Memory T cells migrate to and reject vascularized cardiac allografts independent of the chemokine receptor CXCR3

Transplantation

Volumn 91, Issue 8, 2011, Pages 827-832

  Oberbarnscheidt, Martin H ^a   Walch, Jeffrey M ^a   Li, Qi ^a   Williams, Amanda L ^a   Walters, John T ^a   Hoffman, Rosemary A ^a   Demetris, Anthony J ^a   Gerard, Craig ^b   Camirand, Geoffrey ^a   Lakkis, Fadi G ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Chemokine receptor; Rejection; T lymphocyte; Transplantation

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3;

ANIMAL EXPERIMENT; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FLOW CYTOMETRY; GRAFT SURVIVAL; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLENECTOMY; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; CELL ADHESION MOLECULES; CELL MOVEMENT; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CCR5; RECEPTORS, CXCR3; SPLENECTOMY; T-LYMPHOCYTES; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 79954867272     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31820f0856     Document Type: Article

References (19)

1. Macedo C, Orkis EA, Popescu I, et al. Contribution of naive and memory T-cell populations to the human alloimmune response. Am J Transplant 2009; 9: 2057.
2. Heeger PS, Greenspan NS, Kuhlenschmidt S, et al. Pretransplant frequency of donor-specific, IFN-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 1999; 163: 2267.
3. Chalasani G, Dai Z, Konieczny BT, et al. Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs. Proc Natl Acad Sci USA 2002; 99: 6175.
4. Obhrai JS, Oberbarnscheidt MH, Hand TW, et al. Effector T cell differentiation and memory T cell maintenance outside secondary lymphoid organs. J Immunol 2006; 176: 4051.
5. Schenk AD, Nozaki T, Rabant M, et al. Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients. Am J Transplant 2008; 8: 1652.
6. Mohan K, Issekutz TB. Blockade of chemokine receptor CXCR3 inhibits T cell recruitment to inflamed joints and decreases the severity of adjuvant arthritis. J Immunol 2007; 179: 8463.
7. Nakanishi Y, Lu B, Gerard C, et al. CD8(-) T lymphocyte mobilization to virus-infected tissue requires CD4(-) T-cell help. Nature 2009; 462: 510.
8. Chalasani G, Li Q, Konieczny BT, et al. The allograft defines the type of rejection (acute versus chronic) in the face of an established effector immune response. J Immunol 2004; 172: 7813.
9. Loetscher M, Gerber B, Loetscher P, et al. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated Tlymphocytes. J Exp Med 1996; 184: 963.
10. Halloran PF, Fairchild RL. The puzzling role of CXCR3 and its ligands in organ allograft rejection. Am J Transplant 2008; 8: 1578.
11. Hancock WW, Lu B, Gao W, et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000; 192: 1515.
12. Kwun J, Hu H, Schadde E, et al. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3 /mouse recipients. J Immunol 2007; 179: 8016.
13. Zerwes HG, Li J, Kovarik J, et al. The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats. Am J Transplant 2008; 8: 1604.
14. Kwun J, Hazinedaroglu SM, Schadde E, et al. Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3 /mouse recipients. Am J Transplant 2008; 8: 1593.
15. Haskova Z, Izawa A, Contreras AG, et al. Organ-specific differences in the function of MCP-1 and CXCR3 during cardiac and skin allograft rejection. Transplantation 2007; 83: 1595.
16. Gao W, Faia K, Csizmadia V, et al. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 2001; 72: 1199.
17. Amano H, Bickerstaff A, Orosz CG, et al. Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J Immunol 2005; 174: 6499.
18. Hancock WW, Gao W, Faia KL, et al. Chemokines and their receptors in allograft rejection. Curr Opin Immunol 2000; 12: 511.
19. Carvalho-Pinto C, Garcia MI, Gomez L, et al. Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice. Eur J Immunol 2004; 34: 548.