Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry

Tetrahedron Letters

Volumn 52, Issue 20, 2011, Pages 2583-2585

  Mollica, Adriano ^a   Stefanucci, Azzurra ^a   Feliciani, Federica ^a   Lucente, Gino ^b   Pinnen, Francesco ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Brominated amino acids; Indole; Isatin; Racemic resolution; Tryptophan

Indexed keywords

5,6 DIBROMOTRYPTOPHAN DERIVATIVE; AMIDE; PEPTIDE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SYNTHESIS; ARTICLE; BROMINATION; DEACETYLATION; RACEMIC MIXTURE; REDUCTION;

EID: 79954580560     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.03.041     Document Type: Article

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36. Chromatographic conditions. Column: Chiralpak IA 250 mm L × 4.6 mm I.D. Conditions: detection UV at 220 nm; flow rate: 0.9 ml/min; injection of 20 μL of a solution containing 1 mg/mL of analyte; isocratic elution with a mixture of hexane/2-propanol/TFA (85:15:0.1) in 30 min, for chiral HPLC runs of product 3, 4 and 6 (further details in Supplementary data).