Premature senescence of T cells in long-term survivors of renal transplantation

Biochemical and Biophysical Research Communications

Volumn 407, Issue 3, 2011, Pages 599-604

  Li, Ping ^a,c   Tian, Chuan ^a   Ge, Nan ^a   Wang, Hongwei ^a   Liu, Li ^b   Lou, Fenglan ^a   Björkholm, Magnus ^c   Xu, Dawei ^a,c  

^a SHANDONG UNIVERSITY   (China)

^b Blood Center of Shandong Province   (China)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

HTERT; Immunosenescence; Renal transplantation; T cell; Telomerase; Telomere

Indexed keywords

AZATHIOPRINE; CONCANAVALIN A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOSPORIN A; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GRAFT SURVIVAL; HUMAN; HUMAN CELL; KIDNEY TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; T LYMPHOCYTE; TELOMERE; UPREGULATION;

ADULT; AGED; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; SURVIVORS; T-LYMPHOCYTES; TELOMERASE; TELOMERE;

EID: 79954613616     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.079     Document Type: Article

References (26)

1. Nickel P., Bestard O., Volk H.D., et al. Diagnostic value of T-cell monitoring assays in kidney transplantation. Curr. Opin. Organ Transplant. 2009, 14:426-431.
2. Veroux M., Corona D., Veroux P. Kidney transplantation: future challenges. Minerva Chir. 2009, 64:75-100.
3. Naesens M., Sarwal M.M. Molecular diagnostics in transplantation. Nat. Rev. Nephrol. 2010, 6:614-628.
4. Babel N., Reinke P., Volk H.D. Lymphocyte markers and prediction of long-term renal allograft acceptance. Curr. Opin. Nephrol. Hypertens. 2009, 18:489-494.
5. Rama I., Grinyo J.M. Malignancy after renal transplantation: the role of immunosuppression. Nat. Rev. Nephrol. 2010, 6:511-519.
6. Maue A.C., Yager E.J., Swain S.L., et al. T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol. 2009, 30:301-305.
7. Gruver A.L., Hudson L.L., Sempowski G.D. Immunosenescence of ageing. J. Pathol. 2007, 211:144-156.
8. Pawelec G., Derhovanessian E., Larbi A. Immunosenescence and cancer. Crit. Rev. Oncol. Hematol. 2010, 75:165-172.
9. Pawelec G., Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2010, 10.1016/j.virusres.2010.09.010.
10. Effros R.B. Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress. Exp. Gerontol. 2010, 46:135-140.
11. Gharagozloo M., Bagherpour B., Tahanian M., et al. Premature senescence of T lymphocytes from patients with beta-thalassemia major. Immunol. Lett. 2009, 122:84-88.
12. Fletcher J.M., Vukmanovic-Stejic M., Dunne P.J., et al. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J. Immunol. 2005, 175:8218-8225.
13. Kaszubowska L. Telomere shortening and ageing of the immune system. J. Physiol. Pharmacol. 2009, 59(Suppl. 9):169-186.
14. Weng N.P. Telomere and adaptive immunity. Mech. Ageing Dev. 2008, 129:60-66.
15. Cawthon R.M. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002, 30:e47.
16. Strååt K., Liu C., Rahbar A., et al. Activation of telomerase by human cytomegalovirus. J. Natl. Cancer Inst. 2009, 101:488-497.
17. Shay J.W., Wright W.E. Hallmarks of telomeres in ageing research. J. Pathol. 2007, 211:114-123.
18. Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106:661-673.
19. Liu J.P., Chen S.M., Cong Y.S., et al. Regulation of telomerase activity by apparently opposing elements. Ageing Res. Rev. 2010, 9:245-256.
20. Liu L., Lai S., Andrews L.G., et al. Genetic and epigenetic modulation of telomerase activity in development and disease. Gene 2004, 340:1-10.
21. Jalink M., Ge Z., Liu C., et al. Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA. Biochem. Biophys. Res. Commun. 2007, 353:999-1003.
22. Ge Z., Liu C., Bjorkholm M., et al. Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. Mol. Cell. Biol. 2006, 26:230-237.
23. Haynes L., Maue A.C. Effects of aging on T cell function. Curr. Opin. Immunol. 2009, 21:414-417.
24. Harley C.B., Liu W., Blasco M., et al. A natural product telomerase activator as part of a health maintenance program. Rejuvenation Res. 2010, 10.1089/rej.2010.1085.
25. Chebel A., Rouault J.P., Urbanowicz I., et al. Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. J. Biol. Chem. 2009, 284:35725-35734.
26. Liu Y., Johnson S.M., Fedoriw Y., et al. Expression of p16INK4a prevents cancer and promotes aging in lymphocytes. Blood 2010, 10.1182/blood-2010-09-304402.