Mechanisms of whole chromosome gains in tumors - Many answers to a simple question

Cytogenetic and Genome Research

Volumn 133, Issue 2-4, 2011, Pages 190-201

  Gisselsson, D ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aneuploidy; Cancer; Computer simulation; Multipolar mitosis; Non disjunction; Trisomy

Indexed keywords

ARTICLE; CANCER GENETICS; CELL POPULATION; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CHROMOSOME SEGREGATION; CLONE; COMPUTER MODEL; COPY NUMBER VARIATION; CYTOGENETICS; CYTOKINESIS; HUMAN; KARYOTYPE; MITOSIS; NONDISJUNCTION; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE FITNESS; SISTER CHROMATID; SOMATIC CELL; TETRAPLOIDY; WHOLE CHROMOSOME GAIN;

ANIMALS; CHROMOSOME ABERRATIONS; CYTOKINESIS; GENE DOSAGE; HUMANS; MITOSIS; NEOPLASMS;

EID: 79954578030     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322480     Document Type: Article

References (44)

1. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, et al: Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406: 641-645 (2000). (Pubitemid 30641052)
2. Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, et al: Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci USA 105: 3443-3448 (2008). (Pubitemid 351723572)
3. Bonnici AV, Birjandi F, Spencer JD, Fox SP, Berry AC: Chromosomal abnormalities in Dupuytren's contracture and carpal tunnel syndrome. J Hand Surg Br 17: 349-355 (1992).
4. Boveri T: Zur Frage der Entstehung maligner Tumoren (Verlag von Gustav Fischer, Jena 1914).
5. Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, et al: Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer 33: 310-321 (2002). (Pubitemid 34130938)
6. Brisset S, Schleiermacher G, Peter M, Mairal A, Oberlin O, et al: CGH analysis of secondary genetic changes in Ewing tumors: correlation with metastatic disease in a series of 43 cases. Cancer Genet Cytogenet 130: 57-61 (2001). (Pubitemid 32979167)
7. Broberg K, Hoglund M, Lindstrand A, Toksvig- Larsen S, Mandahl N, Mertens F: Polyclonal expansion of cells with trisomy 7 in synovia from patients with osteoarthritis. Cytogenet Cell Genet 83: 30-34 (1998). (Pubitemid 29062677)
8. Bukvic N, Gentile M, Susca F, Fanelli M, Serio G, et al: Sex chromosome loss, micronuclei, sister chromatid exchange and aging: a study including 16 centenarians. Mutat Res 498: 159-167 (2001). (Pubitemid 32973671)
9. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, et al: Mutations of mitotic checkpoint genes in human cancers. Nature 392: 300-303 (1998). (Pubitemid 28155105)
10. Dal Cin P, De Smet L, Sciot R, Van Damme B, Van den Berghe H: Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease. Cancer Genet Cytogenet 108: 137-140 (1999). (Pubitemid 29021957)
11. Duesberg P, Li R, Fabarius A, Hehlmann R: The chromosomal basis of cancer. Cell Oncol 27: 293-318 (2005). (Pubitemid 43000357)
12. Ganem NJ, Godinho SA, Pellman D: A mechanism linking extra centrosomes to chromosomal instability. Nature 460: 278-282 (2009).
13. Gertow K, Cedervall J, Unger C, Szoke K, Blennow E, et al: Trisomy 12 in HESC leads to no selective in vivo growth advantage in teratomas, but induces an increased abundance of renal development. J Cell Biochem 100: 1518-1525 (2007). (Pubitemid 46515583)
14. Ghadimi BM, Sackett DL, Difilippantonio MJ, Schröck E, Neumann T, et al: Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 27: 183-190 (2000). (Pubitemid 30030317)
15. Giaretti W: Vanishing conflicts on cancer theories. Cell Oncol 28: 1-2 (2006). (Pubitemid 43673123)
16. Gisselsson D: Classification of chromosome segregation errors in cancer. Chromosoma 117: 511-519 (2008).
17. Gisselsson D, Hakanson U, Stoller P, Marti D, Jin Y, et al: When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses. PLoS ONE 3:e1871 (2008).
18. Gisselsson D, Jin Y, Lindgren D, Persson J, Gisselsson L, et al: Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis. Proc Natl Acad Sci USA 107:20489-20493 (2010).
19. Hanks S, Coleman K, Reid S, Plaja A, Firth H, et al: Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B . Nat Genet 36: 1159-1161 (2004). (Pubitemid 41288963)
20. Hassold T, Hunt P: To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2: 280-291 (2001). (Pubitemid 33674776)
21. Johansson B, Heim S, Mandahl N, Mertens F, Mitelman F: Trisomy 7 in nonneoplastic cells. Genes Chromosomes Cancer 6: 199-205 (1993). (Pubitemid 23111753)
22. King RW: When 2 + 2 = 5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta 1786: 4-14 (2008).
23. Kops GJ: The kinetochore and spindle checkpoint in mammals. Front Biosci 13: 3606-3620 (2008). (Pubitemid 351594646)
24. Kullendorff CM, Soller M, Wiebe T, Mertens F: Cytogenetic findings and clinical course in a consecutive series of Wilms tumors. Cancer Genet Cytogenet 140: 82-87 (2003). (Pubitemid 36110647)
25. Lengauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancers. Nature 386: 623-627 (1997). (Pubitemid 27175430)
26. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 396: 643-649 (1998). (Pubitemid 29003936)
27. Meijer GA: Chromosomes and cancer, Boveri revisited. Cell Oncol 27: 273-275 (2005). (Pubitemid 41831634)
28. Mertens F, Palsson E, Lindstrand A, Toksvig- Larsen S, Knuutila S, et al: Evidence of somatic mutations in osteoarthritis. Hum Genet 98: 651-656 (1996). (Pubitemid 26387950)
29. Mitelman F: The cytogenetic scenario of chronic myeloid leukemia. Leuk Lymphoma 11 Suppl 1: 11-15 (1993). (Pubitemid 23274129)
30. Mitelman F, Johansson B, Mertens F: Mitelman Database of Chromosome Aberration in Cancer. http://cgap.nci.nih.gov/Chromosomes/ Mitelman (2010).
31. Myrie KA, Percy MJ, Azim JN, Neeley CK, Petty EM: Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett 152: 193-199 (2000). (Pubitemid 30201502)
32. Parmigiani G, Boca S, Lin J, Kinzler KW, Velculescu V, Vogelstein B: Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 93: 17-21 (2009).
33. Paulsson K, Johansson B: Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris) 55: 37-48 (2007). (Pubitemid 46217945)
34. Paulsson K, Johansson B: High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 48: 637-660 (2009).
35. Paulsson K, Morse H, Fioretos T, Behrendtz M, Strombeck B, Johansson B: Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 44: 113-122 (2005). (Pubitemid 41306640)
36. Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, et al: Inactivation of hCDC4 can cause chromosomal instability. Nature 428: 77-81 (2004). (Pubitemid 38332360)
37. Ruff P, Saragas E, Poulos M, Weaving A: Patterns of clonal evolution in transformed chronic myelogenous leukemia. Cancer Genet Cytogenet 81: 182-184 (1995).
38. Sato M, Sekido Y, Horio Y, Takahashi M, Saito H, et al: Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. Jpn J Cancer Res 91: 504-509 (2000). (Pubitemid 30392321)
39. Saunders WS, Shuster M, Huang X, Gharaibeh B, Enyenihi AH, et al: Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc Natl Acad Sci USA 97: 303-308 (2000). (Pubitemid 30055826)
40. Schultz N, Onfelt A: Video time-lapse study of mitosis in binucleate V79 cells: chromosome segregation and cleavage. Mutagenesis 9: 117-123 (1994). (Pubitemid 24090153)
41. Shi Q, King RW: Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437: 1038-1042 (2005). (Pubitemid 41486986)
42. Stewénius Y, Gorunova L, Jonson T, Larsson N, Höglund M, et al: Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc Natl Acad Sci USA 102: 5541-5546 (2005). (Pubitemid 40530294)
43. Wang SA, Jabbar K, Lu G, Chen SS, Galili N, et al: Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features. Leukemia 24: 740-747 (2010).
44. Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, et al: Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322: 703-709 (2008).