Peripheral ghrelin stimulates feeding behavior and positive energy balance in a sciurid hibernator

Hormones and Behavior

Volumn 59, Issue 4, 2011, Pages 512-519

  Healy, Jessica E ^a   Bateman, Jenna L ^a   Ostrom, Cara E ^a   Florant, Gregory L ^a  

^a Department of Ecosystem Science and Sustainability   (United States)

Author keywords

Behavior; Food intake; Ghrelin; Hibernator

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID; GHRELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; AUTUMN; BODY MASS; COLORIMETRY; CONTROLLED STUDY; ENERGY BALANCE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; HIBERNATION; LOCOMOTION; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SPRING; SQUIRREL; SUMMER; WESTERN BLOTTING; WINTER;

ACETYL-COA CARBOXYLASE; ADENYLATE KINASE; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; EATING; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FEEDING BEHAVIOR; GHRELIN; HYPOTHALAMUS; MOTOR ACTIVITY; PHOSPHORYLATION; RANDOM ALLOCATION; SCIURIDAE;

EID: 79954745785     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.01.013     Document Type: Article

References (35)

1. Andersson U., Filipsson K., Abbott C.R., Woods A., Smith K., Bloom S.R., Carling D., Small C.J. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 2004, 279:12005-12008.
2. Andrews Z.B., Liu Z.W., Walllingford N., Erion D.M., Borok E., Friedman J.M., Tschop M.H., Shanabrough M., Cline G., Shulman G.I., Coppola A., Gao X.B., Horvath T.L., Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008, 454:846-851.
3. Armitage K.B., Shulenberger E. Evidence for a circannual metabolic cycle in Citellus tridecemlineatus, a hibernator. Comp. Biochem. Physiol. 1972, 42:667-688.
4. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Fujimiya M., Katsuura G., Makino S., Fujino M.A., Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinol 2001, 74:143-147.
5. Bradley S.P., Pattullo L.M., Patel P.N., Prendergast B.J. Photoperiodic regulation of the orexigenic effects of ghrelin in Siberian hamsters. Horm. Behav. 2010, 58:647-652.
6. Carlini V.P., Monzon M.E., Varas M.M., Cragnolini A.B., Schi€oth H.B., Scimonelli T.N., de Barioglioa S.R. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem. Biophys. Res. Commun. 2002, 299:739-743.
7. Castaneda T.R., Jurgens H., Wiedmer P., Pfluger P., Diano S., Horvath T.L., Tang-Christensen M., Tschop M.H. Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. J. Nutr. 2005, 135:1314-1319.
8. Chen H.Y., Trumbauer M.E., Chen A.S., Weingarth D.T., Adams J.R., Frazier E.G., Shen Z., Marsh D.J., Feighner S.D., Guan X.M., Ye Z., Nargund R.P., Smith R.G., Van der Ploeg L.H., Howard A.D., MacNeil D.J., Qian S. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 2004, 145:2607-2612.
9. Cowley M.A., Smith R.G., Diano S., Tschop M., Pronchuck N., Grove K.L., Strasburger C.J., Bidlingmaier M., Esterman M., Heiman M.L., Garcia-Segura L.M., Nillni E.A., Mendez P., Low M.J., Sotonyi P., Friedman J.M., Liu H., Pinto S., Colmers W.F., Cone R.D., Horvath T.L. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
10. Cummings D.E. Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol. Behav. 2006, 89:71-84.
11. Dark J. Annual lipid cycles in hibernators: integration of physiology and behavior. Annu. Rev. Nutr. 2005, 25:469-497.
12. Ferrini F., Salio C., Lossi L., Merighi A. Ghrelin in central neurons. Curr. Neuropharmacol. 2009, 7:37-49.
13. Florant G.L., Fenn A.M., Healy J.E., Wilkerson G.K., Handa R.J. To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris). J. Exp. Biol. 2010, 213:2031-2037.
14. Healy J.E., Ostrom C.E., Wilkerson G.K., Florant G.L. Serum ghrelin concentrations change with physiological state in a sciurid hibernator (Spermophilus lateralis). Gen. Comp. Endocrinol. 2010, 166:372-378.
15. Heller H.C., Ruby N.F. Sleep and circadian rhythms in mammalian torpor. Annu. Rev. Physiol. 2004, 66:275-289.
16. Hou Z., Miao Y., Gao L., Pan H., Zhu S. Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat. Regul. Pept. 2006, 134:126-131.
17. Jászberényi M., Bujdosó E., Bagosi Z., Telegdy G. Mediation of the behavioral, endocrine and thermoregulatory actions of ghrelin. Horm. Behav. 2006, 50:266-273.
18. Jerlhag E., Egecioglu E., Dickson S.L., Andersson M., Svensson L., Engel J.A. Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict. Biol. 2006, 11:45-54.
19. Joseph S.A., Knigge K.A., Kalejs L.M., Hoffman R.A., Reid P. In: A Stereotaxic Atlas of the Brain of the 13-line Ground Squirrel (Citellus tridecemlineatus) 1966, Edgewood Arsenal Special Publications, Edgewood, MD.
20. Kamegai J., Tamura H., Shimizu T., Ishii S., Sugihara H., Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001, 50:2438-2443.
21. Keen-Rhinehart E., Bartness T.J. Peripheral ghrelin injections stimulate food intake, foraging, and food hoarding in Siberian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R716-R722.
22. Kenagy G.J., Sharbaugh S.M., Nagy K.A. Annual cycle of energy and time expenditure in a golden-mantled ground squirrel population. Oecologia 1989, 78:269-282.
23. Kodomari I., Maruoka T., Yamauchi R., Wada E., Wada K. Ghrelin alters postnatal endocrine secretion and behavior in mouse offspring. Neurochem. Int. 2009, 54:222-228.
24. Kohno D., Sone H., Minokoshi Y., Yada T. Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochem. Biophys. Res. Commun. 2008, 366:388-392.
25. Kojima M., Kangawa K. Structure and function of ghrelin. Results. Probl. Cell. Differ. 2008, 46:89-115.
26. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
27. Kola B., Hubina E., Tucci S.A., Kirkham T.C., Garcia E.A., Mitchell S.E., Williams L.M., Hawley S.A., Hardie D.G., Grossman A.B., Korbonits M. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J. Biol. Chem. 2005, 280:25196-25201.
28. Lage R., Vazquez M.J., Varela L., Saha A.K., Vidal-Puig A., Nogueiras R., Dieguez C., Lopez M. Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J. 2010, 24:2670-2679.
29. Seoane L.M., Lopez M., Tovar S., Casanueva F., Senaris R., Dieguez C. Agouti- related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinol 2003, 144:544-551.
30. Strassburg S., Anker S., Castaneda T., Burget L., Perez-Tilve D., Pfluger P.T., Nogueiras R., Halem H., Dong J.Z., Culler M., Datta R., Tschop M.H. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E78-E84.
31. Szentirmai E., Kapas L., Krueger J.M. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292:R575-R585.
32. Theander-Carrillo C., Wiedmer P., Cettour-Rose P., Nogueiras R., Perez-Tilve D., Pfluger P., Castaneda T.R., Muzzin P., Schurmann A., Szanto I., Tschop M.H., Rohner- Jeanrenaud F. Ghrelin action in the brain controls adipocyte metabolism. J. Clin. Invest. 2006, 116:1983-1993.
33. Torke K.G., Twente J.W. Behavior of Spermophilus lateralis between periods of hibernation. J. Mamm. 1977, 58:385-390.
34. Toshinai K., Date Y., Murakami N., Shimada M., Mondal M.S., Shimbara T., Guan J.L., Wang Q.P., Funahashi H., Sakurai T., Shioda S., Matsukura S., Kangawa K., Nakazato M. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinol 2003, 144:1506-1512.
35. Verty A.N.A., Allen A.M., Oldfield B.J. The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat. Endocrinol 2010, 151:4236-4246.