Effect of angiotensin AT1 receptor blockade on sympathetic responses to handgrip in healthy men

American Journal of Hypertension

Volumn 24, Issue 5, 2011, Pages 537-543

  McGowan, Cheri L ^a   Notarius, Catherine F ^a   McReynolds, Andrew ^a   Morris, Beverley L ^a   Kimmerly, Derek S ^a   Picton, Peter E ^a   Floras, John S ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

adenosine; blood pressure; hypertension; losartan; metaboreflex; muscle sympathetic nerve activity

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; LOSARTAN;

ADULT; ANGIOTENSIN BLOOD LEVEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HAND GRIP; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; ISOMETRIC EXERCISE; ISOTONIC EXERCISE; MALE; MAXIMUM VOLUNTARY CONTRACTION; MUSCLE EXCITATION; MUSCLE ISCHEMIA; MUSCLE SYMPATHETIC NERVE ACTIVITY; NORMAL HUMAN; PARAMETER; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REST; SKELETAL MUSCLE; SYMPATHETIC FUNCTION; SYMPATHETIC REFLEX; ADRENERGIC SYSTEM; BLOOD PRESSURE; CLINICAL TRIAL; COLD; CONTROLLED CLINICAL TRIAL; EXERCISE; INNERVATION; PHYSIOLOGY; REFLEX;

ADULT; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BLOOD PRESSURE; COLD TEMPERATURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE; HEART RATE; HUMANS; LOSARTAN; MALE; MUSCLE, SKELETAL; REFLEX; SYMPATHETIC NERVOUS SYSTEM;

EID: 79954756900     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2011.14     Document Type: Article

References (26)

1. Reid IA. Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure. Am J Physiol 1992; 262:E763-E778.
2. Rongen GA, Brooks SC, Ando S, Abramson BL, Floras JS. Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine J Clin Invest 1998; 101:769-776. (Pubitemid 28096073)
3. Dampney RA, Fontes MA, Hirooka Y, Horiuchi J, Potts PD, Tagawa T. Role of angiotensin II receptors in the regulation of vasomotor neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol 2002; 29:467-472. (Pubitemid 34535371)
4. Heusser K, Vitkovsky J, Raasch W, Schmieder RE, Schobel HP. Elevation of sympathetic activity by eprosartan in young male subjects. Am J Hypertens 2003; 16:658-664. (Pubitemid 36900589)
5. Rongen GA, Brooks SC, Ando S, Dajani HR, Abramson BL, Floras JS. Neural and hypotensive effects of angiotensin II receptor blockade. Hypertension 1998; 31:378-383.
6. Krum H, Lambert E, Windebank E, Campbell DJ, Esler M. Effect of angiotensin receptor blockade on autonomic nervous system function in patients with essential hypertension. Am J Physiol Heart Circ Physiol 2006; 290:H1706-H1712.
7. Struck J, Muck P, Trübger D, Handrock R, Weidinger G, Dendorfer A, Dodt C. Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects. J Hypertens 2002; 20:1143-1149 (Pubitemid 34913633)
8. Hellsten Y, Maclean D, Rådegran G, Saltin B, Bangsbo J. Adenosine concentrations n the interstitium of resting and contracting human skeletal muscle. Circulation 1998; 98:6-8. (Pubitemid 28312071)
9. Mortensen SP, Nyberg M, Thaning P, Saltin B, Hellsten Y Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. Hypertension 2009; 53:993-999.
10. Costa F, Biaggioni I. Role of adenosine in the sympathetic activation produced by sometric exercise in humans J Clin Invest 1994; 93:1654-1660. (Pubitemid 24116405)
11. Costa F, Biaggioni I. Adenosine activates afferent fibers in the forearm, producing sympathetic stimulation in humans J Pharmacol Exp Ther 1993; 267:1369-1374. (Pubitemid 24068709)
12. Song KF, Zhuo JL, Mendelsohn FA. Access of peripherally administered DuP 753 to rat brain angiotensin II receptors. Br J Pharmacol 1991; 104:771-772.
13. Fagius J, Karhuvaara S. Sympathetic activity and blood pressure increases with bladder distension in humans. Hypertension 1989; 14:511-517. (Pubitemid 19270516)
14. Ando S, Dajani HR, Floras JS. Frequency domain characteristics of muscle sympathetic nerve activity in heart failure and healthy humans. Am J Physiol 1997; 273:R205-R212.
15. Notarius CF, Atchison DJ, Floras JS. Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise. Am J Physiol Heart Circ Physiol 2001; 280:H969-H976.
16. Spaak J, Merlocco AC, Soleas GJ, Tomlinson G, Morris BL, Picton P Notarius CF, Chan CT, Floras JS. Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. Am J Physiol Heart Circ Physiol 2008; 294:H605-H612. (Pubitemid 351253271)
17. Scherrer U, Pryor SL, Bertocci LA, Victor RG. Arterial baroreflex buffering of sympathetic activation during exercise-induced elevations in arterial pressure J Clin Invest 1990; 86:1855-1861.
18. Ogoh S, Fisher JP, Young CN, Raven PB, Fadel PJ. Transfer function characteristics of the neural and peripheral arterial baroreflex arcs at rest and during postexercise muscle ischemia in humans. Am J Physiol Heart Circ Physiol 2009; 296:H1416-H1424.
19. Song K, Allen AM, Paxinos G, Mendelsohn FA. Mapping of angiotensin II receptor subtype heterogeneity in rat brain. J Comp Neurol 1992; 316:467-484.
20. Gross V, Plehm R, Tank J, Jordan J, Diedrich A, Obst M, Luft FC Heart rate variability and baroreflex function in AT2 receptor-disrupted mice. Hypertension 2002; 40:207-213. (Pubitemid 34840100)
21. Silva AQ, Santos RA, Fontes MA. Blockade of endogenous angiotensin-(1-7) n the hypothalamic paraventricular nucleus reduces renal sympathetic tone Hypertension 2005; 46:341-348. (Pubitemid 41099167)
22. Cui J, McQuillan P, Momen A, Blaha C, Moradkhan R, Mascarenhas V, Hogeman C, Krishnan A, Sinoway LI. The role of the cyclooxygenase products in evoking sympathetic activation in exercise. Am J Physiol Heart Circ Physiol 2007; 293:H1861-H1868. (Pubitemid 47367236)
23. Houssière A, Najem B, Cuylits N, Cuypers S, Naeije R, van de Borne P. Hyperoxia enhances metaboreflex sensitivity during static exercise in humans. Am J Physiol Heart Circ Physiol 2006; 291:H210-H215.
24. Notarius CF, Atchison DJ, Rongen GA, Floras JS. Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol Heart Circ Physiol 2001; 281:H1312-H1318.
25. Zhuo J, Song K, Abdelrahman A, Mendelsohn FA. Blockade by intravenous osartan of AT1 angiotensin II receptors in rat brain, kidney and adrenals demonstrated by in vitro autoradiography Clin Exp Pharmacol Physiol 1994; 21:557-567. (Pubitemid 24255682)
26. Webb AJ, Fischer U, Mehta Z, Rothwell PM. Effects of antihypertensive- drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 2010; 375:906-915.