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Predominant Th 1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy
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This study demonstrates the role of T-cell mediated inflammatory/ cytotoxic processes in the pathogenesis of transplant glomerulopathy.
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Homs S, Mansour H, Desvaux D, et al. Predominant Th 1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy. Am J Transplant 2009; 9:1230-1236. This study demonstrates the role of T-cell mediated inflammatory/cytotoxic processes in the pathogenesis of transplant glomerulopathy.
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Homs, S.1
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+ T cells with normal immuno-regulatory properties in long-term graft outcome
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Braudeau C, Racape M, Giral M, et al. Variation in numbers of CD4+CD25 high FOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome. Transplant Int 2007; 20:845-855. (Pubitemid 47393535)
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8
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56249146391
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Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change
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This study suggests that Foxp3 mRNA exression is a useful predictive marker of borderline histologic changes in renal transplant patients.
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Mansour H, Homs S, Desvaux D, et al. Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change. J Am Soc Nephrol 2008; 19:2277-2281. This study suggests that Foxp3 mRNA exression is a useful predictive marker of borderline histologic changes in renal transplant patients.
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Mansour, H.1
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Identification of gene markers for the prediction of allograft rejection or permanent acceptance
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A novel role of CD4 Th 17 cells in mediating cardiac allograft rejection and vasculopathy
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Yuan X, Paez-Cortez J, Schmitt-Knosalla I, et al. A novel role of CD4 Th 17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008; 205:3133-3144. This is the first study demonstrating the role of TH 17 in the development of allograft rejection in the absence of Th1 -mediated alloimmunity.
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Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection
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15
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Martínez-Llordella M, Lozano JJ, Puig-Pey I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance In liver transplant recipients. J Clin Invest 2008; 118:2845-2857. The data of the study demonstrate transcriptional profiling of peripheral blood that can be employed to identify liver transplant recipients appropriate for the discontinuation of immunosuppressive therapy.
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J Clin Invest
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19
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21
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This study applied a previously established transcriptional profile using 11 distinct genes for prediction of cardiac allograft rejection weeks to months prior to the actual event. The authors were able to separate patients early after transplantation into low-risk, intermediate-risk or high-risk categories for future rejection.
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This study applied a previously established transcriptional profile using 11 distinct genes for prediction of cardiac allograft rejection weeks to months prior to the actual event. The authors were able to separate patients early after transplantation into low-risk, intermediate-risk or high-risk categories for future rejection.
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22
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23
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74549203968
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This study demonstrates a unique peripheral blood mononuclear cell gene signature associated with human operational tolerance In kidney transplant patients using the expression pattern of 343 genes.
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This study demonstrates a unique peripheral blood mononuclear cell gene signature associated with human operational tolerance In kidney transplant patients using the expression pattern of 343 genes.
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24
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34249052267
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Nickel P, Presber F, Bold G, et al. Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-produclng cells identifies T-cell presensituation and correlates with graft function at 6 and 12 months in renaltransplant recipients. Transplantation 2004; 78:1640-1646. (Pubitemid 39648437)
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This study demonstrates for the first time that circulating donor-specific alloreactive T cells primed by direct and indirect allorecognition pathways are detectable long after transplantation and are associated with graft injury.
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This study demonstrates for the first time that circulating donor-specific alloreactive T cells primed by direct and indirect allorecognition pathways are detectable long after transplantation and are associated with graft injury.
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35
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34248357387
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Augustine JJ, Poggio ED, Clemente M, et al. Hemodialysis vintage, black ethnicity, and pretransplantation antidonor cellular immunity in kidney transplant recipients. J Am Soc Nephrol 2007; 18:1602-1606. (Pubitemid 46729200)
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The data of the study showed that HLA class I mismatches, total HLA mismatches, pretransplant HLA-donor specific antibodies as well as higher pretransplant iATP levels were associated with biopsy-proven acute rejection
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Reinsmoen NL, Cornett KMM, Kloehn R, et al. Pretransplant donor-specific and nonspecific immune parameters associated with early acute rejection. Transplantation 2008; 85:462-470. The data of the study showed that HLA class I mismatches, total HLA mismatches, pretransplant HLA-donor specific antibodies as well as higher pretransplant iATP levels were associated with biopsy-proven acute rejection.
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