A multicenter, double-blind, placebo-controlled study of sildenafil citrate in Canadian men with erectile dysfunction and untreated symptoms of depression, in the absence of major depressive disorder

International Clinical Psychopharmacology

Volumn 26, Issue 3, 2011, Pages 151-158

  Kennedy, Sidney H ^a   Dugré, Hélène ^b   Defoy, Isabelle ^c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b Hôpital St Luc   (Canada)

^c PFIZER INC   (United States)

Author keywords

depression; dysthymia; erectile dysfunction

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; AGED; ARTICLE; BECK DEPRESSION INVENTORY; CANADA; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; DYSPEPSIA; ERECTILE DYSFUNCTION; HEADACHE; HOT FLUSH; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MULTICENTER STUDY; PREDICTOR VARIABLE; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; RHINITIS; SCREENING; SIDE EFFECT; VASODILATATION;

ANTIDEPRESSIVE AGENTS; CANADA; DEPRESSION; DOUBLE-BLIND METHOD; ERECTILE DYSFUNCTION; HUMANS; MALE; PENILE ERECTION; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; PURINES; SULFONES; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 79954611867     PISSN: 02681315     EISSN: 14735857     Source Type: Journal    
DOI: 10.1097/YIC.0b013e32834309fc     Document Type: Article

References (42)

1. Althof SE (2002). Quality of life and erectile dysfunction. Urology 59:803-810. (Pubitemid 34522164)
2. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders DSM-IV-TR fourth edition (text revision). 4th edition. Washington DC: American Psychiatric Association.
3. Andersson KE, Wagner G (1995). Physiology of penile erection. Physiol Rev 75:191-236.
4. Angst J (1998). Sexual problems in healthy and depressed persons. Int Clin Psychopharmacol 13 (Suppl 6):S1-S4. (Pubitemid 28372344)
5. Araujo AB, Durante R, Feldman HA, Goldstein I, McKinley J (1998). The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psycho-som Med 60:458-465. (Pubitemid 28354846)
6. Beck AT, Steer RA, Ball R, Ranieri W (1996). Comparison of Beck Depression Inventories-IA and II in psychiatric outpatients. J Personality Assess 67:588-597. (Pubitemid 26382973)
7. Bonierbale M, Lançon C, Tignol J (2003). The ELIXIR study: evaluation of sexual dysfunction in 4557 depressed patients in France. Curr Med Res Opin 19:114-124. (Pubitemid 36548126)
8. Bremner WJ, Vitcello MV, Prinz PN (1983). Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 56:1278-1281. (Pubitemid 13055125)
9. Evuarherhe O, Leggett JD, Waite EJ, Kershaw YM, Atkinson HC, Lightman SL (2009). Organizational role for pubertal androgens on adult hypothalamic- pituitary-adrenal sensitivity to testosterone in the male Sprague Dawley rat. J Physiol 587:2977-2985.
10. Fava M, Nurnberg HG, Seidman SN, Holloway W, Nicholas S, Tseng LJ, et al. (2006). Efficacy and safety of sildenafil citrate (viagra) in men with serotonergic antidepressant-associated erectile dysfunction: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 67:240-246. (Pubitemid 43357470)
11. Georgiadis JR, Holstege G (2005). Human brain activation during sexual stimulation of the penis. J Comp Neurol 493:33-38. (Pubitemid 41636183)
12. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (1998). Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 14:1397-1404. (Pubitemid 28221980)
13. Jønler M, Moon T, Brannan W, Stone NN, Heisey D, Bruskewitz RC (1995). The effect of age, ethnicity and geographical location on impotence and quality of life. Br J Urol 75:651-655.
14. Keleta YB, Lumia AR, Anderson GM, McGinnis MY (2007). Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin. Brain Res 1132:129-138. (Pubitemid 46096442)
15. Kennedy SH, Fulton KA, Bagby RM, Greene AL, Cohen NL, Rafi-Tari S (2006). Sexual function during bupropion or paroxetine treatment of major depressive disorder. Can J Psychiatry 51:234-242.
16. Kennedy SH, Rizvi SJ, Fulton K, Ellis J, Quilty LC, Ravindran L (2010). The sex effects scale: pilot validation in a healthy population. Pharmacol Bull 43.
17. Kriegsfeld LJ, Demas GE, Huang PL, Burnett AL, Nelson RJ (1999). Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-). Physiol Behav 67:561-566. (Pubitemid 29488535)
18. Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R (2001). Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 166:569-574. (Pubitemid 32652251)
19. Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF, et al. (2010). Summary of the recommendations on sexual dysfunctions in men. J Sex Med 7:3572-3588.
20. Moreira ED, Glasser DB, Nicolosi A, Duarte FG, Gingell C; GSSAB Investigators' Group (2008). Sexual problems and help-seeking behaviour in adults in the United Kingdom and continental Europe. BJU Int 101: 1005-1011. (Pubitemid 351422562)
21. Nurnberg HG, Hensley P, Lauriello J, Gelenberg A, Fava M (2001a). Sildenafil citrate for the treatment of sexual dysfunction associated with serotonergic reuptake inhibitors. Int J Impot Res 13:S49.
22. Nurnberg HG, Gelenberg A, Hargreave TB, Harrison WM, Siegel RL, Smith MD (2001b). Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors. Am J Psychiatry 158:1926-1928. (Pubitemid 33054792)
23. Nurnberg HG, Hensley PL, Gelenberg AJ, Fava M, Lauriello J, Paine S (2003). Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA 289:56-64. (Pubitemid 36026278)
24. Nurnberg H, Fava M, Gelenberg A, Hensley P, Paine S (2007). Open-label sildenafil treatment of partial and non-responders to double-blind treatment in men with antidepressant-associated sexual dysfunction. Int J Impot Res 19:167-175. (Pubitemid 46340834)
25. Orr G, Seidman SN, Weiser M, Gershon AA, Dubrov Y, Klein DF (2008). An open-label pilot study to evaluate the efficacy of sildenafil citrate in middle-aged men with late-onset dysthymia. J Nerv Ment Dis 196: 496-500.
26. Owens MJ, Nemeroff CB (1994). Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40:288-295. (Pubitemid 24072594)
27. Papiol S, Arias B, Gastó C, Gutié rrez B, Catalán R, Fañanás L (2007). Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J Affect Disord 104:83-90. (Pubitemid 350052308)
28. Phillips RL Jr, Slaughter JR (2000). Depression and sexual desire. Am Fam Physician 62:782-786. (Pubitemid 30655905)
29. Rizvi SJ, Kennedy SH, Ravindran LN, Giacobbe P, Eisfeld BS, Mancini D, McIntyre RS (2010). The relationship between testosterone and sexual function in depressed and healthy men. J Sex Med 7(2 Pt 1): 816-825.
30. Rosen R, Shabsigh R, Berber M, Assalian P, Menza M, Rodriguez-Vela L, et al. (2006). Efficacy and tolerability of vardenafil in men with mild depression and erectile dysfunction: the depression-related improvement with vardenafil for erectile response study. Am J Psychiatry 163:79-87. (Pubitemid 43050107)
31. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A (1997). The International index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49:822-830. (Pubitemid 27246947)
32. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM (1999). Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 11:319-326. (Pubitemid 30052683)
33. Saraiva KL, Silva AK, Wanderley MI, De Araújo AA, De Souza JR, Peixoto CA (2009). Chronic treatment with sildenafil stimulates Leydig cell and testosterone secretion. Int J Exp Pathol 90:454-462.
34. Schweiger U, Deuschle M, Weber B, Körner A, Lammers CH, Schmider J, et al. (1999). Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom Med 61:292-296. (Pubitemid 29249785)
35. Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC (2001). Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry 158:1623-1630. (Pubitemid 32923654)
36. Shabsigh R, Klein LT, Seidman S, Kaplan SA, Lehrhoff BJ, Ritter JS (1998). Increased incidence of depressive symptoms in men with erectile dysfunction. Urology 52:848-852. (Pubitemid 28489716)
37. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 (Suppl 20):22-33; quiz 34-57. (Pubitemid 29001829)
38. Thase ME, Reynolds CF, Glanz LM, Jennings JR, Sewitch DE, Kupfer DJ, et al. (1987). Nocturnal penile tumescence in depressed men. Am J Psychiatry 144:89-92. (Pubitemid 17211777)
39. Thase ME, Reynolds CF, Jennings JR, Frank E, Howell JR, Houck PR, et al. (1988). Nocturnal penile tumescence is diminished in depressed men. Biol Psychiatry 24:33-46.
40. Tignol J, Furlan PM, Gomez-Beneyto M, Opsomer R, Schreiber W, Sweeney M, et al. (2004). Efficacy of sildenafil citrate (viagra) for the treatment of erectile dysfunction in men in remission from depression. Int Clin Psychopharmacol 19:191-199. (Pubitemid 38901646)
41. Yang JC (2004). Functional neuroanatomy in depressed patients with sexual dysfunction: blood oxygenation level dependent functional MR imaging. Korean J Radiol 5:87-95.
42. Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, et al. (2002). Sildenafil (viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33:2675-2680. (Pubitemid 35266440)