. Classical conditioning of the rabbit's (Oryctolagus cuniculus) nictitating membrane response under symmetrical CS-US interval shifts. Journal of Comparative and Physiological Psychology 1971, 77:447-455.
10. Colwill R.M. Effects of US identity on elimination and recovery of autoshaped responding with explicitly unpaired and degraded contingency extinction procedures. Behavioural Processes 2007, 74:1-12.
11. Cukor J., Spitalnick J., Difede J., Rizzo A., Rothbaum B.O. Emerging treatments for PTSD. Clinical Psychology Review 2009, 29:715-726.
12. Dierperink M., Erbes C., Leskela J., Kaloupek D., Farrer M.K., Fisher L., et al. Comparison of treatment for post-traumatic stress disorder among three Department of Veterans Affairs medical centers. Military Medicine 2005, 170:305-308.
13. Dobbs D., Wilson W.P. Observations on persistence war neurosis. Diseases of the Nervous System 1960, 21:686-691.
14. Duan Y.-F., Winters R.W., McCabe P.M., Green E.J., Huang Y., Schneiderman N. Cardiorespiratory components of defense reaction elicited from paraventricular nucleus. Physiology & Behavior 1997, 61:325-330.
15. Elsesser K., Sartory G., Tackenberg A. Attention, heart rate, and startle response during exposure to trauma-related pictures: a comparison of recent trauma victims and patients with posttraumatic stress disorder. Journal of Abnormal Psychology 2004, 113:289-301.
16. English B.A., Jewell M., Jewell G., Ambrose S., Davis L.L. Treatment of chronic posttraumatic stress disorder in combat veterans with citalopram. Journal of Clinical Psychopharmacology 2006, 26:84-88.
17. Flaten M.A., Blumenthal T.D. A parametric study of the separate contributions of the tactile and acoustic components of airpuffs to the blink reflex. Biological Psychology 1998, 48:227-234.
18. Frey P.W., Butler C.S. Extinction after aversive conditioning: an associative or nonassociative process?. Learning and Motivation 1977, 8:1-17.
19. Gerardi M., Cukor J., Difede J., Rizzo A., Rothbaum B.O. Virtual reality exposure therapy for post-traumatic stress disorder and other anxiety disorders. Current Psychiatry Reports 2010, 12:298-305.
20. Gormezano I. Classical conditioning. Experimental methods and instrumentation in psychology 1966, 385-420. McGraw-Hill, New York. J.B. Sidowski (Ed.).
21. Gormezano I., Gibbs C.M. Transduction of the rabbit's nictitating membrane response. Behavior Research Methods, Instruments, & Computers 1988, 20:18-21.
22. Gracia K.S., Mauk M.D., Weidemann G., Kehoe E.J. Covariation of alternative measures of responding in rabbit (Oryctolagus cuniculus) eyeblink conditioning during acquisition training and tone generalization. Behavioral Neuroscience 2003, 117:292-303.
23. Graham F.K., Clifton R.K. Heart-rate change as a component of the orienting response. Psychological Bulletin 1966, 65:305-320.
24. Grahn R.E., Watkins L.R., Maier S.F. Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrolled stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus. Behavioural Brain Research 2000, 112:33-41.
25. Gruart A., Yeo C.H. Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses. Experimental Brain Research 1995, 104:431-448.
26. Hayes E., Pugsley M.K., Penz W.P., Adaikan G., Walker M.J.A. Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates. Journal of Pharmacological and Toxicological Methods 1994, 32:201-207.
27. Hofmann S.G. Cognitive processes during fear conditioning and extinction in animals and humans: implications for exposure therapy for anxiety disorders. Clinical Psychology Review 2008, 28:199-210.
28. Hoge C.W., Auchterloine J.L., Milliken C.S. Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan. JAMA 2006, 295:1023-1032.
29. Kehoe E.J., Weidemann G., Dartnall S. Apparatus exposure produces profound declines in conditioned nictitating-membrane responses to discrete conditioned stimuli by the rabbit. Journal of Experimental Psychology: Animal Behavior Processes 2004, 30:259-270.
30. Leonard D.W. Partial reinforcement effects in classical conditioning in rabbits and human beings. Journal of Comparative and Physiological Psychology 1975, 88:596-608.
31. McEchron M.D., McCabe P.M., Green E.J., Llabre M.M., Schneiderman N. Air puff versus shock unconditioned stimuli in rabbit heart rate conditioning. Physiology & Behavior 1991, 51:195-199.
32. McNally R.J. Mechanisms of exposure therapy: how neuroscience can improve psychological treatments for anxiety disorders. Clinical Psychology Review 2007, 27:750-759.
33. Mickley G.A., DiSorbo A., Wilson G.N., Huffman J., Bacik S., Hoxha Z., et al. Explicit dissociation of a conditioned stimulus and unconditioned stimulus during extinction training reduces both time to asymptotic extinction and spontaneous recovery of a conditioned taste aversion. Learning and Motivation 2009, 40:209-220.
34. Milad M.R., Rauch S.L., Pitman R.K., Quirk G.J. Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biological Psychiatry 2006, 73:61-71.
35. Nijsen M.J.M.A., Croiset G., Diamant M., Stam R., Delsing D., de Wied D., et al. Conditioned fear-induced tachycardia in the rat; vagal involvement. European Journal of Pharmacology 1998, 350:211-222.
36. Orr S.P., Metzger L.J., Lasko N.B., Macklin M.L., Peri T., Pitman R.K. De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. Journal of Abnormal Psychology 2000, 109:290-298.
37. Orr S.P., Metzger L.J., Pitman R.K. Psychophysiology of post-traumatic tress disorder. Psychiatric Clinics of North America 2002, 25:271-293.
38. Oswald B.B., Knuckley B., Mahan K., Sanders C., Powell D.A. Prefrontal control of trace versus delay eyeblink conditioning: role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus). Behavioral Neuroscience 2006, 120:1033-1042.
39. Pitman R.K. Post-traumatic stress disorder, conditioning, and network theory. Psychiatric Annals 1988, 18:182-189.
40. Pitman R.K., Gilbertson M.W., Gurvits T.V., May F.S., Lasko N.B., Metzger L.J., et al. Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure. Annals New York Academy of Sciences 2006, 1071:242-254.
41. Pitman R.K., Orr S.P., Shalev A.Y. Once bitten, twice shy: beyond the conditioning model of PTSD. Biological Psychiatry 1993, 33:145-146.
42. Pole N., Neylan T.C., Otte C., Henn-Hasse C., Metzler T.J., Marmar C.R. Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biological Psychiatry 2009, 65:235-240.
43. Powell D.A., Gibbs C.M., Maxwell B., Levine-Bryce D. On the generality of the conditioned bradycardia in rabbits: assessment of CS and US modality. Animal Learning & Behavior 1993, 21:303-313.
44. Powell D.A., Maxwell B., Penney J. Neuronal activity in the medial prefrontal cortex during Pavlovian eyeblink and nictitating membrane conditioning. Journal of Neuroscience 1996, 16:6296-6306.
45. Raskin D.C. Orienting and defensive reflexes and conditioning. Classical conditioning II: current research and theory 1972, 269-289. Appleton-Century-Crofts, New York. A.H. Black, W.F. Prokasy (Eds.).
46. Raskin D.C., Kotses H., Bever J. Autonomic indicators of orienting and defensive reflexes. Journal of Experimental Psychology 1969, 80:423-433.
47. Rauhut A.S., Thomas B.L., Ayres J.J.B. Treatments that weaken Pavlovian conditioned fear and thwart its renewal in rats: implications for treating human phobias. Journal of Experimental Psychology: Animal Behavior Processes 2001, 27:99-114.
48. Riccio D.C., Millin P.M., Bogart A.R. Reconsolidation: a brief history, a retrieval view, and some recent issues. Learning & Memory 2006, 13:536-544.
49. Richter A., Schumann N.P., Zweiner U. Characteristics of heart rate fluctuations and respiratory movements during orienting, passive avoidance and flight-fight behavior in rabbits. International Journal of Psychophysiology 1990, 10:75-83.
50. Rothbaum B.O., Hodges L.F., Ready D., Graap K., Alarcon R.D. Virtual reality exposure therapy for Vietnam veterans with posttraumatic stress disorder. Journal of Clinical Psychiatry 2001, 62:617-622.
51. Schadt J.C., Hasser E.M. Hemodynamic effects of acute stressors in the conscious rabbit. American Journal of Physiology Regulatory Integrative Comparative Physiology 1998, 274:R814-R821.
52. Schreurs B.G. Classical conditioning and modification of the rabbit's (Oryctolagus cuniculus) unconditioned nictitating membrane response. Behavioral and Cognitive Neuroscience Reviews 2003, 2:83-96.
53. Schreurs B.G., Alkon D.L. US-US conditioning of the rabbit's nictitating membrane response: emergence of a conditioned response without alpha conditioning. Psychobiology 1990, 18:312-320.
54. Schreurs B.G., Crum J.M., Wang D., Smith-Bell C.A. Conditioning-specific reflex modification of rabbit (Oryctolagus cuniculus) heart rate. Behavioral Neuroscience 2005, 119:1484-1495.
55. Schreurs B.G., Gonzales-Joekes J., Smith-Bell C.A. Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response is sensitive to context. Learning & Behavior 2006, 34:315-324.
56. Schreurs B.G., Oh M.M., Hirashima C., Alkon D.L. Conditioning-specific modification of the rabbit's unconditioned nictitating membrane response. Behavioral Neuroscience 1995, 109:24-33.
57. Schreurs B.G., Shi T., Pineda S.I., Buck D.L. Conditioning the unconditioned response: modification of the rabbit's (Oryctolagus cuniculus) unconditioned nictitating membrane response. Journal of Experimental Psychology: Animal Behavior Processes 2000, 26:144-156.
58. Schreurs B.G., Smith-Bell C.A. Heart rate changes during conditioning-specific reflex modification of the rabbit's (Oryctolagus cuniculus) nictitating membrane response. Neurobiol.Learn.Mem 2005, 84:148-158.
59. Schreurs B.G., Smith-Bell C.A., Darwish D.S., Wang D., Burhans L., Gonzales-Joekes J., et al. Cholesterol enhances classical conditioning of the rabbit heart rate response. Behavioural Brain Research 2007, 181:52-63.
60. Seager M.A., Smith-Bell C.A., Schreurs B.G. Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: US intensity effects. Learning & Behavior 2003, 31:292-298.
61. Shalev A.Y., Peri T., Brandes D., Freedman S., Orr S.P., Pitman R.K. Auditory startle response in trauma survivors with posttraumatic stress disorder: a prospective study. American Journal of Psychiatry 2000, 157:255-261.
62. Spence K.W. Extinction of the human eyelid CR as a function of presence or absence of the UCS during extinction. Journal of Experimental Psychology 1966, 71:642-648.
63. Thomas B.L., Longo C.L., Ayres J.J.B. Thwarting the renewal (relapse) of conditioned fear with the explicitly unpaired procedure: possible interpretations and implications for treating human fears and phobias. Learning and Motivation 2005, 36:374-407.
64. Vervleit B., Vansteenwegen D., Hermans D. Unpaired shocks during extinction weaken the contextual renewal of a conditioned discrimination. Learning and Motivation 2010, 41:22-31.
65. Wikgren J., Ruusuvirta T., Korhonen T. Reflex facilitation during eyeblink conditioning and subsequent interpositus nucleus inactivation in the rabbit (Oryctolagus cuniculus). Behavioral Neuroscience 2002, 116:1052-1058.