Are breast conservation and mastectomy equally effective in the treatment of young women with early breast cancer? Long-term results of a population-based cohort of 1,451 patients aged ≤40 years

Breast Cancer Research and Treatment

Volumn 127, Issue 1, 2011, Pages 207-215

  Van Der Sangen, Maurice J C ^a   Van De Wiel, Fenneke M M ^b   Poortmans, Philip M P ^c   Tjan Heijnen, Vivianne C G ^d   Nieuwenhuijzen, Grard A P ^a   Roumen, Rudi M H ^e   Ernst, Miranda F ^f   Tutein Nolthenius Puylaert, M Cathelijne B J E ^g   Voogd, Adri C ^d,h  

^a CATHARINA HOSPITAL   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c DR BERNARD VERBEETEN INSTITUTE   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e MÁXIMA MEDICAL CENTER   (Netherlands)

^f JEROEN BOSCH HOSPITAL   (Netherlands)

^g ELKERLIEK HOSPITAL   (Netherlands)

^h Erasmus University Rotterdam and Eindhoven Cancer Registry   (Netherlands)

Author keywords

Breast carcinoma; Breast conservation; Local control; Mastectomy; Prognosis; Survival; Systemic treatment

Indexed keywords

CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE;

ADULT; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CONTROL; CANCER STAGING; COHORT ANALYSIS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; EARLY CANCER; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INTERMETHOD COMPARISON; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MASTECTOMY; NETHERLANDS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PARTIAL MASTECTOMY; POPULATION RESEARCH; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT CANCER; RISK ASSESSMENT;

ADULT; AGE FACTORS; BREAST NEOPLASMS; COHORT STUDIES; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MASTECTOMY; MASTECTOMY, SEGMENTAL; NEOPLASM STAGING; RECURRENCE; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 79954896036     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1110-x     Document Type: Article

References (40)

1. U Veronesi N Cascinelli L Mariani M Grecco R Saccozzi A Luini M Aguilar E Marubini 2002 Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer N Engl J Med 347 16 1227 1232 12393819 10.1056/NEJMoa020989 (Pubitemid 35176241)
2. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong J-H, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16)
3. JA Van Dongen AC Voogd IS Fentiman C Legrand RJ Sylvester D Tong E Van der Schueren PA Helle K Van Zijl H Bartelink 2000 Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial J Natl Cancer Inst 92 14 1143 1150 10904087 10.1093/jnci/92.14.1143
4. JA Jacobson DN Danforh KH Cowan T D'Angelo SM Steinberg L Pierce ME Lippman AS Lichter E Glatstein P Okunieff 1995 Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer N Engl J Med 332 14 907 911 7877647 10.1056/NEJM199504063321402 1:STN:280:DyaK2M7otlSqsw%3D%3D
5. Blichert-Toft M, Rose C, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, Mouridsen HT (1992) Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish breast cancer cooperative group. J Natl Cancer Inst Monogr (11):19-25
6. AC Voogd M Nielsen JL Peterse M Blichert-Toft H Bartelink M Overgaard G Van Tienhoven K West Andersen RJ Sylvester JA Van Dongen 2001 Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results for two large European randomized trials J Clin Oncol 19 6 1688 1697 11250998 1:STN:280:DC%2BD3M3gsl2nsg%3D%3D (Pubitemid 32230869)
7. GH De Bock JA van der Hage H Putter J Bonnema H Bartelink CJ Van de Velde 2006 Isolated loco-regional recurrence of breast cancer is more common in young patients and following breast conserving therapy: long-term results of European organisation for research and treatment of cancer studies Eur J Cancer 42 3 351 356 16314086 10.1016/j.ejca.2005.10.006 (Pubitemid 43132890)
8. C Vrieling A Fourquet WJ Hoogenraad JC Horiot JJ Jager S Bing Oei HL Peterse M Pierart PM Poortmans H Struikmans W Van den Bogaert H Bartelink 2003 Can patient-, treatment- and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients? Eur J Cancer 39 7 932 944 12706362 10.1016/S0959-8049(03)00123-0 1:STN:280:DC%2BD3s7osl2mtA%3D%3D (Pubitemid 36428625)
9. PHM Elkhuizen MJ Van de Vijver J Hermans HM Zonderland CJ Van de Velde J-WH Leer 1998 Local recurrence after breast-conserving therapy for invasive breast cancer: high incidence in young patients and association with poor survival Int J Radiat Oncol Biol Phys 40 4 859 867 9531371 10.1016/S0360- 3016(97)00917-6 1:STN:280:DyaK1c7ovFymuw%3D%3D (Pubitemid 28150804)
10. HA Jones N Antonini AA Hart JL Peterse JC Horiot F Collin PM Poortmans SB Oei L Collette H Struikmans WF Van den Bogaert A Fourquet JJ Jager DA Schinagl CC Wárlám-Rodenhuis H Bartelink 2009 Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial J Clin Oncol 27 30 4939 4947 19720914 10.1200/JCO.2008.21.5764
11. JJ Jobsen J Van der Palen F Ong JH Meerwaldt 2003 The value of a positive margin for invasive carcinoma in breast-conservative treatment in relation to local recurrence is limited to young women only Int J Radiat Oncol Biol Phys 57 3 724 731 14529777 10.1016/S0360-3016(03)00644-8 (Pubitemid 37194298)
12. R Arriagada MG Lê J-M Guinebretière A Dunant F Rochard T Tursz 2003 Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients Ann Oncol 14 11 1617 1622 14581268 10.1093/annonc/mdg452 1:STN:280:DC%2BD3srgtlWqsg%3D%3D (Pubitemid 37455809)
13. M Van der Leest L Evers MJC Van der Sangen PM Poortmans LV Van de Poll-Franse AJ Vulto GAP Nieuwenhuijzen SJ Brenninkmeijer G Creemers AC Voogd 2007 The safety of breast-conserving therapy in patients with breast cancer aged ≤40 years Cancer 109 10 1957 1964 17394192 10.1002/cncr.22639 (Pubitemid 46744188)
14. EJR Lammers P Huibers MJC Van der Sangen LV Van de Poll-Franse PM Poortmans MF Ernst BMD Lemaire CMEM Meijs HKS Nuytinck AC Voogd 2010 Factors contributing to improved local control after mastectomy in patients with breast cancer aged 40 years or younger Breast 19 1 44 49 19913419 10.1016/j.breast. 2009.10.009
15. G Coulombe S Tyldesley C Speers C Paltiel C Aquino-Parsons V Bernstein P Truong M Keyes IA Olivotto 2007 Is mastectomy superior to breast-conserving treatment for young women? Int J Radiat Oncol Biol Phys 67 5 1282 1290 17275207 10.1016/j.ijrobp.2006.11.032 (Pubitemid 46467166)
16. BM Beadle WA Woodward SL Tucker ED Outlaw PK Allen JL Oh EA Strom GH Perkins W Tereffe T Yu F Meric-Bernstam JK Litton TA Buchholz 2009 Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach Int J Radiat Oncol Biol Phys 73 3 734 744 18707822 10.1016/j.ijrobp. 2008.04.078
17. N Kroman H Holtveg J Wohlfart M-B Jensen HT Mouridsen M Blichert-Toft M Melbye 2004 Effect of breast-conserving therapy versus radical mastectomy on prognosis for young women with breast carcinoma Cancer 100 4 688 693 14770422 10.1002/cncr.20022 (Pubitemid 38176844)
18. M Bontenbal JW Nortier LV Beex P Bakker PS Hupperets MA Nooij H Van Veelen G Vreugdenhil DJ Richel GH Bijham 2000 Adjuvant systemic therapy for patients with resectable breast cancer: guideline from the Dutch National Breast Cancer Platform and the Dutch Society for Medical Oncology Ned Tijdschr Geneeskd 144 21 984 989 10858788 1:STN:280:DC%2BD3czhs1GqsA%3D%3D (Pubitemid 30322179)
19. A Goldhirsch JH Glick RD Gelber HJ Senn 1998 Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer J Natl Cancer Inst 90 21 1601 1608 9811309 10.1093/jnci/90.21.1601 1:STN:280: DyaK1M%2FislCnug%3D%3D (Pubitemid 28523434)
20. A Goldhirsch JH Glick RD Gelber AS Coates HJ Senn 2001 Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh international conference on adjuvant therapy of primary breast cancer J Clin Oncol 19 18 3817 3827 11559719 1:STN:280:DC%2BD3Mrht1Slsw%3D%3D (Pubitemid 32880060)
21. P Zhou S Gautam A Recht 2007 Factors affecting outcome for young women with early stage invasive breast cancer treated with breast-conserving therapy Breast Cancer Res Treat 101 1 51 57 16821084 10.1007/s10549-006-9268-y 1:CAS:528:DC%2BD2sXisVymsg%3D%3D (Pubitemid 47555329)
22. B Kreike AMA Hart T Van de Velde J Borger H Peterse E Rutgers H Bartelink MJ Van de Vijver 2008 Continuing risk of ipsilateral breast relapse after breast-conserving therapy at long-term follow-up Int J Radiat Oncol Biol Phys 71 4 1014 1021 18234444 10.1016/j.ijrobp.2007.11.029
23. M Clarke R Collins S Darby C Davies P Elphinstone E Evans J Godwin R Gray C Hicks S James E MacKinnon P McGale T McHugh R Peto C Taylor Y Wang 2005 Effects of radiotherapy and differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials Lancet 366 9503 2087 2106 16360786 1:STN:280: DC%2BD2MnnsVSitA%3D%3D (Pubitemid 41797643)
24. RS Punglia M Morrow EP Winer JR Harris 2007 Local therapy and survival in breast cancer N Engl J Med 356 23 2399 2405 17554121 10.1056/NEJMra065241 1:CAS:528:DC%2BD2sXmt1Wntrg%3D (Pubitemid 46887273)
25. AC Voogd OJ Repelaer van Driel RMH Roumen MA Crommelin MWPM Van Beek JWW Coebergh 1997 Changing attitudes towards breast-conserving treatment of early breast cancer in the south-eastern Netherlands: results of a survey among surgeons and a registry-based analysis of patterns of care Eur J Surg Oncol 23 2 134 138 9158187 10.1016/S0748-7983(97)80006-6 1:STN:280:DyaK2szgtFyjuw%3D%3D (Pubitemid 27223006)
26. TA Buchholz SL Tucker J Erwin D Mathur EA Strom MD McNeese GN Hortobagyi M Cristofanilli FJ Esteva L Newman ES Singletary AU Buzdar KK Hunt 2001 Impact of systemic treatment on local control for patients with lymph node-negative breast cancer treated with breast-conservation therapy J Clin Oncol 19 8 2240 2246 11304777 1:CAS:528:DC%2BD3MXjsFeru7c%3D (Pubitemid 32372325)
27. N Kroman M-B Jensen J Wohlfart HT Mouridsen PK Andersen M Melbye 2000 Factors influencing the effect of age on prognosis in breast cancer: population based study BMJ 320 7233 474 478 10678859 10.1136/bmj.320.7233.474 1:STN:280:DC%2BD3c7ktlKitw%3D%3D (Pubitemid 30173116)
28. CC Park M Mitsumori A Nixon A Recht J Connoly R Gelman B Silver S Hetelekidis A Abner JR Harris SJ Schnitt 2000 Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: Influence of margin status and systemic therapy on local recurrence J Clin Oncol 18 8 1668 1675 10764427 1:STN:280:DC%2BD3c3islOquw%3D%3D (Pubitemid 30220545)
29. S McGrath J Antonucci N Goldstein M Wallace C Mitchell I Grills S Jolly L Kestin F Vicini 2010 Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation Am J Clin Oncol 33 1 17 22 19636236 10.1097/COC.0b013e31819cccc3 1:CAS:528:DC%2BC3cXhs1ygtro%3D
30. BL Schlechter Q Yang PS Larson A Golubeva RA Blanchard A de las Morenas CL Rosenberg 2004 Quantitative DNA fingerprinting may distinguish new primary breast cancer from disease recurrence J Clin Oncol 22 10 1830 1838 15143075 10.1200/JCO.2004.05.123 1:CAS:528:DC%2BD2cXptlCksr8%3D (Pubitemid 41095173)
31. CK Anders DS Hsu G Broadwater CR Acharya JA Foekens Y Zhang Y Wang PK Marcom JR Marks PG Febbo JR Nevins A Potti KL Blackwell 2008 Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shares patterns of gene expression J Clin Oncol 26 20 3324 3330 18612148 10.1200/JCO.2007.14.2471
32. B Kreike H Halfwerk N Armstrong P Bult JA Foekens SC Veltkamp DSA Nuyten H Bartelink MJ Van de Vijver 2009 Local recurrence after breast-conserving therapy in relation to gene expression patterns in a large series of patients Clin Cancer Res 15 12 4181 4190 19470741 10.1158/1078-0432.CCR-08-2644 1:CAS:528:DC%2BD1MXntlOisbs%3D
33. DL Ellsworth RE Ellsworth B Love B Deyarmin SM Lubert V Mittal CD Shriver 2004 Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas Breast Cancer Res Treat 88 2 131 139 15564796 10.1007/s10549-004-1424-7 1:CAS:528:DC%2BD2cXhtVWgtbzJ (Pubitemid 39575570)
34. PS Yan C Venkataramu A Ibrahim JC Liu RZ Shen NM Diaz B Centeno F Weber YW Leu CL Shapiro C Eng TJ Yeatman THM Huang 2006 Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue Clin Cancer Res 12 22 6626 6636 17121881 10.1158/1078-0432.CCR-06-0467 1:CAS:528: DC%2BD28Xht1elsL7F (Pubitemid 44876830)
35. S De Sanjosé M Léoné V Bérez A Izquierdo R Font JM Brunet T Louat L Vilardell J Borras P Viladiu FX Bosch GM Lenoir OM Sinilnikova 2003 Prevalence of BRCA1 and BRCA2 germline mutations in young breast cancer patients: a population based study Int J Cancer 106 4 588 593 12845657 10.1002/ijc.11271 (Pubitemid 36966218)
36. LJ Pierce AM Levin TR Rebbeck MA Ben-David E Friedman LJ Solin EE Harris DK Gaffney BG Haffty LA Dawson SA Narod IA Olivotto A Eisen TJ Whelan OI Olopade C Isaacs SD Merajver JS Wong JE Garber BL Weber 2006 Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer J Clin Oncol 24 16 2437 2443 16636335 10.1200/JCO.2005.02.7888 (Pubitemid 46630619)
37. BG Haffty E Harrold AJ Khan P Pathare TE Smith BC Turner PM Glazer B Ward D Carter E Matloff AE Bale M Alvarez-Franco 2002 Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status Lancet 359 9316 1471 1477 11988246 10.1016/S0140-6736(02)08434-9 (Pubitemid 34457765)
38. TE Alpert BG Haffty 2004 Conservative management of breast cancer in BRCA1/2 mutation carriers Clin Breast Cancer 5 1 37 42 15140283 10.3816/CBC.2004.n.008 (Pubitemid 38821189)
39. M Kyndi FB Sorensen H Knudsen M Overgaard H Melgaard Nielsen M Overgaard 2008 Estrogen receptor, progesterone receptor, HER-2, and response to mastectomy radiotherapy in high-risk breast cancer: The Danish Breast Cancer Cooperative Group J Clin Oncol 26 9 1419 1426 18285604 10.1200/JCO.2007.14.5565 1:CAS:528:DC%2BD1cXkslKqs7c%3D
40. EH Romond EA Perez J Bryant VJ Suman CE Geyer NE Davidson E Tan-Chiu S Martino S Paik PA Kaufman SM Swain TM Pisansky L Fehrenbacher LA Kutteh VG Vogel DW Visscher G Yothers RB Jenkins AM Brown SR Dakhil EP Mamounas WL Lingle PM Klein JN Ingle N Wolmark 2005 Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer N Engl J Med 353 16 1673 1684 16236738 10.1056/NEJMoa052122 1:CAS:528:DC%2BD2MXhtFansr3F (Pubitemid 41464706)