Radiation-induced leukemia among children aged 0-5 years at the time of the Chernobyl accident

International Journal of Cancer

Volumn 127, Issue 2, 2010, Pages 412-426

  Noshchenko, Andriy G ^a   Bondar, Oleksandra Y ^a   Drozdova, Vira D ^b  

^a NATIONAL UNIVERSITY OF KYIV MOHYLA ACADEMY   (Ukraine)

^b STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

Author keywords

Case control study; Chernobyl; Leukemia; Radiation; Ukraine

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; AGE; ARTICLE; CHERNOBYL ACCIDENT; CHILD; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; INFANT; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIOACTIVE CONTAMINATION; UKRAINE; ADOLESCENT; CASE CONTROL STUDY; COMPARATIVE STUDY; MYELOID LEUKEMIA; NUCLEAR ACCIDENT; PATHOLOGY; PRESCHOOL CHILD; RADIATION INDUCED NEOPLASM; RISK FACTOR; TIME;

ADOLESCENT; CASE-CONTROL STUDIES; CHERNOBYL NUCLEAR ACCIDENT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LEUKEMIA, MYELOID; MALE; NEOPLASMS, RADIATION-INDUCED; RADIOACTIVE HAZARD RELEASE; RISK FACTORS; TIME FACTORS; UKRAINE;

EID: 77953728864     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24834     Document Type: Article

References (49)

1. Cardis E, Krewski D, Mathieu B, Drozdovitch V, Darby SC, Gilbert ES, Akiba S, Benichou J, Ferlay J, Gandini S, Hill C, Howe G, et al. Estimation of the cancer burden in Europe from radioactive fallout from the Chernobyl accident. Int J Cancer 2006;119:1224-35.
2. Zamostian P, Moysich KB, Mahoney M, McCarthy P, Bondar A, Noshchenko A, Michalek A. Influence of various factors on individual radiation exposure from the Chernobyl disaster. Environ Health 2002;1:4.
3. United Nations Scientific Committee on the Effects of Atomic Radiation.Sources and effects of ionizing radiation: UNSCEAR 2000 Report to the General Assembly with Scientific Annexes.New York: United Nations, 2000.
4. Ichimaru M, Ishimaru T, Belsky JL. Incidence of leukemia in atomic bomb survivors, Hiroshima and Nagasaki 1959-1971 by radiation dose, years after exposure, age and type of leukemia. J Radiat Res 1978:19;262-82.
5. Preston DL, Kusumi SH, Tomonaga M, Izumi SH, Ron E, Kuramoto A, Kamada N, Dohy H, Matsui T, Nonaka H, Thompson D, Soda M, et al. Cancer incidence in Atomic bomb survivors. III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 1994;137:S68-S97.
6. Weiss HA, Darby SC, Doll R. Cancer mortality following X-ray treatment for ankylosing spondylitis. Int J Cancer 1994; 59:327-38. (Pubitemid 2150783)
7. Ivanov VK, Tsyb AF, Gorsky AI, Maksyutov MA, Rastopchin EM, Konogorov AP, Korelo AM, Biryukov AP, Matyash VA. Leukemia and thyroid cancer in emergency workers of the Chernobyl accident: estimation of radiation risks (1986-1995). Radiat Environ Biophys 1997; 36:9-16.
8. Ivanov VK, Tsyb AF, Konogorov AP, Rastopchin EM, Khait SE. Case-control analysis of leukemia among Chernobyl accident emergency workers residing in Russian Federation, 1986-1993. J Radiol Prot 1997;17:137-57.
9. Ivanov VK, Tsyb AF, Gorski AL, Maksyutov MA, Khait SE, Preston D, Shibata Y. Elevated leukemia rates in Chernobyl accident liquidators BMG, Rapid Responses, April 15, 2003 (available at www.bmj.com/cgi/eletters/319/7203/145/a) .
10. Bebeshko VG., Bruslova EM., Klimenko VI, Dyagil IS, Drozdova VD. Leukemias and lymphomas in Ukraine population exposed to chronic low dose irradiation. In: Low doses of ionizing radiation: biological effects and regulatory control. Contributed Papers International Conference, Seville, Spain, 17-21 November, 1997. IAEA-TECDOC-976, 337-8.
11. Ivanov EP, Parkin D, Tolochko G, Shuvaeva L, Ivanov V, Lazarev V, Iaroshkevich R. Hematological diseases in the Belarus Republic after the Chernobyl accident. Presented at the International Conference on Health Consequences of the Chernobyl Accident and other Radiological Accidents. Geneva: WHO, 1995.
12. Ivanov EP, Parkin D, Tolochko GV, Shuvaeva L, Becker S, Nekolla E, Keller AM. Childhood leukemia in Belarus before and after the Chernobyl accident. Radiat Environ Biophys 1996; 35:75-80. (Pubitemid 26190837)
13. WHO. Health consequences of the Chernobyl accident. Results of the IPHECA pilot projects and related national programs. Geneva: WHO, 1996
14. Parkin DM, Cardis E, Masuyer E, Friedl HP, Hansluwka H, Bobev D, Ivanov E, Sinnaeve J, Agustin J, Plesko J, Storm HH, Rahu M, et al. Childhood leukemia following the Chernobyl accident: the European Childhood Leukemia-Lymphoma Incidence Study (ECLIS). Eur J Cancer 1993;29A:87-95.
15. 137Cs fallout after the Chernobyl accident. Health Phys 1996;71:947-50.
16. Petridou E, Trichopoulos D, Dessypris N, Flytzani V, Haidas V, Kalmani M, Koliouskas D, Kosmidis H, Piperopoulou F, Tzortzatou F. Infant leukemia after in utero exposure to radiation from Chernobyl. Nature 1996;382:352-3. (Pubitemid 26260461)
17. Hjalmars U, Kulldorff M, Gustafson G. Risk of acute childhood leukemia in Sweden after the Chernobyl reactor accident. BMJ 1994;109:154-7. (Pubitemid 24216478)
18. Prisyazhniuk A, Gristchenko V, Zakordonets V. The time trends of cancer incidence in the most contaminated regions of the Ukraine before and after the Chernobyl accident. Radiat Environ Biophys 1995;34:3-6.
19. Drozdova V, Moroz G, Kireyeva S. Descriptive epidemiology of leukemias in children in the regions of Ukraine caused by Chernobyl A.P.S. accident [In Russian]. J Exp Oncol 1996;18:128-31. (Pubitemid 126779487)
20. Noshchenko AG, Moysich KB, Bondar A, Zamostyan PV, Drosdova VD, Michalek AM. Patterns of acute leukemia occurrence among children in the Chernobyl region. Int J Epidemiol 2001;30:125-9. (Pubitemid 32203800)
21. Shimizu Y, Schull WJ, Kato H. Cancer risk among atomic bomb survivors. The RERF Life Span Study. JAMA 1990;264:601-4.
22. Stevens W, Thomas DC, Lyon JL, Till JE, Kerber RA, Simon SL, et al. Leukemia in Utah and radioactive fallout from the Nevada test site. JAMA 1990;264: 585-91.
23. Noshchenko A, Zamostyan PV, Bondar O, Drozdova V. Radiation-induced leukemia risk among those aged 0-20 at the time of the Chernobyl accident: a case-control study in the Ukraine. Int J Cancer 2002;99: 609-18 (Pubitemid 34461617)
24. Davis S, Day RW, Kopecky KJ, Mahoney MC, McCarthy PL, Michalek AM, Moysich KB, Onstad LE, Stepanenko VF, Voillequé P, Chegerova T, Falkner K, et al. Childhood leukaemia in Belarus. Russia, and. Ukraine following the. Chernobyl power station accident: results from an international collaborative population-based case-control study. Int J Epidemiol 2006;35:386-96.
25. Howe GR. Leukemia following the Chernobyl accident. Health Phys 2007;23:512-15.
26. Kesminiene A, Cardis E. Cancer epidemiology after the Chernobyl accident. Bull Cancer 2007;94:423-30.
27. Hashibe M, Ritz B, Le A, Li G, Sankaranarayanan R, Zhang Z. Radiotherapy for oral cancer as a risk factor for second primary cancers. Cancer Lett 2005;220:185-95. (Pubitemid 40568776)
28. Chuang SC, Hashibe M, Yu GP, Le AD, Cao W, Hurwitz EL, Rao JY, Neugut AI, Zhang ZF. Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers. Cancer Lett 2006;238:42-52.
29. McCarthy PL, Paltiel O, Maslova E, Kulikov S, Hahn T, Kopecky K, Drozdova V, Shmatina N, Tichonova L, Van Hoff J, Gavrilova I, Weinstein H. Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine. Leuk Res 2004;28:1273-80.
30. Balonov M, Jacob P, Likhtariov I, Minenko V. Pathways, levels and trends of population exposure after the Chernobyl accident. The radiological consequences of the Chernobyl accident. In Proceedings of the First International Conference Minsk, Belarus, 18-22 March. Luxemburg: Office for the Official Publications of the European Communities, 1996. 235-51.
31. Ten years after the accident at Chernobyl NPP Ukraine National Report. Ministry of Chernobyl of Ukraine. Kiev. 1996 (in Russian).
32. 137Cs after the. Chernobyl accident. Report 1. General model: ingestion doses and countermeasure effectiveness for the adults of Rovno Oblast of Ukraine. Health Phys 1996;70: 297-317.
33. Likhtariov I, Kovgan L, Novak D, Vavilov S, Jacob P, Herwig G. Paretzke H. Effective doses due to external irradiation from the Chernobyl accident for different population groups of Ukraine Health Phys 1996;70: 87-98.
34. Likhtariov I, Kovgan L, Vavilov S, Perevoznikov O, Litvinets L, Anspaugh L, Jacob P, Pröhl G. Internal exposure from the ingestion of foods contaminated by Cs after the Chernobyl accident. Report 2: ingestion doses of the rural population of Ukraine up to 12 years after the accident (1986-1997). Health Phys 2000;79: 341-58.
35. Likhtariov I, Kovgan L, Los I, Berkovsky V, Boiko Z, Vavilov S, Ivanova O, Panchuk O, Pelukh A, Perevoznikov O, Pozhyvilova O. Retrospective-prognosis doses of population exposure and general 1997 dosimetry passportisation for the settlements of Ukraine, affected by radioactive contamination as a result of the accident at ChNPP. Generalized data for 1986-1997 yy Issue 7 [in Ukrainian] Kiev: RCRM SU, 1996. 155 p
36. Likhtariov I, Kovgan L, Berkovsky V, Tabachny L. Instructive methodical regulation. Reconstruction and prognosis of exposure doses for population residing at the territories of Ukraine affected by radioactive contamination as a result of the accident at ChNPP. (Methodic-97). [in Ukrainian] Kyiv: RCRM AMSU, 1998. 47 p.
37. Thompson KM, Burmaster DE, Crouch EA. Monte Carlo techniques for quantitative uncertainty analysis in public health risk assessments. Risk Anal 1992;12: 53-63.
38. Kopylev L, Chen Ch, White P. Towards quantitative uncertainty assessment for cancer risk: central estimates and probability distribution of risk in dose-response modeling. Regul Toxicol Pharmacol 2007;49:203-7.
39. Glantz SA. Primer of biostatistics, 6th edn. New-York: The McGraw-Hill Comp Inc, 2005.
40. Breslow NE, Day NE. Statistical methods in cancer research, vol. I: The analysis of case-control studies. Lyon: IARC, 1980.
41. Hennekens CH, Buring SD. Epidemiology in medicine. Philadelphia: Lippincott Williams & Wlkins, 1987.
42. US National Research Council. Health risks from exposure to low levels of ionizing radiation. BEIR, VII Report, phase II. Washington, DC: National Academy of Science, 2005.
43. Nakamura N. A hypothesis: radiation-related leukemia is mainly attributable to the small number of people who carry pre-existing clonally expanded preleukemic cells. Radiat Res 2005;163: 258-65.
44. Mori H, Colman S, Xiao Z, Ford A, Healy L, Donaldson C, Hows J, Navarrete C, Greaves M. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 2002; 99:8242-47.
45. Infante-Rivard C. Diagnostic X rays. DNA repair genes and childhood acute lymphoblastic leukemia. Health Phys 2003; 85:60-4.
46. Jawad M, Seedhouse C, Russel N, Plumb M. Polymorphism in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia. Blood 2006;108:3916-18.
47. Podvin D, Kuehn C, Mueller B, Williams M. Maternal and birth characteristics in relation to childhood leukaemia. Paediatr Perinatal Epidemiol 2006;20:312-22.
48. Rossig C, Heribert J. Aetiology of childhood acute leukaemias: current status of knowledge. Radiat Prot Dosimetry 2008; 132:114-18.
49. Ross J, Potter J, Reaman G, Pendergrass T, Robinson L. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the children's cancer group. Cancer Cause Cont 1996;7:581-90.