A model of a MAPK•substrate complex in an active conformation: A computational and experimental approach

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Lee, Sunbae ^a   Warthaka, Mangalika ^a   Yan, Chunli ^b   Kaoud, Tamer S ^a   Piserchio, Andrea ^c   Ghose, Ranajeet ^c,d   Ren, Pengyu ^a,b   Dalby, Kevin N ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The University of Texas at Austin   (United States)

^c CITY COLLEGE OF NEW YORK   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR ETS 1; LIGAND; PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; COMPETITIVE INHIBITION; COMPLEX FORMATION; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; ANIMAL; BIOCATALYSIS; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MOUSE; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; LIGANDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEIN C-ETS-1; SUBSTRATE SPECIFICITY;

EID: 79954524705     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018594     Document Type: Article

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