Microfluidic devices with mass spectrometry detection

Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition

Volumn , Issue , 2007, Pages 1459-1506

  Lazar, Iulia M ^a  

^a VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79954629548     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (236)

1. Manz, A., Graber, N., Widmer, H.M., Miniaturized total chemical-analysis systems-a novel concept for chemical sensing, Sens. Actuat. B, 1, 244-248, 1990.
2. Manz, A., Fettinger, J.C., Verpoorte, E., Ludi, H., Widmer, H.M., Harrison D.J., Micromachining of monocrystalline silicon and glass for chemical-analysis systems-a look into next century technology or just a fashionable craze, Trends Anal. Chem., 10, 144-149, 1991.
3. Manz, A., Harrison, D.J., Verpoorte, E.M.J., Fettinger, J.C., Paulus, A., Lüdi, H., Widmer, H.M., Planar chip technology for miniaturization and integration of separation techniques into monitoring systems. Capillary electrophoresis on a chip, J. Chromatogr., 593, 253-258, 1992.
4. Harrison, D.J., Manz, A., Fan, Z.H., Ludi, H., Widmer, H.M., Capillary electrophoresis and sample injection systems integrated on a planar glass chip, Anal. Chem., 64, 1926-1932, 1992.
5. Harrison, D.J., Fluri, K., Fan, Z., Effenhauser, C.S., Manz, A., Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip, Science, 261, 895-897, 1993.
6. Harrison, D.J., Glavina PG, Manz A. 1993. Towards Miniaturized Electrophoresis and Chemical-Analysis Systems on Silicon-an Alternative to Chemical Sensors, Sens. Actuat. B, 10, 107-116, 1993.
7. Jacobson, S.C., Hergenroder, R., Koutny, L.B., Warmack, R.J., Ramsey, J.M, Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices, Anal. Chem., 66, 1107-1113, 1994.
8. Jacobson, S.C., Hergenroder, R., Koutny, L.B., Ramsey, J.M., High-speed separations on a microchip, Anal. Chem., 66, 1114-1118, 1994.
9. Jacobson, S.C., Hergenroder, R., Koutny, L.B., Ramsey, J.M., Open-channel electrochromatography on a microchip, Anal. Chem., 66, 2369-2373, 1994.
10. Woolley, A.T., Mathies, R.A., Ultra-high-speed DNA-sequencing using capillary electrophoresis chips, Anal. Chem., 67, 3676-3680, 1995.
11. Jakeway, S.C., de Mello, A.J., Russell, E.L., Miniaturized total analysis systems for biological analysis, Fresenius J. Anal. Chem., 366, 525-539, 2000.
12. Greenwood, P.A., Greenway, G.M., Sample manipulation in micrototal analysis systems, Trends Anal. Chem., 21, 726-740, 2002.
13. Reyes, D.R., Iossifidis, D., Auroux, P.-A., Manz, A., Micro total analysis systems. 1. Introduction, theory, and technology, Anal. Chem., 74, 2623-2636, 2002.
14. Auroux, P.A., Iossifidis, D., Reyes, D.R., Manz, A., Micro total analysis systems. 2. Analytical standard operations and applications. Anal. Chem., 74, 2637-2652, 2002.
15. Becker, H., Gärtner, C., Polymer microfabrication methods for microfluidic analytical applications, Electrophoresis, 21, 12-26, 2000.
16. Khandurina, J., Guttman, A., Bioanalysis in microfluidic devices, J. Chromatogr. A, 943, 159-183, 2002.
17. Thomas, G.A., Farquar, H.D., Sutton, S., Hammer, R.P., Soper, S.A., BioMEMS using electrophoresis for the analysis of genetic mutations, Expert Rev. Mol. Diagn., 2, 429-47, 2002.
18. Landers, J.P., Molecular diagnostics on electrophoretic microchips, Anal. Chem., 75, 2919-2927, 2003.
19. Weigl, B.H., Bardell, R.L., Cabrera, C.R., Lab-on-a-chip for drug development, Adv. Drug Deliv. Rev., 55, 349-377, 2003.
20. Ziaie, B., Baldi, A., Lei, M., Gu, Y., Siegel, R.A., Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery, Adv. Drug Deliv. Rev., 56, 145-172, 2004.
21. Madou, M., Fundamentals of Microfabrication, Boca Raton: CRC Press, 1997.
22. Jacobson, S.C., Culbertson, C.T., Daler J.E., Ramsey J.M., Microchip structures for submillisecond electrophoresis, Anal. Chem., 70, 3476-3480, 1998.
23. Emrich, C.A., Tian, H., Medintz, I.L., Mathies, R.A., Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis, Anal. Chem., 74, 5076-5083, 2002.
24. Aborn, J.H., El-Difrawy, S.A., Novotny, M., Gismondi, E.A., Lam, R., Matsudaira, P., Mckenna, B.K., O’Neil, T., Streechon, P., Ehrlich, D.J., A 768-lane microfabricated system for high-throughput DNA sequencing, Lab Chip, 5, 669-674, 2005.
25. Stachowiak, T.B., Svec, F., Fréchet, J.M.J., Chip electrochromatography, J. Chromatogr. A, 1044, 97-111, 2004.
26. Ro, K.W., Nayak, R., Knapp, D.R., Monolithic media in microfluidic devices for proteomics, Electrophoresis, 27, 3547-3558, 2006.
27. Kutter, J.P., Jacobson, S.C., Matsubara, N., Ramsey, J.M., Solvent-programmed microchip openchannel electrochromatography, Anal. Chem., 70, 3291-3297, 1998.
28. He, B., Ji, J., Regnier, F.E., Capillary electrochromatography of peptides in a microfabricated system, J. Chromatogr. A, 853, 257-262, 1999.
29. Oleschuk, R.D., Shultz-Lockyear, L.L., Ning, Y., Harrison, D.J., Trapping of bead-based reagents within microfluidic systems: on-chip solid-phase extraction and electrochromatography, Anal. Chem., 72, 585-590, 2000.
30. Ceriotti, L., de Rooij, N.F., Verpoorte, E., An integrated fritless column for on-chip capillary electrochromatography with conventional stationary phases, Anal. Chem., 74, 639-647, 2002.
31. Breadmore, M.C., Shrinivasan, S., Karlinsey, J., Ferrance J.P., Norris, P.M., Landers, J.P., Towards a microchip-based chromatographic platform. Part 2: Sol-gel phases modified with polyelectrolyte multilayers for capillary electrochromatography, Electrophoresis, 24, 1261-1270, 2003.
32. Lazar, I.M., Li L.J., Yang, Y., Karger, B.L., Microfluidic device for capillary electrochromatographymass spectrometry, Electrophoresis, 24, 3655-3662, 2003.
33. Moore, A.W., Jacobson, S.C., Ramsey, J. M., Microchip separations of neutral species via micellar electrokinetic capillary chromatography, Anal. Chem., 67, 4184-4189, 1995.
34. Ramsey, J.D., Collins, G.E., Integrated microfluidic device for solid-phase extraction coupled to micellar electrokinetic chromatography separation, Anal. Chem., 77, 6664-6670, 2005.
35. Macounová, K., Cabrera, C.R., Holl, M.R., Yager, P., Generation of naturalpHgradients in microfluidic channels for use in isoelectric focusing, Anal. Chem., 72, 3745-3751, 2000.
36. Cabrera, C.R., Finlayson, B., Yager, P., Formation of natural pH gradients in a microfluidic device under flow conditions: model and experimental validation, Anal. Chem., 73, 658-666, 2001.
37. Macounová, K., Cabrera, C.R., Yager, P., Concentration and separation of proteins in microfluidic channels on the basis of transverse IEF, Anal. Chem., 73, 1627-1633, 2001.
38. Raisi, F., Belgrader, P., Borkholder, D.A., Herr, A.E., Kintz, G.J., Pourhamadi, F., Taylor, M.T., Northrop, M.A., Microchip isoelectric focusing using a miniature scanning detection system, Electrophoresis, 22, 2291-2295, 2001.
39. Tan, A., Pashkova, A., Zang, L., Foret, F., Karger, B.L., A miniaturized multichamber solution isoelectric focusing device for separation of protein digests, Electrophoresis, 23, 3599-3607, 2002.
40. Huang, T., Pawliszyn, J., Microfabrication of a tapered channel for isoelectric focusing with thermally generated pH gradient, Electrophoresis, 23, 3505-3510, 2002.
41. Tan, W., Fan, Z.H., Qiu, C.X., Ricco, A.J., Gibbons, I., Miniaturized capillary isoelectric focusing in plastic microfluidic devices, Electrophoresis, 23, 3638-3645, 2002.
42. Zilberstein, G.V., Baskin, E.M., Bukshpan, S., Parallel processing in the isoelectric focusing chip, Electrophoresis, 24, 3735-3744, 2003.
43. Herr, A.E., Molho, J.I., Drouvalakis, K.A., Mikkelsen, J.C., Utz, P.J., Santiago, J.G., Kenny, T.W., On-chip coupling of isoelectric focusing and free solution electrophoresis for multidimensional separations, Anal. Chem., 75, 1180-1187, 2003.
44. Xu, Y., Zhang, C.-X, Janasek, D., Manz, A., Sub-second isoelectric focusing in free flow using a microfluidic device, Lab Chip, 3, 224-227, 2003.
45. Zilberstein, G.V., Baskin, E.M., Bukshpan, S., Korol, L.E., Parallel isoelectric focusing II, Electrophoresis, 25, 3643-3651, 2004.
46. Li, Y., Buch, J.S., Rosenberger, F., DeVoe, D.L., Lee, C.S., Integration of isoelectric focusing with parallel sodium dodecyl sulfate gel electrophoresis for multidimensional protein separations in a plastic microfluidic network, Anal. Chem., 76, 742-748, 2004.
47. Cui, H., Horiuchi, K., Dutta, P., Ivory, C.F., Multistage isoelectric focusing in a polymeric microfluidic chip, Anal. Chem., 77, 7878-7886, 2005.
48. Cui, H., Horiuchi, K., Dutta, P., Ivory, C.F., Isoelectric focusing in a poly(dimethylsiloxane) microfluidic chip, Anal. Chem., 77, 1303-1309, 2005.
49. Yao, B., Yang, H., Liang, Q., Luo, G., Wang, L., Ren, K., Gao, Y., Wang, Y., Qiu, Y., High-speed, whole-column fluorescence imaging detection for isoelectric focusing on a microchip using an organic light emitting diode as light source, Anal. Chem., 78, 5845-5850, 2006.
50. Das, C., Fan, Z.H., Effects of separation length and voltage on isoelectric focusing in a plastic microfluidic device, Electrophoresis, 27, 3619-3626, 2006.
51. Song, Y.-A., Hsu, S., Stevens, A.L., Han, H., Continuous-flow pL-based sorting of proteins and peptides in a microfluidic chip using diffusion potential, Anal. Chem., 78, 3528-3536, 2006.
52. Veerland, W.N., Williams, S.J., Barron, A.E., Sassi, A.P., Tandem isotachophoresis-zone electrophoresis via base-mediated destacking for increased detection sensitivity in microfluidic systems, Anal. Chem., 73, 3059-3065, 2003.
53. Jeong, Y., Choi, K., Kang, M.K., Chun, K., Chung, D.S., Transient isotachophoresis of highly saline samples using a microchip, Sens. Actuat. B, 104, 269-275, 2005.
54. Chen, L., Prest, J.E., Fielden, P.R., Goddard, N.J., Manz, A., Day, P.J.R., Miniaturized isotachophoresis analysis, Lab Chip, 6, 474-487, 2006.
55. Janasek, D., Schilling, M., Franzke, J., Manz, A., Isotachophoresis in free-flow using a miniaturized device, Anal. Chem., 78, 3815-3819, 2006.
56. Bousse, L., Mouradian, S., Minalla, A., Yee, H., Williams, K., Dubrow, R., Protein sizing on a microchip, Anal. Chem., 73, 1207-1212, 2001.
57. Jin, L.J., Giordano, B.C., Landers, J., Dynamic labeling during capillary or microchip electrophoresis for laser-induced fluorescence detection of protein-SDS complexes without pre- or postcolumn labeling, Anal. Chem., 73, 4994-4999, 2001.
58. Hatch, A.V., Herr, A.E., Throckmorton, D.J., Brennan, J.S., Singh, A.K., Integrated preconcentration SDS-PAGE of proteins in microchips using photopatterned cross-linked polyacrylamide gels, Anal. Chem., 78, 4976-4984, 2006.
59. Agirregabiria, M., Blanco, F.J., Berganzo, J., Fullaondo, A., Zubiaga, A.M., Mayora, K., Ruano-Lopez, J.M., SDS-CGE of proteins in microchannels made of SU-8 films, Electrophoresis, 27, 3627-3634, 2006.
60. Rocklin, R.D., Ramsey, R.S., Ramsey, J. M., A microfabricated fluidic device for performing twodimensional liquid-phase separations, Anal. Chem., 72, 5244-5249, 2000.
61. Ramsey, J.D., Jacobson, S.C., Culbertson, C.T., Ramsey, J.M., High-efficiency, twodimensional separations of protein digests on microfluidic devices, Anal. Chem., 75, 3758-3764, 2003.
62. Gottschlich, N., Jacobson, S.C., Culbertson, C.T., Ramsey, J.M., Two-dimensional electrochromatography/capillary electrophoresis on a chip, Anal. Chem., 73, 2669-2674, 2001.
63. Shadpour, H., Soper, S.A., Two-dimensional electrophoretic separation of proteins using poly (methylmethacrylate) microchips, Anal. Chem., 78, 3519-3527, 2006.
64. Buch, J.S., Rosenberger, F., Highsmith, W.E., Kimball, C., DeVoe, D.L., Lee, C.S., Denaturing gradient-based two-dimensional gene mutation scanning in a polymer microfluidic network, Lab Chip, 5, 392-400, 2005.
65. Griebel, A., Rund, S., Schonfeld, F., Dorner, W., Konrad, R., Hardt, S., Integrated polymer chip for two-dimensional capillary gel electrophoresis, Lab Chip, 4, 18-23, 2004.
66. Usui, K., Hiratsuka, A., Shiseki, K., Maruo, Y., Matsushima, T., Takahashi, K., Unuma, Y., Sakairi, K., Namatame, I., Ogawa, Y., Yokoyama, K., A self-contained polymeric 2-de chip system for rapid and easy analysis, Electrophoresis, 27, 3635-3642, 2006.
67. Ölvecká, E., Kaniansky, D., Pollák, B., Stanislawski, B., Separation of proteins by zone electrophoresis on-line coupled with isotachophoresis on a column-coupling chip with conductivity detection, Electrophoresis, 25, 3865-3874, 2004.
68. Weinberger, R., Practical Capillary Electrophoresis, Academic Press, Inc., 1993.
69. De Hoffmann, E., Stroobant, V., Mass Spectrometry. Principles and Applications. 2nd ed., JohnWiley & Sons, 2002.
70. Herbert, C.J., Johnstone, R.A.W., Mass Spectrometry Basics, Boca Raton: CRC Press, 2003.
71. Gross, J.H., Mass Spectrometry. A Textbook, Springer, 2004.
72. Lazar, I.M., Ramsey, R.S., Sundberg, S., Ramsey, J.M., Subattomole-sensitivity microchip nanoelectrospray source with time-of-flight mass spectrometry detection, Anal. Chem., 71, 3627-3631, 1999.
73. Figeys, D., Pinto, D., Proteomics on a chip: promising developments, Electrophoresis, 22, 208-216, 2001.
74. Figeys, D., Adapting arrays and lab-on-a-chip technology for proteomics, Proteomics, 2, 373-382, 2002.
75. Limbach, P.A., Meng, Z., Integrating micromachined devices with modern mass spectrometry, Analyst, 127, 693-700, 2002.
76. Foret, F., Preisler, J., Liquid phase interfacing and miniaturization in matrix-assisted laser desorption/ionization mass spectrometry, Proteomics, 2, 360-372, 2002.
77. Marko-Varga, G., Nilsson, J., Laurell, T., New directions of miniaturization within the proteomics research area, Electrophoresis, 24, 3521-3532, 2003.
78. Lion, N., Rohner, T.C., Dayon, L., Arnaud, I.L., Damoc, E., Youhnovski, N., Wu, Z.-Y., Roussel, C., Josserand, J., Jensen, H., Rossier, J.S., Przybylski, M., Girault, H.H., Microfluidic systems in proteomics, Electrophoresis, 24, 3533-3562, 2003.
79. Marko-Varga, G., Nilsson, J., Laurell, T., New directions of miniaturization within the biomarker research area, Electrophoresis, 25, 3479-3491, 2004.
80. Ohnesorge, J., Neusüß, C., Wätzig, H., Quantitation in capillary electrophoresis-mass spectrometry, Electrophoresis, 26, 3973-3987, 2005.
81. DeVoe, D.L., Lee, C.S., Microfluidic technologies for MALDI-MS in proteomics, Electrophoresis, 27, 3559-3568, 2006.
82. Lazar, I.M., Grym, J., Foret, F., Microfabricated devices: a new sample introduction approach to mass spectrometry, Mass Spectrom. Rev., 25, 573-594, 2006.
83. Xue, Q.F., Foret, F., Dunayevskiy, Y.M., Zavracky, P.M., McGruer, N.E., Karger. B.L., Multichannel microchip electrospray mass spectrometry, Anal. Chem., 69, 426-430, 1997.
84. Xue, Q.F., Dunayevskiy, Y.M., Foret, F., Karger, B.L., Integrated multichannel microchip electrospray ionization mass spectrometry: analysis of peptides from on-chip tryptic digestion of melittin, Rapid Commun. Mass Spectrom., 11, 1253-1256, 1997.
85. Ramsey, R.S., Ramsey, J.M., Generating electrospray from microchip devices using electroosmotic pumping, Anal. Chem., 69, 1174-1178, 1997.
86. Rohner, T.C., Rossier, J.S., Girault H.H., Polymer microspray with an integrated thick-film microelectrode, Anal. Chem., 73, 5353-5357, 2001.
87. Huikko, K., Östman, P, Grigoras, K., Tuomikoski, S., Tiainen, V.-M., Soininen, A., Puolanne, K., Manz, A., Franssila, S., Kostiainen, R., Kotiaho, T., Poly(dimethylsiloxane) electrospray devices fabricated with diamond-like carbon-poly(dimethylsiloxane) coated SU-8 masters, Lab Chip, 3, 67-72, 2003.
88. Lozano, P., Martínez-Sánchez, M., Lopez-Urdiales, J.M., Electrospray emission from nonwetting flat dielectric surfaces, J. Coll. Inter. Sci., 276, 392-399, 2004.
89. Wang, Y.-X., Cooper, J.W, Lee, C.S., DeVoe, D. L., Efficient electrospray ionization from polymer microchannels using integrated hydrophobic membranes, Lab Chip, 4, 363-367, 2004.
90. Zhang, B., Liu, H, Karger, B.L., Foret, F., Microfabricated devices for capillary electrophoresiselectrospray mass spectrometry, Anal. Chem., 71, 3258-3264, 1999.
91. Brivio, M., Oosterbroeck, R.E., Verboom, W., van den Berg, A., Reinhoudt, D.N., Simple chipbased interfaces for on-line monitoring of supramolecular interactions by nano-ESI MS, Lab Chip, 5, 1111-1122, 2005.
92. Grym, J., Otevřel M., Foret, F., Aerodynamic mass spectrometry interfacing of microdevices without electrospray tips, Lab Chip, 6, 1306-1314, 2006.
93. Li, J., Kelly, J.F., Chemushevich, I., Harrison, D.J., Thibault, P., Separation and identification of peptides from gel-isolated membrane proteins using a microfabricated device for combined capillary electrophoresis/nanoelectrospray mass spectrometry, Anal. Chem., 72, 599-609, 2000.
94. Li, J., Thibault, P., Bings, N.H., Skinner, C.D., Wang, C., Colyer, C., Harrison, J., Integration of microfabricated devices to capillary electrophoresis-electrospray mass spectrometry using a low dead volume connection: Application to rapid analyses of proteolytic digests, Anal. Chem., 71, 3036-3045, 1999.
95. Bings, N.H., Wang, C., Skinner, C.D., Colyer, C.L., Thibault, P., Harrison, D.J., Microfluidic devises connected to fused-silica capillaries with minimal dead volume, Anal. Chem., 71, 3292-3296, 1999.
96. Zhang, B., Foret, F., Karger, B.L., A microdevice with integrated liquid junction for facile peptide and protein analysis by capillary electrophoresis/electrospray mass spectrometry, Anal. Chem., 72, 1015-1022, 2000.
97. Lazar, I.M., Ramsey, R.S., Jacobson, S.C., Foote, R.S., Ramsey, J.M., Novel microfabricated device for electrokinetically induced pressure flow and electrospray ionization mass spectrometry, J. Chromatogr. A, 892, 195-201, 2000.
98. Vrouwe, E.X., Gysler, J., Tjaden, U.R., van der Greef, J., Chip-based capillary electrophoresis with an electrodless nanospary interface, Rapid Commun. Mass Spectrom., 14, 1682-1688, 2000.
99. Meng, Z., Qi, S., Soper, S.A., Limbach, P.A., Interfacing a polymer-based micromachined device to a nanoelectrospray ionization Fourier transform ion cyclotron resonance mass spectrometer, Anal. Chem., 73, 1286-1291, 2001.
100. Sung, W.-C., Huang, S.-Y., Liao, P.-C., Lee, G.-B, Li, C.-W., Chen, S.-H., Poly(dimethylsiloxane)- based microfluidic device with electrospray ionization mass spectrometry for protein identification, Electrophoresis, 24, 3648-3654, 2003.
101. Ssenyange, S., Taylor, J., Harrison, D.J., McDermott, M.T., A glassy carbon microfluidic device for electrospray mass spectrometry, Anal. Chem., 76, 2393-2397, 2004.
102. Yang, Y., Li, C., Kameoka, J., Lee, K.H., Craighead, H.G., A polymeric microchip with integrated tips and in situ polymerized monolith for electrospray mass spectrometry, Lab Chip, 5, 869-876, 2005.
103. Figeys, D., Aebersold, R., Nanoflow solvent gradient delivery from a microfabricated device for protein identifications by electrospray ionization mass spectrometry, Anal. Chem., 70, 3721-3727, 1998.
104. Liu, H.H., Felten, C., Xue, Q.F., Zhang, B.L., Jedrzejewski, P., Karger. B.L., Foret, F., Development of multichannel devices with an array of electrospray tips far high-throughput mass spectrometry, Anal. Chem., 72, 3303-3310, 2000.
105. Xu, N., Lin, Y.H., Hofstadler, S.A., Matson, D., Call, C.J., Smith, R.D., A microfabricated dialysis device for sample cleanup in electrospray ionization mass spectrometry, Anal. Chem., 70, 3553-3556, 1998.
106. Figeys, D., Ning, Y.B., Aebersold, R., A microfabricated device for rapid protein identification by microelectrospray ion trap mass spectrometry, Anal. Chem., 69, 3153-3160, 1997.
107. Figeys, D., Gygi, S.P., McKinnon, G., Aebersold, R., An integrated microfluidics tandem mass spectrometry system for automated protein analysis, Anal. Chem., 70, 3728-3734, 1998.
108. Figeys, D., Lock, C., Taylor, L., Aebersold, R., Microfabricated device coupled with an electrospray ionization quadrupole time-of-flight mass spectrometer: Protein identifications based on enhancedresolution mass spectrometry and tandem mass spectrometry data, Rapid Commun. Mass Spectrom., 12, 1435-1444, 1998.
109. Figeys, D., Aebersold, R., Microfabricated modules for sample handling, sample concentration and flow mixing: application to protein analysis by tandem mass spectrometry, J. Biomech. Eng., 121, 7-12, 1999.
110. Razunguzwa, T.T., Lenke, J., Timperman, A.T., An electrokinetic/hydrodynamic flow microfluidic CE-ESI-MS interface utilizing a hydrodynamic flow restrictor for delivery of samples under low EOF conditions, Lab Chip, 5, 851-855, 2005.
111. Chen, S.-H., Sung, W.-C., Lee, G.-B., Lin, Z.-Y., Chen, P.-W., Liao, P.-C., A disposable poly(methylmethacrylate)-based microfluidic module for protein identification by nanoelectrospray ionization-tandem mass spectrometry, Electrophoresis, 22, 3972-3977, 2001.
112. Lazar, I.M., Karger, B.L., Multiple open-channel electroosmotic pumping system for microfluidic sample handling, Anal. Chem., 74, 6259-6268, 2002.
113. Lazar, I.M., Trisiripisal, P., Sarvaiya, H., Microfluidic liquid chromatography system for proteomic applications and biomarker screening, Anal. Chem., 78, 5513-5524, 2006.
114. Yue, G.E., Roper, M.G., Jeffery, E.D., Easley, C.J., Balchunas, C., Landers, J.P., Ferrance, J.P., Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry, Lab Chip, 5, 619-627, 2005.
115. Wachs, T., Henion, J., Electrospray device for coupling microscale separations and other miniaturized devices with electrospray mass spectrometry, Anal. Chem., 73, 632-638, 2001.
116. Deng, Y.Z., Zhang, N.W., Henion, J., Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma, Anal. Chem., 73, 1432-1439, 2001.
117. Deng, Y.Z., Henion, J., Li, J.J., Thibault, P., Wang, C., Harrison, D.J., Chip-based capillary electrophoresis/mass spectrometry determination of carnitines in human urine, Anal. Chem., 73, 639-646, 2001.
118. Wang, G.-J, Yang, M.-W., Chang, Y.-Z., Dead volume free micro-machined electro-spray chip for mass spectrometry, Biomed. Microdev., 6, 159-164, 2004.
119. Schultz, G.A., Corso, T.N., Prosser, S.J., Zhang, S., A fully integrated monolithic microchip electrospray device for mass spectrometry, Anal. Chem., 72, 4058-4063, 2000.
120. Dethy, J.-M., Ackerman, B.L., Delatour, C., Henion, J.D., Schultz, G.A., Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry, Anal. Chem., 75, 4058-4063, 2003.
121. Griss, P., Melin, J., Sjodahl, J., Roeraade, J., Stemme, G., Development of micromachined hollow tips for protein analysis based on nanoelectrospray ionization mass spectrometry, J. Micromech. Microeng., 12, 682-687, 2002.
122. Sjödahl, J., Melin, J., Griss, P., Emmer, L., Stemme, G., Roeraade, J., Characterization of micromachined hollow tips for two-dimensional nanoelectrospray mass spectrometry, Rapid Commun. Mass Spectrom., 17, 337-341, 2003.
123. Arscott, S., Le Gac, S., Rolando, C., A polysilicon nanoelectrospray-mass spectrometry source based on a capillary microfluidic slot, Sens. Actuat. B, 106, 741-749, 2005.
124. Licklider, L., Wang, X.Q., Desai, A., Tai, Y.C., Lee, T.D., A micromachined chip-based electrospray source for mass spectrometry, Anal. Chem., 72, 367-375, 2000.
125. Xie, J., Miao, Y., Shih, J., He, Q., Liu, J., Tai, Y.-C., Lee, T.D., An electrochemical pumping system for on-chip gradient generation, Anal. Chem., 76, 3756-3763, 2004.
126. Xie, J., Miao, Y., Shih, J., Tai, Y.-C., Lee, T.D., Microfluidic platform for liquid chromatographytandem mass spectrometry analysis of complex peptide mixtures, Anal. Chem., 77, 6947-6953, 2005.
127. Kameoka, J., Orth, R., Ilic, B., Czaplewski, D., Wachs, T., Craighead, H.G., An electrospray ionization source for integration with microfluidics, Anal. Chem., 74, 5897-5901, 2002.
128. Ek, P., Sjödahl, J., Roeraade, J., Electrospray ionization from a gap with adjustable width, Rapid Commun. Mass Spectrom., 20, 3176-3182, 2006.
129. Gobry, V., van Oostrum, J., Martinelli, M., Rohner, T.C., Reymond, F., Rossier, J.S., Girault, H.H., Microfabricated polymer injector for direct mass spectrometry coupling, Proteomics, 2, 405-412, 2002.
130. Lion, N., Gellon, J.O., Girault, H.H., Flow-rate characterization of microfabricated polymer microspray emitters, Rapid Commun. Mass Spectrom., 18, 1614-1620, 2004.
131. Yin, H., Killeen, K., Brennen, R., Sobek, D., Werlich, M., van de Goor, T., Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip, Anal. Chem., 77, 527-533, 2005.
132. Fortier, M.-H., Bonneil, E., Goodley, P., Thibault, P., Integrated microfluidic device for mass spectrometry-based proteomics and its application to biomarker discovery programs, Anal. Chem., 77, 1631-1640, 2005.
133. Hardoiun, J., Duchateau, M., Joubert-Caron, R., Caron, M., Usefulness of an integrated microfluidic device (HPLC-Chip-MS) to enhance confidence in protein identification by proteomics, Rapid Commun. Mass Spectrom., 20, 3236-3244, 2006.
134. Tang, K., Lin, Y., Matson, D.W., Kim, T., Smith R.D., Generation of multiple electrosprays using microfabricated emitter arrays for improved mass spectrometric sensitivity, Anal. Chem., 73, 1658-1663, 2001.
135. Svedberg, M., Pettersson, A., Nilsson, S., Bergquist, J., Nyholm, L., Nikolajeff, F., Markides, K., Sheathless electrospray from polymer microchips, Anal. Chem., 75, 3934-3940, 2003.
136. Muck, A., Svatos, A., Atmospheric molded poly(methylmethacrylate) microchip emitters for sheathless electrospray, Rapid Commun. Mass Spectrom., 18, 1459-1464, 2004.
137. Schilling, M., Nigge, W., Rudzinski, A., Neyer, A., Hergenroder, R., A new on-chip ESI nozzle for coupling of MS with microfluidic devices, Lab Chip, 4, 220-224, 2004.
138. Yuan, C.-H., Shiea, J., Sequential electrospray analysis using sharp-tip channels fabricated on a plastic chip, Anal. Chem., 73, 1080-1083, 2001.
139. Kim, J.-S., Knapp, D.R., Microfabrication of polydimethylsiloxane electrospray ionization emitters, J. Chromatogr. A, 924, 137-145, 2001.
140. Kim, J.-S., Knapp, D.R., MicrofabricatedPDMSmultichannel emitter for electrospray ionization mass spectrometry, J. Am. Soc. Mass. Spectrom., 12, 463-469, 2001.
141. Kim, J.-S., Knapp, D.R., Miniaturized multichannel electrospray ionization emitters on poly(dimethylsiloxane) microfluidic devices, Electrophoresis, 22, 3993-3999, 2001.
142. Chiou, C.H., Lee, G.B., Hsu, H.T., Chen, P.W., Liao, P.C., Micro devices integrated with microchannels and electrospray nozzles using PDMS casting techniques, Sens. Actuat. B, 86, 280-286, 2002.
143. Iannacone, J.M., Jacubowski, J.A., Bohn, P.W., Sweedler, J.V., A multilayer poly(dimethylsiloxane) electrospray ionization emitter for sample injection and online mass spectrometric detection, Electrophoresis, 26, 4684-4690, 2005.
144. Svedberg, M., Veszelei, M., Axelsson, J., Vangbo, M., Nikolajeff, F., Poly(dimethylsiloxane) microchip: microchannel with integrated open electrospray tip, Lab Chip, 4, 322-327, 2004.
145. Liljegren, G., Dahlin, A., Zettersten, C., Bergquist, J., Nyholm, L., On-line coupling of a microelectrode array equipped poly(dimethylsiloxane) microchip with an integrated graphite electrospray emitter for electrospray ionization mass spectrometry, Lab Chip, 5, 1008-1016, 2005.
146. Thorslund, S., Lindberg, P., Andrén P.E., Nikolajeff, F., Bergquist, J., Electrokinetic-driven microfluidic system in poly(dimethylsiloxane) for mass spectrometry detection integrating sample injection, capillary electrophoresis, and electrospray emitter on-chip, Electrophoresis, 26, 4674-4678, 2005.
147. Le Gac, S., Arscott, S., Rolando, C., Aplanar microfabricated nanoelectrospray emitter tip based on a capillary slot, Electrophoresis, 24, 3640-3647, 2003.
148. Le Gac, S., Arscott, S., Cren-Olivé, C., Rolando, C., Two-dimensional microfabricated sources for nanoelectrospray, J. Mass Spectrom., 38, 1259-1264, 2003.
149. Arscott, S, Le Gac, S., Druon, C., Tabourier, P., Rolando, C., Amicro-nib nanoelectrospray source for mass spectrometry, Sens. Actuat. B, 98, 140-147, 2004.
150. Arscott, S, Le Gac, S., Druon, C., Tabourier, P., Rolando, C., A planar on-chip micro-nib interface for nanoESI-MS microfluidic applications, J. Micromech. Microeng., 14, 310-316, 2004.
151. Carlier, J., Arscott, S., Thomy, V., Camart, J.-C., Cren-Olivé, C., Le Gac, S., Integrated microfabricated systems including a purification module and an on-chip nano electrospray ionization interface for biological analysis, J. Chromatogr. A, 1071, 213-222, 2005.
152. Tuomikoski, S., Sikanen, T., Ketola, R.A., Kostiainen, R., Kotiaho, T., Franssila, S., Fabrication of enclosed SU-8 tips for electrospray ionization-mass spectrometry, Electrophoresis, 26, 4691-4702, 2005.
153. Bedair, M.F., Oleschuk, R.D., Fabrication of porous polymer monoliths in polymeric microfluidic chips as an electrospray emitter for direct coupling to mass spectrometry, Anal. Chem., 78, 1130-1138, 2006.
154. Peterson, D.S., Rohr, T., Svec, F., Fréchet, J.M.J., Dual-function microanalytical device by in situ photolithographic grafting of porous polymer monolith: Integrating solid-phase extraction and enzymatic digestion for peptide mass mapping, Anal. Chem., 75, 5328-5335, 2003.
155. Önnerfjord, P., Nilsson, J., Wallman, L., Laurell, T., Marko-Varga, G., Picoliter sample preparation in MALDI-TOF MS using micromachined silicon flow-through dispenser, Anal. Chem., 70, 4755-4760, 1998.
156. Musiyimi, H.K., Guy, J., Narcisse, D.A., Soper, S.A., Murray, K.K., Direct coupling of polymerbased microchip electrophoresis to on-line MALDI-MS using a rotating ball inlet, Electrophoresis, 26, 4703-4710, 2005.
157. Miliotis, T., Kjellstrom, S., Nilsson, J., Laurell, T., Edholm, L.E., Marko-Varga, G., Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser, J. Mass Spectrom., 35, 369-377, 2000.
158. Laurell, T., Wallman, L., Nilsson, J., Design and development of a silicon microfabricated flow-through dispenser for on-line picoliter sample handling, J. Micromech. Microeng., 9, 369-376, 1999.
159. Laurell, T., Nilsson, J., Marko-Varga, G., Silicon microstructures for high-speed and high-sensitivity protein identifications, J. Chromatogr. B, 752, 217-232, 2001.
160. Laurell, T., Marko-Varga, G., Ekström, S., Bengtsson, M., Nilsson J, Microfluidic components for protein characterization, Rev. Mol. Biotechnol., 82, 161-175, 2001.
161. Krone, J.R., Nelson, R.W., Dogruel, D., Williams, P., Granzow, R., BIA/MS: interfacing biomolecular interaction analysis with mass spectrometry, Anal. Biochem., 244, 124-132, 1997.
162. Sönksen, C.P., Nordhoff, E., Jansson, Ö., Malmqvist, M., Roepstorff, P., Combining MALDI mass spectrometry and biomolecular interaction analysis using a biomolecular interaction analysis instrument, Anal. Chem., 70, 2731-2736, 1998.
163. Gilligan, J.J., Schuck, P., Yergey, A.L., Mass spectrometry after capture and small-volume elution of analyte from a surface plasmon resonance biosensor, Anal. Chem., 74, 2041-2047, 2002.
164. Borch, J., Roepstorff, P., Screening for enzyme inhibitors by surface plasmon resonance combined with mass spectrometry, Anal. Chem., 76, 5243-5248, 2004.
165. Natsume, T., Nakayama, H., Jansson, Ö., Isobe, T., Takio, K., Mikoshiba, K., Combination of biomolecular interaction analysis and mass spectrometric amino acid sequencing, Anal. Chem., 72, 4193-4198, 2000.
166. Sydor, J.R., Scalf, M., Sideris, S., Mao, G.D., Pandey, Y., Tan, M., Mariano, M., Moran, M.F., Nock, S., Wagner, P., Chip-based analysis of protein-protein interactions by fluorescence detection and on-chip immunoprecipitation combined with µLC-MS/MS analysis, Anal. Chem., 75, 6163-6170, 2003.
167. Grote, J., Dankbar, N., Gedig, E., Koenig, S., Surface plasmon resonance/mass spectrometry interface, Anal. Chem., 77, 1157-1162, 2005.
168. Whelan, R.J., Zare, R.N., Surface plasmon resonance detection for capillary electrophoresis separations, Anal. Chem., 75, 1542-1547, 2003.
169. Liu, J., Tseng, K., Garcia, B., Lebrilla, C.B., Mukerjee, E., Collins, S., Smith, R., Electrophoresis separation in open microchannels. A method for coupling electrophoresis with MALDI-MS, Anal. Chem., 73, 2147-2151, 2001.
170. Mok, M.L.-S., Hua, L., Phua, J.B.-C., Wee, M.K.-T., Sze, N.S.-K., Capillary isoelectric focusing in pseudo-closed channel coupled to matrix assisted laser desorption/ionization mass spectrometry for protein analysis, Analyst, 129, 109-110, 2004.
171. Guo, X., Chan-Park, M.B., Yoon, S.F., Chun, J.-H., Hua, L., Sze, N.S.-K., UV embossed polymeric chip for protein separation and identification based on capillary isoelectric focusing and MALDI-TOFMS, Anal. Chem., 78, 3249-3256, 2006.
172. Brivio, M., Fokkens, R.H., Verboom, W., Reinhoudt, D.N., Tas, N.R., Goedbloed, M., van den Berg, A., Integrated microfluidic system enabling (bio)chemical reactions with on-line MALDI-TOF mass spectrometry, Anal. Chem., 74, 3972-3976, 2002.
173. Brivio, M., Tas, N.R., Goedbloed M.H., Gardeniers, H.J.G.E., Verboom, W., Reinhoudt D.N., van den Berg, A., A MALDI chip integrated system with a monitoring window, Lab Chip, 5, 378-381, 2005.
174. Sim, T.S., Kim, E.-M., Joo, H.S., Kim, B.G., Kim Y.-K., Application of a temperature-controllable microreactor to simple and rapid protein identification using MALDI-TOF MS, Lab Chip, 6, 1056-1061, 2006.
175. Gustafsson, M., Hirschberg, D., Palmberg, C., Jornvall, H., Bergman, T., Integrated sample preparation and MALDI mass spectrometry on a microfluidic compact disk, Anal. Chem., 76, 345-350, 2004.
176. Hirschberg, D., Jagerbrink, T., Samskog, J., Gustafsson, M., Stahlberg, M., Alvelius, G., Husman, B., Carlquist, M., Jornvall, H., Bergman, T., Detection of phosphorylated peptides in proteomic analyses using microfluidic compact disk technology, Anal. Chem., 76, 5864-5871, 2004.
177. Wheeler, A.R., Moon, H., Kim, C.-J., Loo, J.A., Garrell, R.L., Electrowetting-based microfluidics for analysis of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry, Anal. Chem., 76, 4833-4838, 2004.
178. Wheeler, A.R., Moon, H., Bird, C.A., Loo, R.R.O., Kim, C.-J., Loo, J.A., Garrell, R.L., Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS, Anal. Chem., 77, 534-540, 2005.
179. Moon, H., Wheeler, A.R., Garrell, R.L., Loo, J.A., Kim, C.-J., An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS, Lab Chip, 6, 1213-1219, 2006.
180. Ekström, S., Onnerfjord, P., Nilsson, J., Bengtsson, M., Laurell, T., Marko-Varga, G., Integrated microanalytical technology enabling rapid and automated protein identification, Anal. Chem., 72, 286-293, 2000.
181. Ekström, S., Ericsson, D., Onnerfjord, P., Bengtsson, M., Nilsson, J., Marko-Varga, G., Laurell, T., Signal amplification using “spot on-a-chip” technology for the identification of proteins via MALDITOF MS, Anal. Chem., 73, 214-219, 2001.
182. Laurell, T., Nilsson, J., Marko-Varga, G., Proteomics-protein profiling technology: the trend towards a microfabricated toolbox concept, Trends Anal. Chem., 20, 225-231, 2001.
183. Marko-Varga, G., Ekström, S., Helldin, G., Nilsson, J., Laurell, T., Disposable polymeric high-density nanovial arrays for matrix assisted laser desorption ionization-time-of-flight mass spectrometry: I. Microstructure development and manufacturing, Electrophoresis, 22, 3978-3983, 2001.
184. Ekström, S., Nilsson, J., Helldin, G., Laurell, T., Marko-Varga, G., Disposable polymeric high-density nanovial arrays for matrix assisted laser desorption ionization-time-of-flight mass spectrometry: I. Biological applications, Electrophoresis, 22, 3984-3992, 2001.
185. Ekström, S., Wallman, L., Malm, J., Becker, C., Lilja, H., Laurell, T., Marko-Varga, G., Integrated selective enrichment target-a microtechnology platform for matrix assisted laser desorption ionizationmass spectrometry applied on protein biomarkers in prostate diseases, Electrophoresis, 25, 3769-3777, 2004.
186. Berhane, T., Limbach, P.A., Functional microfabricated sample targets for matrix-assisted laser desorption/ionization mass spectrometry analysis of ribonucleic acids, Anal. Chem., 75, 1997-2003, 2003.
187. Sjödahl, J., Kempka, M., Hermansson, K., Thorsén, A., Roeraade, J., Chip with twin anchors for reduced ion suppression and improved mass accuracy in MALDI-TOF mass spectrometry, Anal. Chem., 77, 827-832, 2005.
188. Östman, P., Jäntti, S., Grigoras, K., Saarela, V., Ketola, R. A., Franssila, S., Kotiaho, T., Kostiainen, R., Capillary liquid chromatography-microchip atmospheric pressure chemical ionization-mass spectrometry, Lab Chip, 6, 948-953, 2006.
189. Petricoin, E.F., III, Ardekani, A.M., Hitt, B.A., Levine, P.J., Fusaro, V.A., Steinberg, S.M., Mills, G.B., Simone, C., Fishman, D.A., Kohn, E.C., Liotta, L.A., Use of proteomic patterns in serum to identify ovarian cancer, Lancet, 359, 572-577, 2002.
190. Borrebaeck, C.A.K., Ekström, S., Malmborg Hager, A.C., Nilsson, J., Laurell, T., Marko-Varga, G., Protein chips based on recombinant antibody fragments: a highly sensitive approach as detected by mass spectrometry, Biotechniques, 30, 1126-1131, 2001.
191. Finnskog, D., Ressine, A., Laurell, T., Marko-Varga, G., Integrated protein microchip assay with dual fluorescent- and MALDI read-out, J. Proteome Res., 3, 988-994, 2004.
192. Diamandis, E.P., Mass spectrometry as a diagnostic and cancer biomarker discovery tool, Mol. Cell. Proteomics, 3, 367-378, 2004.
193. Tang, N., Tornatore, P., Weinberger, S.R., Current developments in SELDI affinity technology, Mass Spectrom. Rev., 23, 34-44, 2004.
194. Sunner, J., Dratz, E., Chen, Y.-C., Graphite surface-assisted laser desorption ionization time-of-flight mass spectrometry of peptides and proteins from liquid solutions, Anal. Chem., 67, 4335-4342, 1995.
195. Chen, Y.-C., Shiea, J., Sunner, J., Thin-layer chromatography-mass spectrometry using activated carbon, surface-assisted laser desorption/ionization, J. Chromatogr. A, 826, 77-86, 1998.
196. Wei, J., Buriak, J.M., Siuzdak, G., Desorption-ionization mass spectrometry on porous silicon, Nature, 399, 243-246, 1999.
197. Finkel, N.H., Prevo, B.G., Velev, O.D., He, L., Ordered silicon nanocavity arrays in surface-assisted desorption/ionization mass spectrometry, Anal. Chem., 77, 1088-1095, 2005.
198. Zhang, S., Van Pelt, C.K., Henion, J.D., Automated chip-based nanoelectrospray-mass spectrometry for rapid identification of proteins separated by two-dimensional gel electrophoresis, Electrophoresis, 24, 3620-3632, 2003.
199. Zhang, S., Chelius, D., Characterization of protein glycosylation using chip-based infusion nanoelectrospray linear ion trap tandem mass spectrometry, J. Biomol. Tech., 15,120-133, 2004.
200. Zamfir, A., Vakhrushev, S., Sterling, A., Niebel, H.J., Allen, M., Peter-Katalinic, J., Fully automated chip-based mass spectrometry for complex carbohydrate system analysis, Anal. Chem., 76, 2046-2054, 2004.
201. Zamfir, A.D., Lion, N., Vukelić, Ž., Bindilla, L., Rossier, J., Girault, H.H., Peter-Katalinic, J., Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis, Lab Chip, 5, 298-307, 2005.
202. Leuthold, L.A., Grivet, C., Allen, M., Baumert, M., Hopfgartner, G., Simultaneous selected reaction monitoring, MS/MS and MS3 quantitation for the analysis of pharmaceutical compounds in human plasma using chip-based infusion, Rapid Commun. Mass Spectrom., 18, 1995-2000, 2004.
203. Kapron, J.T., Pace, E., Van Pelt, C.K., Henion, J., Quantitation of midazolam in human plasma by automated chip-based infusion nanoelectrospray tandem mass spectrometry, Rapid Commun. Mass Spectrom., 17, 2019-2026, 2003.
204. Xiang, F., Lin, Y., Wen, J., Matson, D.W., Smith, R.D., An integrated microfabricated device for dual microdialysis and on-line ESI ion trap mass spectrometry for analysis of complex biological samples, Anal. Chem., 71, 1485-1490, 1999.
205. Lion, N., Gobry, V., Jensen, H., Rossier, J.S., Girault, H., Integration of a membrane-based desalting step in a microfabricated disposable polymer injector for mass spectrometric protein analysis, Electrophoresis, 23, 3583-3588, 2002.
206. Lion, N., Gellon, J.O., Jensen, H., Girault, H.H., On-chip protein sample desalting and preparation for direct coupling with electrospray ionization mass spectrometry, J. Chromatogr. A, 1003, 11-19, 2003.
207. Le Gac, S., Carlier, J., Camart, J.-C., Cren-Olivé, C., Rolando, C., Monoliths for microfluidic devices and proteomics, J. Chromatogr. B, 808, 3-14, 2004.
208. Wilson, D.J., Konermann, L., Ultrarapid desalting of protein solutions for electrospray mass spectrometry in a microchannel flow device, Anal. Chem., 77, 6887-6894, 2005.
209. Bergkvist, J., Ekström, S., Wallman, L., Löfgren, M., Marko-Varga, G., Nilsson, J., Laurell, T., Improved chip design for integrated solid-phase microextraction in on-line proteomic sample preparation, Proteomics, 2, 422-429, 2002.
210. Ekström, S., Malmström, J., Wallman, L., Löfgren, M., Nilsson, J., Laurell, T., Marko-Varga, G., On-chip microextraction for proteomic sample preparation of in-gel digests. Proteomics, 2, 413-421, 2002.
211. Wallman, L., Ekström, S., Marko-Varga, G., Laurell, T., Nilsson, J., Autonomous protein sample processing on-chip using solid-phase microextraction, capillary force pumping, and microdispensing, Electrophoresis, 25, 3778-3787, 2004.
212. Yu, C., Davey, M.H., Svec, F., Fréchet, J.M.J., Monolithic porous polymer for on-chip solidphase microextraction and preconcentration prepared by photoinitiated in situ polymerization within a microfluidic device, Anal. Chem., 73, 5088-5096, 2001.
213. Tan, A., Benetton, S., Henion, J.D., Chip-based solid-phase extraction pre-treatment for direct electrospray mass spectrometry analysis using an array of monolithic columns in a polymeric substrate, Anal. Chem., 75, 5504-5511, 2003.
214. Li, C., Lee, K.H., Affinity depletion of albumin from human cerebrospinal fluid using Cibacron-blue-3G-A-derivatized photopatterned copolymer in a microfluidic device, Anal. Biochem., 333, 381-388, 2004.
215. Jiang, Y., Wang, P.-C., Locascio, L.E., Lee, C.S., Integrated plastic microfluidic devices with ESI-MS for drug screening and residue analysis, Anal. Chem., 73, 2048-2053, 2001.
216. Li, J., LeRiche, T., Tremblay, T.L., Wang, C., Bonneil, E., Harrison, D.J., Thibault, P., Application of microfluidic devices to proteomics research - Identification of trace-level protein digests and affinity capture of target peptides, Mol. Cel. Proteomics, 1, 157-168, 2002.
217. Wang, C., Oleschuk, R., Ouchen, F., Li, J.J., Thibault, P., Harrison, D.J., Integration of immobilized trypsin bead beds for protein digestion within a microfluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface, Rapid Commun. Mass Spectrom., 14, 1377-1383, 2000.
218. Jin, L.J., Ferrance, J., Sanders, J.C., Landers, J.P., A microchip-based proteolytic digestion system driven by electroosmotic pumping, Lab Chip, 3, 11-18, 2003.
219. Gao, J., Xu, J., Locascio, L.E., Lee, C.S., Integrated microfluidic system enabling protein digestion, peptide separation, and protein identification, Anal. Chem., 73, 2648-2655, 2001.
220. Lazar, I.M., Ramsey, R.S., Ramsey, J.M., On-chip proteolytic digestion and analysis using “wrongway- round” electrospray time-of-flight mass spectrometry, Anal. Chem., 73, 1733-1739, 2001.
221. Bengtsson, M., Ekström, S., Marko-Varga, G., Laurell, T., Improved performance in silicon enzyme microreactors obtained by homogeneous porous silicon carrier matrix, Talanta, 56, 341-353, 2002.
222. Melander, C., Momcilovic, D., Nilsson, C., Bengtsson, M., Schagerlöf, H., Tjerneld, F., Laurell, T., Reimann, C.T., Gorton, L., Microchip immobilized enzyme reactors for hydrolysis of methyl cellulose, Anal. Chem., 77, 3284-3291, 2005.
223. Liu, Y., Lu, H., Zhong, W., Song, P., Kong, J., Yang, P., Girault, H.H., Liu, B., Multilayer-assembled microchip for enzyme immobilization as reactor toward low-level protein identification, Anal. Chem., 78, 801-808, 2006.
224. De Boer, A.R., Bruyneel, B., Krabbe, JG., Lingeman, H., Niessen, W.M.A., Irth, H., A microfluidicbased enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry, Lab Chip, 5, 1286-1292, 2005.
225. Foret, F., Zhou, H.H., Gangl, E., Karger, B.L., Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry, Electrophoresis, 21, 1363-1371, 2000.
226. Li, J., Wang, C., Kelly, J.F., Harrison, D.J., Thibault, P., Rapid and sensitive separation of trace level protein digests using microfabricated devices coupled to a quadrupole-time-of-flight mass spectrometer, Electrophoresis, 21, 198-210, 2000.
227. Li, J., Tremblay, T.-L., Wang, C., Attiya, S., Harrison, D.J., Thibault, P., Integrated system for high-throughput protein identification using a microfabricated device coupled to capillary electrophoresis/nanoelectrospray mass spectrometry, Proteomics, 1, 975-986, 2001.
228. Dahlin, A.P., Bergström, S.K., Andrén, P.E., Markides, K.E., Bergquist, J., Poly(dimethylsiloxane)- based microchip for two-dimensional solid-phase extraction-capillary electrophoresis with an integrated electrospray emitter tip, Anal. Chem., 77, 5356-5363, 2005.
229. Kameoka, J., Craighead, H.G., Zhang, H., Henion J., A polymeric microfluidic chip for CE/MS determination of small molecules, Anal. Chem., 73, 1935-1941, 2001.
230. Wen, J., Lin, Y.H., Xiang, F., Matson, D.W., Udseth, H.R., Smith, R.D., Microfabricated isoelectric focusing device for direct electrospray ionization-mass spectrometry, Electrophoresis, 21, 191-197, 2000.
231. Hilder, E.F., Svec, F., Fréchet, J.M.J., Polymeric monolithic stationary phases for capillary electrochromatography, Electrophoresis, 23, 3934-3953, 2002.
232. McEnery, M., Tan, A.M., Alderman, J., Patterson, J., O’Mathuna, S.C., Glennon, J.D., Liquid chromatography on-chip: progression towards a µ-total analysis system, Analyst, 125, 25-27, 1999.
233. Reichmuth, D.S., Shepodd, T.J., Kirby, B.J., Microchip HPLC of peptides and proteins, Anal. Chem., 77, 2997-3000, 2005.
234. Keetch, C.A., Hernandez, H., Sterling, A., Baumert, M., Allen, M.H., Robinson, C.V., Use of a microchip device coupled with mass spectrometry for ligand screening of a multi-protein target, Anal. Chem., 75, 4937-4941, 2003.
235. Zhang, B.L., Foret, F., Karger, B.L., High-throughput microfabricated CE/ESI-MS: automated sampling from a microwell plate, Anal. Chem., 73, 2675-2681, 2001.
236. Haber, C., Microfluidics in commercial applications, an industry perspective, Lab Chip, 6, 1118-1121, 2006.