Urothelium-dependent and urothelium-independent detrusor contractility mediated by nitric oxide synthase and cyclooxygenase inhibition

Neurourology and Urodynamics

Volumn 30, Issue 4, 2011, Pages 619-625

  Santoso, Aneira Gracia Hidayat ^a   Lo, Wan Ning ^a   Liang, Willmann ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

contractility; cyclooxygenase; detrusor smooth muscle; longitudinal; nitric oxide synthase; transverse; urothelium

Indexed keywords

NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DETRUSOR MUSCLE; ENZYME INHIBITION; ENZYME POLYMORPHISM; ENZYME REGULATION; EVOKED MUSCLE RESPONSE; FEMALE; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE TONE; STIMULUS RESPONSE; UROTHELIUM;

ANALYSIS OF VARIANCE; ANIMALS; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; FEMALE; INDOMETHACIN; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; URINARY BLADDER; UROTHELIUM;

EID: 79954535372     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21015     Document Type: Article

References (25)

1. Andersson K-E, Wein AJ,. Pharmacology of the lower urinary tract: Basis for current and future treatments of urinary incontinence. Pharmacol Rev 2004; 56: 581-631. (Pubitemid 40003785)
2. Birder LA, Kanai AJ, Cruz F, et al. Is the urothelium intelligent ? Neurourol Urodyn 2010; 29: 598-602.
3. Hawthorn MH, Chapple CR, Cock M, et al. Urothelium-derived inhibitory factor(s) influences on detrusor smooth muscle contractility in vitro. Br J Pharmacol 2000; 129: 416-9. (Pubitemid 30083861)
4. Chaiyaprasithi B, Mang CF, Kilbinger H, et al. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003; 170: 1897-900. (Pubitemid 37254955)
5. Azadzoi KM, Heim VK, Tarcan T, et al. Alteration of urothelial-mediated tone in the ischemic bladder: Role of eicosanoids. Neurourol Urodyn 2004; 23: 258-64. (Pubitemid 39549987)
6. Murakami S, Chapple CR, Akino H, et al. The role of the urothelium in mediating bladder responses to isoprenaline. BJU Int 2007; 99: 669-73. (Pubitemid 46238848)
7. 3- adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome. Neurourol Urodyn 2010; 29: 1320-1325.
8. Santoso AGH, Sonarno IAB, Arsad NAB, et al. The role of the urothelium and ATP in mediating detrusor smooth muscle contractility. Urology 2010 (in press). DOI: 10.1016/j.urology.2010.06.040.
9. Truss MC, Ückert S, Stief CG, et al. Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. Urol Res 1996; 24: 129-34.
10. Andersson K-E, Gratzke C,. Bladder pharmacology and treatment of lower urinary tract symptoms: Recent advances. UroToday Int J 2008; 1. DOI: 3834/uij.1939-4810.2008.07.06.
11. Yanai Y, Hashitani H, Hayase M, et al. Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder. Neurourol Urodyn 2008; 27: 446-53. (Pubitemid 351991212)
12. Maggi CA, Evangelista S, Grimaldi G, et al. Evidence for the involvement of arachidonic acid metabolite in spontaneous and drug-induced contractions of rat urinary bladder. J Pharmacol Exp Ther 1984; 230: 500-13. (Pubitemid 14061635)
13. Lecci A, Birder LA, Meini S, et al. Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats. Br J Pharmacol 2000; 130: 331-8. (Pubitemid 30261043)
14. Angelico P, Guarneri L, Velasco C, et al. Effect of cyclooxygenase inhibitors on the micturition reflex in rats: Correlation with inhibition of cylooxygenase isozymes. BJU Int 2006; 97: 837-46. (Pubitemid 43383525)
15. Pagala MK, Tetsoti L, Nagpal D, et al. Aging effects on contractility of longitudinal and circular detrusor and trigone of rat bladder. J Urol 2001; 166: 721-7. (Pubitemid 32652307)
16. + channels increases contractility more in transverse than in longitudinal rat detrusor strips. Urology 2009; 73: 400-4.
17. Liang W, Lo WN,. β-Adrenoceptor-mediated differences in transverse and longitudinal strips from the rat detrusor. Int Urol Nephrol 2010 (in press). DOI: 10.1007/s11255-010-9759-y.
18. Fathian-Sabet B, Bloch W, Klotz T, et al. Localization of constitutive nitric oxide synthase isoforms and the nitric oxide target enzyme soluble guanylyl cyclase in the human bladder. J Urol 2001; 165: 1724-9. (Pubitemid 32410297)
19. Gillespie JI, Markerink-van Ittersum M, de Vente J,. Expression of neuronal nitric oxide synthase (nNOS) and nitric-oxide-induced changes in cGMP in the urothelial layer of the guinea pig bladder. Cell Tissue Res 2005; 321: 341-51. (Pubitemid 41206988)
20. de Jongh R, van Koeveringe GA, van Kerrebroeck EV, et al. The effects of exogenous prostaglandins and the identification of constitutive cyclooxygenase I and II immunoreactivity in the normal guinea pig bladder. BJU Int 2007; 100: 419-29. (Pubitemid 47036590)
21. Wang ZY, Wang P, Bjorling DE,. Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells. Am J Physiol Regul Integr Comp Physiol 2009; 297: R1127-35.
22. Brading AF,. Spontaneous activity of lower urinary tract smooth muscles: Correlation between ion channels and tissue function. J Physiol 2006; 570: 13-22.
23. 3-adrenoceptor- mediated relaxation, causing rat detrusor overactivity. Br J Pharmacol 2008; 153: 1659-68. (Pubitemid 351545807)
24. Lagou M, Drake MJ, Markerink-van Ittersum M, et al. Interstitial cells and phasic activity in the isolated mouse bladder. BJU Int 2006; 98: 643-50. (Pubitemid 44185892)
25. Oger S, Behr-Roussel D, Gorny D, et al. Relaxation of phasic contractile activity of human detrusor strips by cyclic nucleotide phosphodiesterase type 4 inhibition. Eur Urol 2007; 51: 772-81. (Pubitemid 46097278)