The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy

Oncology Reports

Volumn 25, Issue 6, 2011, Pages 1565-1571

  Zhou, Hui ^a   Rao, Jing ^b   Lin, Jian ^a   Yin, Bo ^a   Sheng, Hansong ^a   Lin, Fengchun ^a   Zhang, Nu ^a   Yang, Lin ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Medulloblastoman the insulin like growth factor I receptor; NVP ADW742; Temozolomide

Indexed keywords

4 AMINO 5 (3 BENZYLOXYPHENYL) 7 [3 (1 PYRROLIDINYLMETHYL)CYCLOBUTYL] 7H PYRROLO[2,3 D]PYRIMIDINE; CHOLECYSTOKININ OCTAPEPTIDE; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; TEMOZOLOMIDE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEDULLOBLASTOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; DACARBAZINE; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MEDULLOBLASTOMA; POLYMERASE CHAIN REACTION; PYRIMIDINES; PYRROLES; RECEPTOR, IGF TYPE 1;

EID: 79954545017     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1233     Document Type: Article

References (24)

1. Crawford JR, MacDonald TJ and Packer RJ: Medulloblastoma in childhood: new biological advances. Lancet Neurol 6: 1073-1085, 2007. (Pubitemid 350116703)
2. Rossi A, Caracciolo V, Russo G, Reiss K and Giordano A: Medulloblastoma: from molecular pathology to therapy. Clin Cancer Res 14: 971-976, 2008. (Pubitemid 351302541)
3. Patti R, Reddy CD, Geoerger B, Grotzer MA, Raghunath M, Sutton LN and Phillips PC: Autocrine secreted insulin-like growth factor-I stimulates MAP kinase-dependent mitogenic effects in human primitive neuroectodermal tumor/medulloblastoma. Int J Oncol 16: 577-584, 2000.
4. Wang JY, Del Valle L, Gordon J, Rubini M, Romano G, Croul S, Peruzzi F, Khalili K and Reiss K: Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas. Oncogene 20: 3857-3868, 2001. (Pubitemid 32646196)
5. Del Valle L, Enam S, Lassak A, Wang JY, Croul S, Khalili K and Reiss K: Insulin-like growth factor I receptor activity in human medulloblastomas. Clin Cancer Res 8: 1822-1830, 2002.
6. Sell C, Baserga R and Rubin R: Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res 55: 303-306, 1995.
7. Morrione A, Romano G, Navarro M, Reiss K, Valentinis B, Dews M, Eves E, Rosner MR and Baserga R: Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells. Cancer Res 60: 2263-2272, 2000. (Pubitemid 30225193)
8. Baserga R: The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res 55: 249-252, 1995.
9. Hewish M, Chau I and Cunningham D: Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drug Discov 4: 54-72, 2009.
10. Reiss K: Insulin-like growth factor-I receptor - a potential therapeutic target in medulloblastomas. Expert Opin Ther Targets 6: 539-544, 2002.
11. Ullrich A and Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212, 1990.
12. Navarro M and Baserga R: Limited redundancy of survival signals from the type 1 insulin-like growth factor receptor. Endocrinology 142: 1073-1081, 2001. (Pubitemid 32202816)
13. Garcia-Echeverria C: Medicinal chemistry approaches to target the kinase activity of IGF-1R. IDrugs 9: 415-419, 2006.
14. Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG and Anderson KC: Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene 21: 5673-5683, 2002. (Pubitemid 35333000)
15. Morgan GJ, Krishnan B, Jenner M and Davies FE: Advances in oral therapy for multiple myeloma. Lancet Oncol 7: 316-325, 2006.
16. Kulik G, Klippel A and Weber MJ: Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase and Akt. Mol Cell Biol 17: 1595-1606, 1997. (Pubitemid 27097389)
17. Urbanska K, Trojanek J, Del Valle L, Eldeen MB, Hofmann F, Garcia-Echeverria C, Khalili K and Reiss K: Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines. Oncogene 26: 2308-2317, 2007. (Pubitemid 46572811)
18. Parrizas M and LeRoith D: Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bd-xL gene product. Endocrinology 138: 1355-1358, 1997. (Pubitemid 27089798)
19. Minshall C, Arkins S, Straza J, Conners J, Dantzer R, Freund GG and Kelley KW: IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of EL-3-deprived myeloid progenitors. J Immunol 159: 1225-1232, 1997. (Pubitemid 127484099)
20. +/- mouse cerebellum. Mol Cancer 9: 53, 2010.
21. Martins AS, Mackintosh C, Martín DH, Campos M, Hernández T, Ordóñez JL and De Alava E: Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 12: 3532-3540, 2006.
22. Warshamana-Greene GS, Litz J, Buchdunger E, Garcia-Echeverria C, Hofmann F and Krystal GW: The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 11: 1563-1571, 2005. (Pubitemid 40315241)
23. Warshamana-Greene GS, Litz J, Buchdunger E, Hofmann F, Garcia-Echeverria C and Krystal GW: The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol Cancer Ther 3: 527-535, 2004. (Pubitemid 39193731)
24. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, Garcia-Echeverria C, Pearson MA, Hofmann F, Anderson KC and Kung AL: Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5: 221-230, 2004. (Pubitemid 38402114)