Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. II. Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro

Urological Research

Volumn 24, Issue 3, 1996, Pages 129-134

  Truss, M C ^a,b   Uckert S ^a,b   Stief, C G ^a   Forssmann, W G ^a   Jonas, U ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IPF PHARMACEUTICALS GMBH   (Germany)

Author keywords

cAMP; cGMP; Detrusor; Phospodiesterase

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPYRIDAMOLE; FORSKOLIN; ISOENZYME; MILRINONE; NITROPRUSSIDE SODIUM; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG; VINPOCETINE; ZAPRINAST; ZK 67211;

ARTICLE; DETRUSOR MUSCLE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MUSCLE RELAXATION; MUSCLE TONE; PRIORITY JOURNAL;

CYCLIC AMP; CYCLIC GMP; HUMANS; ISOENZYMES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; URINARY BLADDER;

EID: 0029947744     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00304075     Document Type: Article

References (18)

1. Arnold JM (1993) The role of phosphodiesterase inhibitors in heart failure. Pharmacol Ther 57:161
2. Beavo J (1990) Multiple phosphodiesterase isoenzymes: background, nomenclature and implications. In: Beavo J, Houslay HM (eds) Cyclic nucleotide phosphodiesterases: structure, regulation and drug action. Wiley, Chichester, p 3
3. Conti M, Setnikar I (1975) Flavoxate, a potent phosphodiesterase inhibitor. Arch Int Pharmacodyn 213:186
4. Hagiwara M, Endo T, Hidaka H (1984) Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem Pharmacol 33(3):453
5. Hardman JG (1984) Cyclic nucleotides and regulation of vascular smooth muscle. J Cardiovasc Pharmacol 6:639
6. Lincoln TM (1989) Cyclic CMP and mechanisms of vasodilation. Pharmacol Ther 41:479
7. Lowry OH, Rosebrough H, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:165
8. Morita T, Tsujii T, Dokita S (1992) Regional difference in functional roles of cAMP and cGMP in lower urinary tract smooth muscle contractility. Urol Int 49:191
9. Nicholson CD, Shahid M (1994) Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma. Pulm Pharmacol 7:1
10. Nicholson CD, Challiss RA, Shahid M (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 12:19-27
11. Nosálová V, Machová J, Babulová A (1993) Protective action of vinpocetine against experimentally induced gastric damage in rats. Arzneimittel forschung 43(II):891
12. Persson K, Anderson KE (1992) Nitric oxide and relaxation of pig lower urinary tract. Br J Pharmacol 106:416
13. Persson K, Igawa Y, Mattiasson A, Andersson KE (1992) Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro. Br J Pharmacol 107:178
14. Pharmacia (1991) Dridase (oxybutynin) product information. Pharmacia, Erlangen, 49
15. Schoeffter P, Lugnier C, Demesy WF, Stoclet JC (1987) Role of cyclic AMP- and cyclic GMP-phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta. A study with selective inhibitors. Biochem Pharmacol 36:3965
16. Vegesna RV, Diamond J (1983) Comparison of the effects of forskolin and isoproterenol on cyclic AMP levels and tension in bovine coronary artery. Can J Physiol Pharmacol 61:1202
17. Vegesna RV, Diamond J (1986) Elevation of cyclic AMP by prostacyclin is accompanied by relaxation of bovine coronary arteries and contraction of rabbit aortic rings. Eur J Pharmacol 128:25
18. Zhou HL, Torphy TJ (1991) Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators. J Pharmacol Exp Ther 258:972