Weight loss and hypophagia after high-dose AT 1-blockade is only observed after high dosing and depends on regular leptin signalling but not blood pressure

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 4, 2011, Pages 373-384

  Müller Fielitz, Helge ^a   Markert, Antonie ^a   Wittmershaus, Christian ^a   Pahlke, Friedrich ^a   Jöhren, Olaf ^a   Raasch, Walter ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

AT 1 receptor antagonist; Hypertension; Leptin resistance; Metabolic syndrome; Obesity; Weight loss

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CANDESARTAN; CILEXETIL; LEPTIN; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; FOOD INTAKE; HYPOPHAGIA; HYPOTHALAMUS; LEAN BODY WEIGHT; MALE; NONHUMAN; OBESITY; RAT; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; TREATMENT DURATION; WEIGHT REDUCTION; ZUCKER RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HYPOTHALAMUS; LEPTIN; MALE; OBESITY; RATS; RATS, INBRED SHR; RATS, ZUCKER; RECEPTORS, LEPTIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRAZOLES; WEIGHT LOSS;

EID: 79954593787     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-011-0602-5     Document Type: Article

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