Chemical Synthesis and Biological Evaluation of the Englerin Analogues

ChemMedChem

Volumn 6, Issue 3, 2011, Pages 420-423

  Chan, Kok Ping ^a   Chen, David Y K ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

Author keywords

Antitumor agents; Cytotoxicity; Natural products; Total synthesis

Indexed keywords

ALKYLATING AGENT; ENGLERIN A; ENGLERIN B; ENGLERIN C; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; KIDNEY CARCINOMA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; PHYLLANTHUS; SESQUITERPENES, GUAIANE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952094960     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000544     Document Type: Article

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16. It is worth noting that the englerin analogues described here were synthesized in racemic forms. Therefore, more potent biological activities may be expected with optically pure material. Furthermore, both the cyclopropane analogue 8d and lactate analogue 24 were prepared as mixture of diastereoisomers. Therefore, diastereomerically pure compounds may also exhibit improved biological activities.