Involvement of NF-κB in changes of IFN-γ-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages

Molecular Immunology

Volumn 48, Issue 9-10, 2011, Pages 1253-1262

  Hang, Do Thi Thu ^a   Song, Jae Young ^a   Kim, Min Young ^a   Park, Jin Woo ^a   Shin, Yeun Kyung ^a  

^a Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

Author keywords

CIITA MHC II; IFN ; Influenza virus; INOS; Macrophages; NF B

Indexed keywords

GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; JANUS KINASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE; STAT PROTEIN; STAT1 PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; INFLUENZA; INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON-GAMMA; JANUS KINASES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NUCLEAR PROTEINS; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

MURINAE; ORTHOMYXOVIRIDAE;

EID: 79954587366     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.03.010     Document Type: Article

References (44)

1. Akaike T., Noguchi Y., Ijiri S., Setoguchi K., Suga M., Zheng Y.M., Dietzschold B., Maeda H. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:2448-2453.
2. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 1997, 15:749-795.
3. Doherty P.C., Turner S.J., Webby R.G., Thomas P.G. Influenza and the challenge for immunology. Nat. Immunol. 2006, 7:449-455.
4. Faleiro L., Lazebnik Y. Caspases disrupt the nuclear-cytoplasmic barrier. J. Cell Biol. 2000, 151:951-959.
5. Graham M.B., Dalton D.K., Giltinan D., Braciale V.L., Stewart T.A., Braciale T.J. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J. Exp. Med. 1993, 178:1725-1732.
6. Hegde N.R., Chevalier M.S., Johnson D.C. Viral inhibition of MHC class II antigen presentation. Trends Immunol. 2003, 24:278-285.
7. Herold S., von Wulffen W., Steinmueller M., Pleschka S., Kuziel W.A., Mack M., Srivastava M., Seeger W., Maus U.A., Lohmeyer J. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J. Immunol. 2006, 177:1817-1824.
8. Hofmann P., Sprenger H., Kaufmann A., Bender A., Hasse C., Nain M., Gemsa D. Susceptibility of mononuclear phagocytes to influenza A virus infection and possible role in the antiviral response. J. Leukoc. Biol. 1997, 61:408-414.
9. Horimoto T., Kawaoka Y. Influenza: lessons from past pandemics, warnings from current incidents. Nat. Rev. Microbiol. 2005, 3:591-600.
10. Hui K.P., Lee S.M., Cheung C.Y., Ng I.H., Poon L.L., Guan Y., Ip N.Y., Lau A.S., Peiris J.S. Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J. Immunol. 2009, 182:1088-1098.
11. Israël A., Le Bail O., Hatat D., Piette J., Kieran M., Logeat F., Wallach D., Fellous M., Kourilsky P. TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors. EMBO J. 1989, 8:3793-3800.
12. Jayasekera J.P., Vinuesa C.G., Karupiah G., King N.J. Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. J. Gen. Virol. 2006, 87:3361-3371.
13. Johnson D.R., Pober J.S. HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Mol. Cell. Biol. 1994, 14:1322-1332.
14. Kacergius T., Ambrozaitis A., Deng Y., Gravenstein S. Neuraminidase inhibitors reduce nitric oxide production in influenza virus-infected and gamma interferon-activated RAW 264.7 macrophages. Pharmacol. Rep. 2006, 58:924-930.
15. Karupiah G., Chen J.H., Mahalingam S., Nathan C.F., MacMicking J.D. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J. Exp. Med. 1998, 188:1541-1546.
16. Kielar M.L., Sicher S.C., Penfield J.G., Jeyarajah D.R., Lu C.Y. Nitric oxide inhibits INFgamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes-class II MHC, Ii and H-2M. Class II TransActivator. Inflammation 2000, 24:431-445.
17. Kim H.M., Lee Y.W., Lee K.J., Kim H.S., Cho S.W., van Rooijen N., Guan Y., Seo S.H. Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J. Virol. 2008, 82:4265-4274.
18. Kumar N., Xin Z.T., Liang Y., Ly H. NF-kappaB signaling differentially regulates influenza virus RNA synthesis. J. Virol. 2008, 82:9880-9889.
19. Li W., Yang F., Liu Y., Gong R., Liu L., Feng Y., Hu P., Sun W., Hao Q., Kang L., Wu J., Zhu Y. Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur. J. Immunol. 2009, 39:1019-1024.
20. Ludwig S. Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy. J. Antimicrob. Chemother. 2009, 64:1-4.
21. MacMicking J., Xie Q.W., Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 1997, 15:323-350.
22. Moss R.B., Davey R.T., Steigbigel R.T., Fang F. Targeting pandemic influenza: a primer on influenza antivirals and drug resistance. J. Antimicrob. Chemother. 2010, 65:1086-1093.
23. Nguyen H.H., van Ginkel F.W., Vu H.L., Novak M.J., McGhee J.R., Mestecky J. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice. J. Virol. 2000, 74:5495-5501.
24. Nimmerjahn F., Dudziak D., Dirmeier U., Hobom G., Riedel A., Schlee M., Staudt L.M., Rosenwald A., Behrends U., Bornkamm G.W., Mautner J. Active NF-kappaB signalling is a prerequisite for influenza virus infection. J. Gen. Virol. 2004, 85:2347-2356.
25. Oeckinghaus A., Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb. Perspect. Biol. 2009, 1:a000034.
26. Pauli E.K., Schmolke M., Wolff T., Viemann D., Roth J., Bode J.G., Ludwig S. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog. 2008, 4:e1000196.
27. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29(9):e45.
28. Price G.E., Gaszewska-Mastarlarz A., Moskophidis D. The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice. J. Virol. 2000, 74:3996-4003.
29. Reed M. A simple method of estimating fifty percent endpoints. Am. J. Epidemiol. 1938, 27:493-497.
30. Reith W., LeibundGut-Landmann S., Waldburger J.M. Regulation of MHC class II gene expression by the class II transactivator. Nat. Rev. Immunol. 2005, 5:793-806.
31. Rodgers B., Mims C.A. Interaction of influenza virus with mouse macrophages. Infect. Immun. 1981, 31:751-757.
32. Schmolke M., Viemann D., Roth J., Ludwig S. Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome. J. Immunol. 2009, 183:5180-5189.
33. Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004, 75:163-189.
34. Suliman H.B., Ryan L.K., Bishop L., Folz R.J. Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001, 280:L69-78.
35. Sun K., Metzger D.W. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat. Med. 2008, 14:558-564.
36. Swain S.L., Dutton R.W., Woodland D.L. T cell responses to influenza virus infection: effector and memory cells. Viral Immunol. 2004, 17:197-209.
37. Tate M.D., Pickett D.L., van Rooijen N., Brooks A.G., Reading P.C. Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice. J. Virol. 2010, 84:7569-7580.
38. Tyner J.W., Uchida O., Kajiwara N., Kim E.Y., Patel A.C., O'Sullivan M.P., Walter M.J., Schwendener R.A., Cook D.N., Danoff T.M., Holtzman M.J. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat. Med. 2005, 11:1180-1187.
39. Uetani K., Hiroi M., Meguro T., Ogawa H., Kamisako T., Ohmori Y., Erzurum S.C. Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway. Eur. J. Immunol. 2008, 38:1559-1573.
40. Vila-del Sol V., Díaz-Muñoz M.D., Fresno M. Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. J. Leukoc. Biol. 2007, 81:272-283.
41. Wang G.F., Li W., Li K. Acute encephalopathy and encephalitis caused by influenza virus infection. Curr. Opin. Neurol. 2010, 23:305-311.
42. Wang X., Li M., Zheng H., Muster T., Palese P., Beg A.A., Garcia-Sastre A. Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J. Virol. 2000, 74:11566-11573.
43. Wei L., Sandbulte M.R., Thomas P.G., Webby R.J., Homayouni R., Pfeffer L.M. NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity. J. Biol. Chem. 2006, 281:11678-11684.
44. Wurzer W.J., Planz O., Ehrhardt C., Giner M., Silberzahn T., Pleschka S., Ludwig S. Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J. 2003, 22:2717-2728.