Effect of clonidine on cardiac baroreflex delay in humans and rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 4, 2011, Pages

  Cividjian, Andrei ^a   Toader, Emil ^a   Wesseling, Karel H ^c   Karemaker, John M ^c   McAllen, Robin ^b   Quintin, Luc ^a  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

2 agonist; Cardiac vagal motoneurons; Lag; Latency; Sequences

Indexed keywords

CLONIDINE;

ADULT; ARTICLE; ELECTROSTIMULATION; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MOLECULAR MECHANICS; MOTONEURON; NONHUMAN; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; VAGUS NERVE STIMULATION;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADULT; ANIMALS; BAROREFLEX; BLOOD PRESSURE; CLONIDINE; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; HEART; HEART RATE; HUMANS; MALE; MIDDLE AGED; MODELS, ANIMAL; MOTOR NEURONS; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME; TIME FACTORS;

EID: 79954553002     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00438.2010     Document Type: Article

References (56)

1. Aars H. Effects of clonidine on aortic diameter and aortic baroreceptor activity. Eur J Pharmacol 20: 52-59, 1972.
2. Alvarez-Ramirez J, Rodriguez E, Echevarria JC. Delays in the human heartbeat dynamics (Abstract). Chaos 19: 028502, 2009.
3. Bertinieri G, Di Rienzo M, Cavallazzi A, Ferrari AU, Pedotti A, Mancia G. Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats. Am J Physiol Heart Circ Physiol 254: H377-H383, 1988.
4. Borst C, Karemaker J. Time delays in the human baroreceptor reflex. J Auton Nerv Syst 9: 399-409, 1983.
5. Brown GL, Eccles JC. The action of a single vagal volley on the rhythm of the heart beat. J Physiol 82: 211-241, 1934.
6. Casadei B, Meyer T, Coats AJS, Conway J, Sleight P. Baroreflex control of stroke volume in man: an effect mediated by the vagus. J Physiol 448: 539-550, 1992.
7. Cividjian A, Rentero N, McAllen RM, Quintin L. A simple method for generating a blood pressure-unit activity relationship for central cardiovascular neurons in the rat. Exp Physiol 87: 535-538, 2002.
8. Coleman TG. Arterial baroreflex control of heart rate in the conscious rat. Am J Physiol Heart Circ Physiol 238: H515-H520, 1980.
9. DeBoer RW, Karemaker J, Strackee J. Relationships between shortterm blood pressure fluctuations and heart rate variability in resting subjects. II. A simple model. Med Biol Eng Comput 23: 359-364, 1985.
10. DeBoer RW, Karemaker JM, Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
11. Demir SS, Clark JW, Giles WR. Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model. Am J Physiol Heart Circ Physiol 276: H2221-H2244, 1999.
12. Di Rienzo M, Bertinieri G, Mancia G, Pedotti A. A new method for evaluating the baroreflex role by a joint pattern analysis of pulse interval and systolic blood pressure series. Med Biol Eng Comput 23: 313-314, 1985.
13. Eckberg DL, Eckberg MJ. Human sinus node responses to repetitive, ramped carotid baroreceptor stimuli. Am J Physiol Heart Circ Physiol 242: H638-H644, 1982.
14. Faris I, Iannos J, Jamieson G, Ludbrook J. Comparison of methods for eliciting the baroreceptor-heart rate reflex in conscious rabbits. Clin Exp Pharmacol Physiol 7: 281-291, 1980.
15. Fritsch JM, Eckberg DL, Graves LD, Wallin BG. Arterial pressure ramps provoke linear increases of heart period in humans. Am J Physiol Regul Integr Comp Physiol 251: R1086-R1090, 1986.
16. Gulli G, Claydon VE, Cooper VL, Hainsworth R. R-R interval-blood pressure interaction in subjects with different tolerances to orthostatic stress. Exp Physiol 90: 367-375, 2005.
17. Guyenet P. Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites? Am J Physiol Regul Integr Comp Physiol 273: R1580-R1584, 1997.
18. Guyenet P, Darnall RA, Riley TA. Rostral ventrolateral medulla and symathorespiratory integration in rats. Am J Physiol Regul Integr Comp Physiol 259: R1063-R1074, 1990.
19. Head GA, McCarty R. Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats. J Auton Nerv Syst 21: 203-213, 1987.
20. Hill-Smith I, Purves RD. Synaptic delay in the heart: an ionophoretic study. J Physiol 279: 31-54, 1978.
21. Imholz BP, Wieling W, van Montfrans A, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 38: 605-616, 1998.
22. Jalife J, Moe G. Phasic effects of vagal stimulation on pacemaker activity of the isolated sinus node of the young cat. Circ Res 45: 595-607, 1979.
23. Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation 115: 872-880, 2007.
24. Kobinger W, Walland A. Evidence for a central activation of a vagal cardiodepressor reflex by clonidine. Eur J Pharmacol 19: 203-209, 1972.
25. Kobinger W, Walland A. Modulating effect of central adrenergic neurons on a vagally mediated cardioinhibitory reflex. Eur J Pharmacol 22: 344-350, 1973.
26. Kooner JS, Peart WS, Mathias CJ. The haemodynamic and hormonal responses after clonidine occur independently of sedation in essential hypertension. Br J Clin Pharmacol 28: 249-255, 1989.
27. Korner PI, Oliver JR, Sleight P, Chalmers JP, Robinson JS. Effect of clonidine on the baroreceptor-heart rate reflex and on single aortic baroreceptor fibre discharge. Eur J Pharmacol 28: 189-198, 1974.
28. Kuras A, Gutmaniene N. Preparation of carbon-fibre microelectrode for extracellular recording of synaptic potentials. J Neurosci Methods 62: 207-212, 1995.
29. Laubie M, Schmitt H, Drouillat M. Action of clonidine on the baroreceptor pathway and medullary sites mediating vagal bradycardia. Eur J Pharmacol 38: 293-303, 1976.
30. Lipski J. Antidromic activation of neurones as an analytical tool in the study of the central nervous system. J Neurosci Methods 4: 1-32, 1981.
31. McAllen RM, Spyer KM. The baroreceptor input to cardiac vagal motoneurones. J Physiol 282: 365-374, 1978.
32. Mermet C, Quintin L. Effect of clonidine on the catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study. Eur J Pharmacol 204: 105-107, 1991.
33. National Institutes of Health. Institutional policies. In: Guide for the Care and Use of Laboratory Animals. Washington, DC: National Institutes of Health, 1985, p. 3-10.
34. Ng GA, Brack KE, Coote JH. Effects of direct sympathetic and vagus nerve stimulation on the physiology of the whole heart-a novel model of isolated Langendorff perfused rabbit heart with intact dual autonomic innervation. Exp Physiol 86: 319-329, 2001.
35. Oosting J, Struijker-Boudier HAJ, Janssen JA. Validation of a continuous baroreceptor reflex sensitivity index calculated from spontaneous fluctuations of blood pressure and pulse interval in rats. J Hypertens 15: 391-399, 1997.
36. Parlow J, Begou G, Sagnard P, Cottet-Emard JM, Levron JC, Annat G, Bonnet F, Ghignone M, Hughson RL, Viale JP, Quintin L. Cardiac baroreflex during the postoperative period in patients with hypertension: effect of clonidine. Anesthesiology 90: 681-692, 1999.
37. Parlow J, Viale JP, Annat G, Hughson RL, Quintin L. Spontaneous cardiac baroreflex in humans: comparison with drug-induced responses. Hypertension 25: 1058-1068, 1995.
38. Pickering TG, Davies J. Estimation of the conduction time of the baroreceptor-cardiac reflex in man. Cardiovasc Res 7: 213-219, 1973.
39. Quintin L, Gillon JY, Saunier CF, Chouvet G, Ghignone M. Continuous volume infusion improves circulatory stability in anesthetized rats. J Neurosci Methods 30: 77-83, 1989.
40. Rentero N, Cividjian A, Trevaks D, Pequignot JM, Quintin L, Mc-Allen RM. Activity patterns of cardiac vagal motoneurons in rat nucleus ambiguus. Am J Physiol Regul Integr Comp Physiol 283: R1327-R1334, 2002.
41. Robson RD, Kaplan HR. An involvement of ST155 [2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, Catapress R] in cholinergic mechanisms. Eur J Pharmacol 5: 328-337, 1969.
42. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 372: 135-165, 1996.
43. Salgado HC, Krieger EM. Time course of baroreceptor resetting in short-term hypotension in the rat. Am J Physiol Heart Circ Physiol 234: H552-H556, 1978.
44. Schoener EP, Pitts DK. Cardiovascular effects of centrally perfused clonidine. Eur J Pharmacol 114: 297-303, 1985.
45. Seidel H, Herzel H, Eckberg DL. Phase dependencies of the human baroreceptor reflex. Am J Physiol Heart Circ Physiol 272: H2040-H2053, 1997.
46. Sleight P, West MJ, Korner PI, Oliver JR, Chalmers JP, Robinson JL. The action of clonidine on the baroreflex control of heart rate in conscious animals and man and on single aortic baroreceptor discharge in the rabbit. Arch Int Pharmacodyn Ther 214: 4-11, 1975.
47. Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man. Circ Res 24: 109-121, 1969.
48. Sun MK, Guyenet P. Effect of clonidine and γ-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat. Brain Res 368: 1-17, 1986.
49. 2-adrenergic receptors in nucleus tractus solitarius is required for the baroreceptor reflex. Brain Res 576: 297-303, 1992.
50. 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 372: 111-134, 1996.
51. 2-Adrenergic transmission and human baroreflex regulation. Hypertension 43: 1035-1041, 2004.
52. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 43: 1042-1047, 2004.
53. Toader E, Cividjian A, Rentero N, McAllen RM, Quintin L. Cardioinhibitory actions of clonidine assessed by cardiac vagal motoneuron recordings. J Hypertens 26: 1169-1180, 2008.
54. 2-agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related agents. Brain Res Rev 7: 69-101, 1984.
55. Warner HR, Cox A. A mathematical model of heart rate control by sympathetic and vagus efferent information. J Appl Physiol 17: 349-355, 1962.
56. Westerhof BE, Gisolf J, Stok WJ, Wesseling KH, Karemaker J. Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set. J Hypertens 22: 1371-1380, 2004.