Recombinant LipL32 and LigA from Leptospira are unable to stimulate protective immunity against leptospirosis in the hamster model

Vaccine

Volumn 29, Issue 18, 2011, Pages 3413-3418

  Deveson Lucas, Deanna S ^a,b   Cullen, Paul A ^a   Lo, Miranda ^a   Srikram, Amporn ^b   Sermswan, Rasana W ^b   Adler, Ben ^a  

^a MONASH UNIVERSITY   (Australia)

^b KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Immunity; Leptospira spp.; LigA; LipL32

Indexed keywords

BACTERIAL VACCINE; HYBRID PROTEIN; LIGANI PROTEIN; LIPL32 LIGANI FUSION PROTEIN; OUTER MEMBRANE PROTEIN LIPL32; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HAMSTER; IMMUNOGENICITY; IMMUNOSTIMULATION; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEROTYPE; TREATMENT FAILURE; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BACTERIAL VACCINES; CRICETINAE; DISEASE MODELS, ANIMAL; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; LIPOPROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 79954680218     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.02.084     Document Type: Article

References (32)

1. Farrelly H.E., Adler B., Faine S. Opsonic monoclonal antibodies against lipopolysaccharide antigens of Leptospira interrogans serovar Hardjo. J Med Microbiol 1987, 23:1-7.
2. Levett P.N. Leptospirosis. Clin Microbiol Rev 2001, 14:296-326.
3. Brown R.A., Blumerman S., Gay C., Bolin C., Duby R., Baldwin C.L. Comparison of three different leptospiral vaccines for induction of a type 1 immune response to Leptospira borgpetersenii serovar Hardjo. Vaccine 2003, 21:4448-4458.
4. Faine S., Adler B., Bolin C., Perolat P. Leptospira and leptospirosis 1999, MediSci, Australia. 2nd ed.
5. Cullen P.A., Xu X.Y., Matsunaga J., Sanchez Y., Ko A.I., Haake D.A., et al. Surfaceome of Leptospira spp. Infect Immun 2005, 73:4853-4863.
6. Shang E.S., Exner M.M., Summers T.A., Martinich C., Champion C.I., Hancock R.E., et al. The rare outer membrane protein OmpL1, of pathogenic Leptospira species is a heat-modifiable porin. Infect Immun 1995, 63:3174-3181.
7. Branger C., Sonrier C., Chatrenet B., Klonjkowski B., Ruvoen-Clouet N., Aubert A., et al. Identification of the hemolysis-associated protein 1 as a cross-protective immunogen of Leptospira interrogans by adenovirus-mediated vaccination. Infect Immun 2001, 69:6831-6838.
8. Haake D.A., Chao G., Zuerner R.L., Barnett J.K., Barnett D., Mazel M., et al. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect Immun 2000, 68:2276-2285.
9. Guerreiro H., Croda J., Flannery B., Mazel M., Matsunaga J., Galvao Reis M., et al. Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans. Infect Immun 2001, 69:4958-4968.
10. Seixas F.K., da Silva E.F., Hartwig D.D., Cerqueira G.M., Amaral M., Fagundes M.Q., et al. Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge. Vaccine 2007, 26:88-95.
11. Adler B., de la Peña Moctezuma A. Leptospira and leptospirosis. Vet Microbiol 2010, 140:287-296.
12. Hoke D.E., Egan S., Cullen P.A., Adler B. LipL32 is an extracellular matrix-interacting protein of Leptospira spp. and Pseudoalteromonas tunicata. Infect Immun 2008, 76:2063-2069.
13. Hauk P., Macedo F., Romero E.C., Vasconcellos S.A., de Morais Z.M., Barbosa A.S., et al. In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectin. Infect Immun 2008, 76:2642-2650.
14. Tung J.Y., Yang C.W., Chou S.W., Lin C.C., Sun Y.J. Calcium binds to LipL32, a lipoprotein from pathogenic Leptospira, and modulates fibronectin binding. J Biol Chem 2010, 285:3245-3252.
15. Murray G.L., Srikram A., Hoke D.E., Wunder E.A., Henry R., Lo M., et al. Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans. Infect Immun 2009, 77:952-958.
16. Lottersberger J., Guerrero S.A., Tonarelli G.G., Frank R., Tarabla H., Vanasco N.B. Epitope mapping of pathogenic Leptospira LipL32. Lett Appl Microbiol 2009, 49:641-645.
17. Matsunaga J., Barocchi M.A., Croda J., Young T.A., Sanchez Y., Siqueira I., et al. Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol Microbiol 2003, 49:929-945.
18. Matsunaga J., Sanchez Y., Xu X., Haake D.A. Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA. Infect Immun 2005, 73:70-78.
19. Choy H.A., Kelley M.M., Chen T.L., Moller A.K., Matsunaga J., Haake D.A. Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen. Infect Immun 2007, 75:2441-2450.
20. Koizumi N., Watanabe H. Leptospiral immunoglobulin-like proteins elicit protective immunity. Vaccine 2004, 22:1545-1552.
21. Silva E.F., Medeiros M.A., McBride A.J., Matsunaga J., Esteves G.S., Ramos J.G., et al. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine 2007, 25:6277-6286.
22. Petrovsky N., Aguilar J.C. Vaccine adjuvants: current state and future trends. Immunol Cell Biol 2004, 82:488-496.
23. Johnson R.C., Walby J., Henry R.A., Auran N.E. Cultivation of parasitic leptospires: effect of pyruvate. Appl Microbiol 1973, 26:118-119.
24. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual 1989, Cold Spring Harbour Laboratory Press, New York. 2nd ed.
25. Murray G.L., Morel V., Cerqueira G.M., Croda J., Srikram A., Henry R., et al. Genome-wide transposon mutagenesis in pathogenic Leptospira species. Infect Immun 2009, 77:810-816.
26. Haake D.A. Hamster model of leptospirosis. Curr Protoc Microbiol 2006, [Chapter 12:Unit 12E 2].
27. Srikram A., Zhang K., Bartpho T., Lo M., Hoke D.E., Sermswan R.W., et al. Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant. J Infect Dis 2011.
28. Haake D.A., Mazel M.K., McCoy A.M., Milward F., Chao G., Matsunaga J., et al. Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection. Infect Immun 1999, 67:6572-6582.
29. Branger C., Chatrenet B., Gauvrit A., Aviat F., Aubert A., Bach J.M., et al. Protection against Leptospira interrogans sensu lato challenge by DNA immunization with the gene encoding hemolysin-associated protein 1. Infect Immun 2005, 73:4062-4069.
30. Habarta A., Abreu P.A., Olivera N., Hauk P., Cedola M.T., Ferrer M.F., et al. Increased immunogenicity to LipL32 of Leptospira interrogans when expressed as a fusion protein with the Cholera toxin B subunit. Curr Microbiol 2010.
31. Palaniappan R.U., McDonough S.P., Divers T.J., Chen C.S., Pan M.J., Matsumoto M., et al. Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infection. Infect Immun 2006, 74:1745-1750.
32. Adler B., Faine S. Host immunological mechanisms in resistance of mice to leptospiral infections. Infect Immun 1977, 17:67-72.