Does a reduction in anabolic signaling contribute to muscle wasting in chronic heart failure?

Journal of Applied Physiology

Volumn 110, Issue 4, 2011, Pages 869-870

  Timmerman, Kyle L ^a   Rasmussen, Blake B ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CACHEXIA; EDITORIAL; HEART FAILURE; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

CACHEXIA; HEART FAILURE; HUMANS; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION;

EID: 79954598447     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00072.2011     Document Type: Editorial

References (18)

1. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551, 1996. (Pubitemid 26413787)
2. Anker SD, Ponikowski P, Varney S, Chua TP, Clark AL, Webb- Peploe KM, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJ. Wasting as independent risk factor for mortality in chronic heart failure. Lancet 349: 1050-1053, 1997. (Pubitemid 27158249)
3. Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 10: 933-989, 2008.
4. Dreyer HC, Glynn EL, Lujan HL, Fry CS, DiCarlo SE, Rasmussen BB. Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway. J Appl Physiol 104: 27-33, 2008.
5. Drummond MJ, Dreyer HC, Pennings B, Fry CS, Dhanani S, Dillon EL, Sheffield-Moore M, Volpi E, Rasmussen BB. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol 104: 1452-1461, 2008.
6. Juenger J, Schellberg D, Kraemer S, Haunstetter A, Zugck C, Herzog W, Haass M. Health related quality of life in patients with congestive heart failure: Comparison with other chronic diseases and relation to functional variables. Heart 87: 235-241, 2002. (Pubitemid 34177677)
7. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82: 1065-1073, 2005. (Pubitemid 43779766)
8. McMurray JJ, Pfeffer MA. Heart failure. Lancet 365: 1877-1889, 2005. (Pubitemid 40744967)
9. Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE, Palmer BM, Maughan DW, Ades PA, Toth MJ. Mechanisms underlying skeletal muscle weakness in human heart failure: Alterations in single fiber myosin protein content and function. Circ Heart Fail 2: 700-706, 2009.
10. Rasmussen BB, Fujita S, Wolfe RR, Mittendorfer B, Roy M, Rowe VL, Volpi E. Insulin resistance of muscle protein metabolism in aging. FASEB J 20: 768-769, 2006. (Pubitemid 46671209)
11. Remme WJ, Swedberg K. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 22: 1527-1560, 2001. (Pubitemid 32801300)
12. Sandri M. Signaling in muscle atrophy and hypertrophy. Physiology 23: 160-170, 2008.
13. Sheffield-Moore M, Paddon-Jones D, Sanford AP, Rosenblatt JI, Matlock AG, Cree MG, Wolfe RR. Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise. Am J Physiol Endocrinol Metab 288: E922-E929, 2005. (Pubitemid 40547886)
14. Timmerman KL, Lee JL, Dreyer HC, Dhanani S, Glynn EL, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab 95: 3848-3857, 2010.
15. Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes 59: 2764- 2771, 2010.
16. Toth MJ, Matthews DE, Ades PA, Tischler MD, Van Buren P, Previs M, LeWinter MM. Skeletal muscle myofibrillar protein metabolism in heart failure: Relationship to immune activation and functional capacity. Am J Physiol Endocrinol Metab 288: E685-E692, 2005. (Pubitemid 40397202)
17. Toth MJ, Ward K, van der Velden J, Miller MS, VanBuren P, LeWinter MM, Ades PA. Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: Relationship to muscle size and function. J Appl Physiol (December 30, 2010). doi:10.1152/japplphysiol.00545.2010.
18. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucoseinduced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 85: 4481-4490, 2000. (Pubitemid 32157622)