The role of the cyclooxygenase products in evoking sympathetic activation in exercise

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 3, 2007, Pages

  Cui, Jian ^a   McQuillan, Patrick ^a   Momen, Afsana ^a   Blaha, Cheryl ^a   Moradkhan, Raman ^a   Mascarenhas, Vernon ^a   Hogeman, Cynthia ^a   Krishnan, Anandi ^a   Sinoway, Lawrence I ^a,b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Exercise; Nervous system; Prostaglandins; Regional blood flow; Sympathetic

Indexed keywords

KETOROLAC TROMETAMOL; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONDUCTANCE; CONTROLLED STUDY; DRUG MECHANISM; EVOKED RESPONSE; EXERCISE; FEMALE; FOREARM; HAND GRIP; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE FATIGUE; MUSCLE ISCHEMIA; NERVE CONDUCTION; NEUROGRAPHY; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SYMPATHETIC NERVE; SYMPATHETIC TONE;

ADULT; BLOOD PRESSURE; CYCLOOXYGENASE INHIBITORS; EVOKED POTENTIALS; EXERCISE; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; KETOROLAC; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; REFLEX; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM;

EID: 34548457750     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00258.2007     Document Type: Article

References (36)

1. Chapleau MW, Hajduczok G, Abboud FM. Paracrine role of prostanoids in activation of arterial baroreceptors: an overview. Clin Exp Hypertens 13: 817-824, 1991.
2. Chen HI, Chapleau MW, McDowell TS, Abboud FM. Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium. Circ Res 67: 1394-1404, 1990.
3. Cryer B, Feldman M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med 104: 413-421, 1998.
4. Cui J, Zhang R, Wilson TE, Crandall CG. Spectral analysis of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol 286: H1101-H1106, 2004.
5. Davy KP, Herbert WG, Williams JH. Effect of indomethacin on the pressor responses to sustained isometric contraction in humans. J Appl Physiol 75: 273-278, 1993.
6. Doerzbacher KJ, Ray CA. Muscle sympathetic nerve responses to physiological changes in prostaglandin production in humans. J Appl Physiol 90: 624-629, 2001.
7. Dzau VJ, Packer M, Lilly LS, Swartz SL, Hollenberg NK, Williams GH. Prostaglandins in severe congestive heart failure. Relation to activation of the renin-angiotensin system and hyponatremia. N Engl J Med 310: 347-352, 1984.
8. Fagraeus L, Linnarsson D. Autonomic origin of heart rate fluctuations at the onset of muscular exercise. J Appl Physiol 40: 679-682, 1976.
9. Fontana GA, Pantaleo T, Bongianni F, Cresci F, Lavorini F, Guerra CT, Panuccio P. Prostaglandin synthesis blockade by ketoprofen attenuates respiratory and cardiovascular responses to static handgrip. J Appl Physiol 78: 449-457, 1995.
10. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875, 2001.
11. Gordon SM, Brahim JS, Rowan J, Kent A, Dionne RA. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical trials in a tissue injury model. Clin Pharmacol Ther 72: 175-183, 2002.
12. Hayes SG, Kindig AE, Kaufman MP. Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats. Am J Physiol Heart Circ Physiol 290: H2239-H2246, 2006.
13. Hollander AP, Bouman LN. Cardiac acceleration in man elicited by a muscle-heart reflex. J Appl Physiol 38: 272-278, 1975.
14. Kaufman MP, Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 10. p. 381-447.
15. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of group III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
16. Kaufman MP, Rybicki KJ, Waldrop TG, Ordway GA. Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol 57: 644-650, 1984.
17. Kurita A, Takase B, Hikita H, Uehata A, Nishioka T, Nagayoshi H, Satomura K, Nakao S. Frequency domain heart rate variability and plasma norepinephrine level in the coronary sinus during handgrip exercise. Clin Cardiol 22: 207-212, 1999.
18. Lee F, Shoemaker JK, McQuillan PM, Kunselman AR, Smith MB, Yang QX, Smith H, Gray K, Sinoway LI. Effects of forearm Bier block with bretylium on the hemodynamic and metabolic responses to handgrip. Am J Physiol Heart Circ Physiol 279: H586-H593, 2000.
19. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
20. McClain J, Hardy C, Enders B, Smith M, Sinoway L. Limb congestion and sympathoexcitation during exercise: implications for congestive heart failure. J Clin Invest 92: 2353-2359, 1993.
21. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
22. Middlekauff HR, Chiu J. Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol 287: H1944-H1949, 2004.
23. Middlekauff HR, Chiu J, Hamilton MA, Fonarow GC, Maclellan WR, Hage A, Moriguchi J, Patel J. Muscle mechanoreceptor sensitivity in heart failure. Am J Physiol Heart Circ Physiol 287: H1937-H1943, 2004.
24. Monahan KD, Ray CA. Cyclooxygenase inhibition and baroreflex sensitivity in humans. Am J Physiol Heart Circ Physiol 288: H737-H743, 2005.
25. Rotto DM, Hill JM, Schultz HD, Kaufman MP. Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction. Am J Physiol Heart Circ Physiol 259: H745-H750, 1990.
26. Rotto DM, Schultz HD, Longhurst JC, Kaufman MP. Sensitization of group III muscle afferents to static contraction by arachidonic acid. J Appl Physiol 68: 861-867, 1990.
27. Rowell LB. Central circulatory adjustments to dynamic exercise. In: Human Cardiovascular Control. New York: Oxford Univ. Press, 1993, p. 162-203.
28. Seals DR. Sympathetic neural discharge and vascular resistance during exercise in humans. J Appl Physiol 66: 2472-2478, 1989.
29. Sinoway L, Prophet S, Gorman I, Mosher T, Shenberger J, Dolecki M, Briggs R, Zelis R. Muscle acidosis during static exercise is associated with calf vasoconstriction. J Appl Physiol 66: 429-436, 1989.
30. Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol Renal Fluid Electrolyte Physiol 263: F181-F191, 1992.
31. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69: 145-182, 2000.
32. Stebbins CL, Maruoka Y, Longhurst JC. Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction. Circ Res 59: 645-654, 1986.
33. Sterns DA, Ettinger SM, Gray KS, Whisler SK, Mosher TJ, Smith MB, Sinoway LI. Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure. Circulation 84: 2034-2039, 1991.
34. Vallbo AB, Hagbarth KE, Torebjörk HE, Wallin BG. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919-957, 1979.
35. Waldrop TG, Rybicki KJ, Kaufman MP, Ordway GA. Activation of visceral thin-fiber afferents increases respiratory output in cats. Respir Physiol 58: 187-196, 1984.
36. Wilson JR, Kapoor SC. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol Heart Circ Physiol 265: H171-H175, 1993.