The Chernobyl Accident - An Epidemiological Perspective

Clinical Oncology

Volumn 23, Issue 4, 2011, Pages 251-260

  Cardis, E ^a   Hatch, M ^b  

^a HOSPITAL DEL MAR   (Spain)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; Cardiovascular diseases; Cataracts; Chernobyl accident; Radiation; Thyroid cancer

Indexed keywords

RADIOACTIVE IODINE;

AGE; ARTICLE; BREAST CANCER; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CARDIOVASCULAR DISEASE; CATARACT; CHERNOBYL ACCIDENT; CHILDHOOD CANCER; DOSE RESPONSE; GENDER; HUMAN; LEUKEMIA; LYMPHATIC LEUKEMIA; ONCOGENE; ONCOGENE RET; OVARY CANCER; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INDUCED NEOPLASM; RADIATION RESPONSE; SUBCAPSULAR CATARACT; THYROID CANCER; THYROID PAPILLARY CARCINOMA;

ADOLESCENT; ADULT; CARDIOVASCULAR DISEASES; CATARACT; CHERNOBYL NUCLEAR ACCIDENT; CHILD; FEMALE; HUMANS; INCIDENCE; MALE; NEOPLASMS, RADIATION-INDUCED; RADIATION INJURIES; RADIOACTIVE FALLOUT; RISK FACTORS; THYROID NEOPLASMS; TIME FACTORS; UKRAINE; YOUNG ADULT;

EID: 79954993372     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2011.01.510     Document Type: Article

References (85)

1. Health effects of the Chernobyl accident and special health care programmes. World Health Organisation report of the UN Chernobyl Forum expert group "Health" (EGH) 2006, UN Chernobyl Forum, World Health Organization, Geneva. B. Bennett, M. Repacholi, Z. Carr (Eds.).
2. United Nations. Sources and effects of ionizing radiation. Report to the General Assembly. Scientific Annexes C, D and E, UNSCEAR 2008 Report 2011, vol. II. New York: United Nations.
3. Wood J.W., Tamagaki H., Neriishi S., et al. Thyroid carcinoma in atomic bomb survivors Hiroshima and Nagasaki. Am J Epidemiol 1969, 89(1):4-14.
4. Sources and effects of ionizing radiation. Effects 2000, vol. II. UNSCEAR, New York: United Nations.
5. Imaizumi M., Ashizawa K., Neriishi K., et al. Thyroid diseases in atomic bomb survivors exposed in utero. J Clin Endocrinol Metab 2008, 93(5):1641-1648.
6. Ron E., Lubin J.H., Shore R.E., et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 1995, 141(3):259-277.
7. Thompson D.E., Mabuchi K., Ron E., et al. Cancer incidence in atomic bomb survivors. Part II: solid tumors, 1958-1987. Radiat Res 1994, 137(2 Suppl.):S17-S67.
8. Hall P., Adami H.O. Thyroid cancer. Textbook of cancer epidemiology 2002, 504-519. Oxford University Press, New York. H.O. Adami, D. Hunter, D. Trichopoulos (Eds.).
9. Dickman P.W., Holm L.E., Lundell G., Boice J.D., Hall P. Thyroid cancer risk after thyroid examination with 131I: a population-based cohort study in Sweden. Int J Cancer 2003, 106(4):580-587.
10. Holm L.E., Wiklund K.E., Lundell G.E., et al. Thyroid cancer after diagnostic dose of iodine-131: a retrospective cohort study. J Natl Cancer Inst 1988, 80:1132-1138.
11. Hall P., Berg G., Bjelkengren G., et al. Cancer mortality after iodine-131 therapy for hyperthyroidism. Int J Cancer 1992, 50:886-890.
12. Prisyazhiuk A., Pjatak O.A., Buzanov V.A., Reeves G.K., Beral V. Cancer in the Ukraine, post-Chernobyl. Lancet 1991, 338:1334-1335.
13. Kazakov V.S., Demidchik E.P., Astakhova L.N. Thyroid cancer after Chernobyl. Nature 1992, 359:21.
14. Baverstock K., Egloff B., Pinchera A., Ruchti C., Williams D. Thyroid cancer after Chernobyl. Nature 1992, 359(6390):21-22.
15. Sources and effects of ionizing radiation. UNSCEAR 1988 Report 1988, UNSCEAR, UNSCEAR, New York.
16. Thyroid cancer in children after the Chernobyl accident: clinical and epidemiological evaluation of 251 cases in the Republic of Belarus 1994, Elsevier Science, Amsterdam. S. Nagataki (Ed.).
17. Tronko N.D., Epstein Y., Oleinik V. Thyroid gland in children after the Chernobyl accident (yesterday and today). Nagasaki symposium on Chernobyl: update and future 1994, 3-46. Elsevier Science, Amsterdam. S. Nagataki (Ed.).
18. Farahati J., Demidchik E.P., Biko J., Reiners C. Inverse association between age at the time of radiation exposure and extent of disease in cases of radiation-induced childhood thyroid carcinoma in Belarus. Cancer 2000, 88(6):1470-1476.
19. Reiners C., Demidchik Y.E. Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Pediatr Endocrinol Rev 2003, 1(Suppl. 2):230-235.
20. Thomas G.A., Bunnell H., Cook H.A., et al. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 1999, 84(11):4232-4238.
21. Likhtarev I., Kovgan L., Vavilov S., et al. Post-Chornobyl thyroid cancer in Ukraine. Report 2: risk anaysis. Radiat Res 2006, 166(2):375-386.
22. Jacob P., Bogdanova T.I., Buglova E., et al. Thyroid cancer risk in areas of Ukraine and Belarus affected by the Chernobyl accident. Radiat Res 2006, 165(1):1-8.
23. Shakhtarin V.V., Tsyb A.F., Stepanenko V.F., Orlov M.Y., Kopecky K.J., Davis S. Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident. Int J Epidemiol 2003, 32(4):584-591.
24. Astakhova L.N., Anspaugh L.R., Beebe G.W., et al. Chernobyl-related thyroid cancer in children of Belarus: a case-control study. Radiat Res 1998, 150(3):349-356.
25. Davis S., Stepanenko V., Rivkind N., et al. Risk of thyroid cancer in the Bryansk oblast of the Russian Federation after the Chernobyl power station accident. Radiat Res 2004, 162(3):241-248.
26. Cardis E., Kesminiene A., Ivanov V., et al. Risk of thyroid cancer after exposure to 131I in childhood. J Natl Cancer Inst 2005, 97(10):724-732.
27. Tronko M.D., Howe G.R., Bogdanova T.I., et al. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: thyroid cancer in Ukraine detected during first screening. J Natl Cancer Inst 2006, 98(13):897-903.
28. Zablotska L.B., Ron E., Rozhko A.V., et al. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br J Cancer 2011, 104(4):181-187.
29. Brenner AV, Tronko MD, Hatch M, Bogdanova T, Oliynyk V, Lubin J. I-131 dose response for incident cancers in Ukraine related to the Chornobyl accident. Environ Health Perspect (in press).
30. Saad A.G., Kumar S., Ron E., et al. Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure. J Clin Endocrinol Metab 2006, 91(7):2672-2677.
31. Shibata Y., Yamashita S., Masyakin V.B., Panasyuk G.D., Nagataki S. 15 years after Chernobyl: new evidence of thyroid cancer. Lancet 2001, 358(9297):1965-1966.
32. Hatch M., Brenner A., Bogdanova T., et al. A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout. J Clin Endocrinol Metab 2009, 94(3):899-906.
33. Likhtarev I, Kovgan L, Chepurny M, et al. Estimation of the thyroid doses for Ukrainian children exposed in utero after the Chornobyl accident. Health Phys (in press).
34. Boice J.D., Engholm G., Kleinerman R.A., et al. Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat Res 1988, 116:3-55.
35. Carstensen J.M., Wingren G., Hatschek T., Fredriksson M., Noorlind-Brage H., Axelson O. Occupational risks of thyroid cancer: data from the Swedish Cancer Environment Register, 1961-1979. Am J Ind Med 1990, 18(5):535-540.
36. Richardson D.B. Exposure to ionizing radiation in adulthood and thyroid cancer incidence. Epidemiology 2009, 20(2):181-187.
37. Ivanov V.K., Gorski A.I., Maksioutov M.A., et al. Thyroid cancer incidence among adolescents and adults in the Bryansk region of Russia following the Chernobyl accident. Health Phys 2003, 84(1):46-60.
38. Prysyazhnyuk A.E., Gristchenko V., Fedorenko Z., et al. Twenty years after the Chernobyl accident: solid cancer incidence in various groups of the Ukrainian population. Radiat Environ Biophys 2007, 46:43-51.
39. Kenigsberg J., Buglova E. Health consequences. Chernobyl: catastrophe and consequences 2005, Springer, New York. J. Smith, N. Beresford (Eds.).
40. Ivanov V.K., Tsyb A.F., Petrov A.V., Maksioutov M.A., Shilyaeva T.P., Kochergina E.V. Thyroid cancer incidence among liquidators of the Chernobyl accident. Absence of dependence of radiation risks on external radiation dose. Radiat Environ Biophys 2002, 41(3):195-198.
41. Chernobyl NPP accident consequences cleaning up participants in Ukraine - health status epidemiologic study - main results 1996, European Commission, Brussels. A. Karaoglou, G. Desmet, G.N. Kelly, H.G. Menzel (Eds.).
42. Okeanov A.E., Ivanov V.C., Cardis E., et al. Study of cancer risk among liquidators, Report of EU experimental collaboration project 7: Epidemiologic investigations including dose assessment and dose reconstruction. 95/002 1995, International Agency for Research on Cancer, Lyon.
43. Cardis E., Anspaugh L., Ivanov V.K., et al. Estimated long term health effects of the Chernobyl accident. One decade after Chernobyl. Summing up the consequences of the accident 1996, International Atomic Energy Agency, Vienna, pp. 241-279.
44. Ivanov V.K., Chekin S.Y., Kashcheev V.V., Maksioutov M.A., Tumanov K.A. Risk of thyroid cancer among Chernobyl emergency workers of Russia. Radiat Environ Biophys 2008, 47(4):463-467.
45. Kesminiene A, Evrard AS, Ivanov VK, et al. Risk of thyroid cancer among Chernobyl liquidators. Radiat Res (submitted).
46. Williams E.D. Chernobyl and thyroid cancer. J Surg Oncol 2006, 94(8):670-677.
47. Shore R., Xue X.N. Comparative thyroid cancer risk of childhood and adult radiation exposure and estimation of lifetime risk. Radiation and thyroid cancer 1999, 491-498. World Scientific, Singapore. A. Karaoglou, E.D. Williams (Eds.).
48. Heidenreich W.F., Bogdanova T.I., Jacob P., Biryukov A.G., Tronko N.D. Age and time patterns in thyroid cancer after the Chernobyl accident in the Ukraine. Radiat Res 2000, 154(6):731-732.
49. Buglova E., Kenigsberg J., Sergeeva N.V. Cancer risk estimation in Belarussian children due to thyroid irradiation as a consequence of the Chernobyl nuclear accident. Health Phys 1996, 71:45-49.
50. Ron E. Thyroid cancer incidence among people living in areas contaminated by radiation from the Chernobyl accident. Health Phys 2007, 93(5):502-511.
51. Gembicki M., Stozharov A.N., Arinchin A.N., et al. Iodine deficiency in Belarusian children as a possible factor stimulating the irradiation of the thyroid gland during the Chernobyl catastrophe. Environ Health Perspect 1997, 105(Suppl. 6):1487-1490.
52. Robbins J., Dunn J.T., Bouville A., et al. Iodine nutrition and the risk from radioactive iodine: a workshop report in the Chernobyl long-term follow-up study. Thyroid 2001, 11(5):487-491.
53. Liu X.H., Chen G.G., Vlantis A.C., vanHasselt C.A. Iodine mediated mechanisms and thyroid carcinoma. Crit Rev Clin Lab Sci 2009, 46(5-6):302-318.
54. Folley J.H., Borges W., Yamawaki T. Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan. Am J Med 1952, 13:311-321.
55. Parkin D.M., Cardis E., Masuyer E., et al. Childhood leukaemia following the Chernobyl accident: the European Childhood Leukaemia-Lymphoma Incidence Study (ECLIS). Eur J Cancer 1993, 29A:87-95.
56. Parkin D.M., Clayton D., Black R.J., et al. Childhood leukaemia in Europe after Chernobyl: 5 year follow-up. Br J Cancer 1996, 73(8):1006-1012.
57. Ivanov E.P., Tolochko G., Lazarev V.S., Shuvaeva L. Child leukaemia after Chernobyl. Nature 1993, 365(6448):702.
58. Gapanovich V.N., Iaroshevich R.F., Shuvaeva L.P., Becker S.I., Nekolla E.A., Kellerer A.M. Childhood leukemia in Belarus before and after the Chernobyl accident: continued follow-up. Radiat Environ Biophys 2001, 40(4):259-267.
59. Ivanov V.K., Gorski A.I., Tsyb A.F., Khait S.E. Post-Chernobyl leukemia and thyroid cancer incidence in children and adolescents in Bryansk region: an evaluation of risks. Voprosy onkologii 2003, 49(4):445-449.
60. Ivanov V.K., Tsyb A.F. Medical radiological effects of the Chernobyl catastrophe on the population of Russia: estimation of radiation risks 2002, Meditsina, Moscow.
61. Noshchenko A.G., Zamostyan P.V., Bondar O.Y., Drozdova V.D. Radiation-induced leukemia risk among those aged 0-20 at the time of the Chernobyl accident: a case-control study in the Ukraine. Int J Cancer 2002, 99(4):609-618.
62. Davis S., Day R.W., Kopecky K.J., et al. Childhood leukaemia in Belarus, Russia, and Ukraine following the Chernobyl power station accident: results from an international collaborative population-based case-control study. Int J Epidemiol 2005, 35(2):386-396.
63. Noshchenko A.G., Bondar O.Y., Drozdova V.D. Radiation-induced leukemia among children age 0-5 years at the time of the Chernobyl accident. Int J Cancer 2010, 127(2):412-426.
64. Petridou E., Trichopoulos D., Dessypris N., et al. Infant leukaemia after in utero exposure to radiation from Chernobyl. Nature 1996, 382:352-353. [see comments].
65. Cardis E., Howe G., Ron E., et al. Cancer consequences of the Chernobyl accident: 20 years after. J Radiol Prot 2006, 26(2):127-140.
66. Kesminiene A., Evrard A.S., Ivanov V.K., et al. Risk of hematological malignancies among Chernobyl liquidators. Radiat Res 2008, 170(6):721-735.
67. Romanenko A.E., Finch S.C., Hatch M., et al. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: III. Radiation risks. Radiat Res 2008, 170:711-720.
68. Kryuchkov V., Chumak V., Maceika E., et al. RADRUE method for reconstruction of external gamma doses to Chernobyl liquidators in epidemiological studies. Health Phys 2009, 97(4):275-298.
69. Pukkala E., Kesminiene A., Poliakov S., et al. Breast cancer in Belarus and Ukraine after the Chernobyl accident. Int J Cancer 2006, 119(3):651-658.
70. Bogdanova N., Antomenkova N., Rogov Y., Karstens J., Hilemans P., Dörk T. High frequency and allele-specific differences of BRCA1 founder mutations in breast cancer and ovarian cancer patients from Belarus. Clin Genet 2010, 78(4):364-372.
71. Cardis E., Hall J., Tavtigian S.V. Identification of women with an increased risk of developing radiation-induced breast cancer. Breast Cancer Res 2007, 9(3):106.
72. Darby S., McGale P., Peto R., Granath F., Hall P., Ekbom A. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women. Br Med J 2003, 326(7383):256-257.
73. Hancock S.L., Tucker M.A., Hoppe R.T. Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA 1993, 270(16):1949-1955.
74. Preston D.L., Shimizu Y., Pierce D.A., Suyama A., Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 2003, 160(4):381-407.
75. Little M.P., Tawn E.J., Tzoulaki I., et al. Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms. Radiat Environ Biophys 2010, 49(2):139-153.
76. Buzunov V. Epidemiology of non-cancer effects of ionizing radiation. Bull Ukr Acad Med Sci 2006, 12(1):174-184.
77. Ivanov V.K., Maksioutov M.A., Chekin SYu, et al. The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers. Health Phys 2006, 90(3):199-207.
78. ICRP Age-dependent doses to members of the public from intakes of radionuclides: Part 1-Ingestion dose coefficients. ICRP Publication 56 1990, Pergamon Press, Oxford.
79. ICRP 1990 recommendations of the International Commission on Radiological Protection. Publication 60, Annals of the ICRP, 21 1991, Elsevier, Amsterdam.
80. Worgul B.V., Kundiyev Y.I., Sergiyenko N.M., et al. Cataracts among Chernobyl clean-up workers: implications regarding permissible eye exposures. Radiat Res 2007, 167(2):233-243.
81. ICRP Recommendations of the International Commission on Radiological Protection. ICRP Publication 60 1991, Pergamon Press, Oxford.
82. Drozdovitch V., Maceika E., Khrouch V., et al. Uncertainties in individual doses in a case control study of thyroid cancer after the Chernobyl accident. Radiat Prot Dosimetry 2007, 127(1-4):540-543.
83. Kopecky K.J., Stepanenko V., Rivkind N., et al. Childhood thyroid cancer, radiation dose from Chernobyl, and dose uncertainties in Bryansk Oblast, Russia: a population-based case-control study. Radiat Res 2006, 166(2):367-374.
84. Zablotska L.B., Bogdanova T.I., Ron E., et al. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000). Am J Epidemiol 2008, 167(3):305-312.
85. Williams D, Kesminiene A., Cardis E., Baverstock K. ARCH-Agenda for Research on Chernobyl Health. J Radiol Prot 2011, 31:151-153.