Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species

Chinese Journal of Cancer

Volumn 30, Issue 1, 2011, Pages 41-53

  Hu, Zhe Yu ^a,d   Wang, Jing ^a   Cheng, Gang ^b   Zhu, Xiao Feng ^a   Huang, Peng ^b   Yang, Dajun ^c   Zeng, Yi Xin ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Ascenta Therapeutics   (United States)

^d First Hospital of Changsha City   (China)

Author keywords

Apogossypolone; Mitochondria; Photodynamic therapy; Reactive oxygen species; Singlet oxygen

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; APOGOSSYPOLONE; GOSSYPOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; SINGLET OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; ILLUMINATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOSIS INHIBITION; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PHOTOACTIVATION; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; TUMOR DIFFERENTIATION; TUMOR XENOGRAFT;

EID: 79954565017     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.010.10295     Document Type: Article

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