Influence of low dose irradiation on differentiation, maturation and T-cell activation of human dendritic cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 709-710, Issue , 2011, Pages 32-39

  Jahns, Jutta ^b   Anderegg, Ulf ^b   Saalbach, Anja ^b   Rosin, Britt ^b   Patties, Ina ^b   Glasow, Annegret ^b   Kamprad, Manja ^b   Scholz, Markus ^b   Hildebrandt, Guido ^a,b  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Dendritic cells; Differentiation; Inflammation; Low dose irradiation; Non targeted effects; T cells

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; PRIORITY JOURNAL; RADIATION DOSE; T LYMPHOCYTE ACTIVATION;

CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DENDRITIC CELLS; HUMANS; LYMPHOCYTE ACTIVATION; RADIATION DOSAGE; T-LYMPHOCYTES; X-RAYS;

EID: 79954572259     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.02.007     Document Type: Article

References (42)

1. Little M.P. Do non-targeted effects increase or decrease low dose risk in relation to the linear non-threshold (LNT) model?. Mutat. Res. 2010, 687:17-27.
2. Little M.P., Tawn E.J., Tzoulaki I., Wakeford R., Hildebrandt G., Paris F., Tapio S., Elliott P. Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms. Radiat. Environ. Biophys. 2010, 49:139-153.
3. Hildebrandt G. Non cancer diseases and non-targeted effects. Mutat. Res. 2010, 687:73-77.
4. Little M.P., Tawn E.J., Tzoulaki I., Wakeford R., Hildebrandt G., Paris F., Tapio S., Elliott P. A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms. Radiat. Res. 2008, 169:99-109.
5. Schultz-Hector S., Trott K.-R. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data. Int. J. Radiat. Oncol. Biol. Phys. 2007, 67:10-18.
6. Milacic S. Chromosomal aberrations after exposure to low doses of ionizing radiation. J. BUON. 2009, 14:641-646.
7. Serhatlioĝlu S., Oĝur E., Ozan A.T., Gürsu F., Gödekmerdan A., Ayar A. Biochemical and immunological effects of ionizing radiation in radiology staff members. Tani. Girisim. Radyol. 2004, 10:97-102.
8. Ghiassi-Nejad M., Zakeri F., Assaei R.G., Kariminia A. Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran. J. Environ. Radioact. 2004, 74:107-116.
9. Gridley D.S., Rizvi A., Luo-Owen X., Makinde A.Y., Pecaut M.J. Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression. Int. J. Radiat. Biol. 2009, 85:250-261.
10. Ina Y., Sakai K. Activation of immunological network by chronic low-dose-rate irradiation in wild-type mouse strains: analysis of immune cell populations and surface molecules. Int. J. Radiat. Biol. 2005, 81:721-729.
11. Ina Y., Tanooka H., Yamada T., Sakai K. Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat. Res. 2005, 163:153-158.
12. Sakai K., Nomura T., Ina Y. Enhancement of bio-protective functions by low dose/dose-rate radiation. Dose Response 2006, 4:327-332.
13. Tsuruga M., Taki K., Ishii G., Sasaki Y., Furukawa C., Sugihara T., Nomura T., Ochiai A., Magae J. Amelioration of type II diabetes in db/db mice by continuous low-dose-rate gamma irradiation. Radiat. Res. 2007, 167:592-599.
14. Liu S.Z. Radiation-induced change in lymphocyte proliferation and its neuroendocrine regulation: dose-response relationship and pathophysiological implications. Nonlinearity Biol. Toxicol. Med. 2004, 2:233-243.
15. Hildebrandt G., Seed M.P., Freemantle C.N., Alam C.A., Colville-Nash P.R., Trott K.R. Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. Int. J. Radiat. Biol. 1998, 74:367-378.
16. Hildebrandt G., Jahns J., Hindemith M., Spranger S., Sack U., Kinne R.W., Madaj-Sterba P., Wolf U., Kamprad F. Effects of low dose radiation therapy on adjuvant induced arthritis in rats. Int. J. Radiat. Biol. 2000, 76:1143-1153.
17. Hildebrandt G., Radlingmayr A., Rosenthal S., Rothe R., Jahns J., Hindemith M., Rödel F., Kamprad F. Low-dose radiotherapy (LD-RT) and the modulation of iNOS expression in adjuvant-induced arthritis in rats. Int. J. Radiat. Biol. 2003, 79:993-1001.
18. Hildebrandt G., Loppnow G., Jahns J., Hindemith M., Anderegg U., Saalbach A., Kamprad F. Inhibition of the iNOS pathway in inflammatory macrophages by low-dose X-irradiation in vitro. Is there a time dependence?. Strahlenther. Onkol. 2003, 179:158-166.
19. Liebmann A., Hindemith M., Jahns J., Madaj-Sterba P., Weisheit S., Kamprad F., Hildebrandt G. Low-dose X-irradiation of adjuvant-induced arthritis in rats. Efficacy of different fractionation schedules. Strahlenther. Onkol. 2004, 180:165-172.
20. Schaue D., Jahns J., Hildebrandt G., Trott K.R. Radiation treatment of acute inflammation in mice. Int. J. Radiat. Biol. 2005, 81:657-667.
21. Rödel F., Kamprad F., Sauer R., Hildebrandt G. Functional and molecular aspects of anti-inflammatory effects of low-dose radiotherapy. Strahlenther. Onkol. 2002, 178:1-9.
22. Rödel F., Keilholz L., Herrmann M., Sauer R., Hildebrandt G. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int. J. Radiat. Biol. 2007, 83:357-366.
23. Gong S.L., Liu S.C., Liu J.X., Zhang Y.C., Liu S.Z. Adaptive response of thymocyte apoptosis and cell cycle progression induced by low dose X-ray irradiation in mice. Biomed. Environ. Sci. 2000, 13:180-188.
24. Liu S.Z., Jin S.Z., Liu X.D. Radiation-induced bystander effect in immune response. Biomed. Environ. Sci. 2004, 17:40-46.
25. Demaria S., Ng B., Devitt M.L., Babb J.S., Kawashima N., Liebes L., Formenti S.C. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int. J. Radiat. Oncol. Biol. Phys. 2004, 58:862-870.
26. Kaminski J.M., Shinohara E., Summers J.B., Niermann K.J., Morimoto A., Brousal J. The controversial abscopal effect. Cancer Treat. Rev. 2005, 31:159-172.
27. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., Palucka K. Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000, 18:767-811.
28. Loser K., Beissert S. Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D. Int. Immunopharmacol. 2009, 9:587-589.
29. Denfeld R.W., Hara H., Tesmann J.P., Martin S., Simon J.C. UVB-irradiated dendritic cells are impaired in their APC function and tolerize primed Th1 cells but not naive CD4+ T cells. J. Leukoc. Biol. 2001, 69:548-554.
30. Reuben J.M., Korbling M., Gao H., Lee B.N. The effect of low dose gamma irradiation on the differentiation and maturation of monocyte derived dendritic cells. J. Gravit. Physiol. 2004, 11:49-52.
31. Conti L., Cardone M., Varano B., Puddu P., Belardelli F., Gessani S. Role of cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes. Eur. J. Immunol. 2008, 38:1-13.
32. Pulendran B., Maraskovsky E., Banchereau J., Maliszewski C. Modulating the immune response with dendritic cells and their growth factors. Trends Immunol. 2001, 22:41-47.
33. Chang W.L., Baumgarth N., Eberhardt M.K., Lee C.Y., Baron C.A., Gregg J.P., Barry P.A. Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity. J. Immunol. 2007, 178:7794-7804.
34. Buelens C., Verhasselt V., DeGroote D., Thielemanns K., Goldmann M., Willems F. Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur. J. Immunol. 1977, 27:756-762.
35. More A.S., Quaratino S., Douek D.C., Londei M. Split activity of interleukin-10 on antigen capture and antigen presentation by human dendritic cells: definition of a maturation step. Eur. J. Immunol. 1997, 27:26-34.
36. Saalbach A., Klein C., Sleemann J., Sack U., Kauer F., Gebhardt C., Averbeck M., Anderegg U., Simon J.C. Dermal fibroblasts induce maturation of dendritic cells. J. Immunol. 2007, 178:4966-4974.
37. Cao M.D., Chen Z.D., Xing Y. Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reaction. Cell Biol. Int. 2004, 28:223-228.
38. Lebre M.C., Burwell T., Vieira P.L., Lora J., Coyle A.J., Kapsenberg M.L., Clausen B.E., De Jong E.C. Differential expression of inflammatory chemokines by Th1-and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation. Immunol. Cell Biol. 2005, 83:525-535.
39. Nishioka Y., Wen H., Mitani K., Robbins P.D., Lotze M.T., Sone S., Tahara H. Differential effects of IL12 on the generation of alloreactive CTL mediated by murine and human denditic cells: a critical role for nitric oxide. J. Leukoc. Biol. 2003, 73(5):621-629.
40. Jahns J., Anderegg U., Glasow A., Hildebrandt G. Die Wirkung niedriger Strahlendosen auf die Expression von TNF-α und IL10 mRNA in humanen PBMC und monozytären Zelllinien (U937, THP1). Strahlenther. Onkol. 2007, 183(Suppl. 1):54.
41. Smith K.A. Interleukin-2: inception, impact, and implications. Science 1988, 240:1169-1176.
42. Bonnefoy-Berard N., Verrier B., Vincent C., Revillard J.P. Inhibition of CD25 (IL-2Rα) expression and T-cell proliferation by polyclonal anti-thymocyte globulins. Immunology 1992, 77(1):61-67.