Persistent anxiolytic affects after chronic administration of the CRF 1 receptor antagonist R121919 in rats

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1135-1141

  Gutman, David A ^a   Owens, Michael J ^b   Thrivikraman, K V ^b   Nemeroff, Charles B ^c  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Animal models; CRF; CRF antagonist; CRH; NBI 30775; R121919

Indexed keywords

3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; MESSENGER RNA;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NUCLEUS (AMYGDALA); CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LATENT PERIOD; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; ORGAN SIZE; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY; WEIGHT GAIN; AMYGDALOID NUCLEUS; ANIMAL MODEL; AREA UNDER THE CURVE; BRAIN REGION; DEFENSIVE BEHAVIOR; DRUG RECEPTOR BINDING; EX VIVO STUDY; RECEPTOR BLOCKING; STARTLE REFLEX; STRESS; TREATMENT OUTCOME; UPREGULATION;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; HYDROCORTISONE; MALE; MAZE LEARNING; PREFRONTAL CORTEX; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEPTAL NUCLEI; STARTLE REACTION; TIME FACTORS;

EID: 79954607391     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.10.004     Document Type: Article

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