Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic activity in the rat detrusor

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 3, Issue 1, 2011, Pages 29-37

  Teong, Ivy Wen Jia ^a   Ko, Amy An Ru ^a   Li, Minghao ^b   Heese, Klaus ^a,b   Liang, Willmann ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Contraction; Detrusor; Gastrodia elata; Phasic activity; Relaxation; Tianma; Urothelium

Indexed keywords

CARBACHOL; GASTRODIA ELATA EXTRACT; ISOPRENALINE; POTASSIUM ION;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFECT; GASTRODIA ELATA; MALE; MUSCLE POTENTIAL; MUSCLE RELAXATION; NONHUMAN; RAT; SMOOTH MUSCLE; UROTHELIUM;

EID: 79954504209     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Michel MC, Barendrecht MM. Physiological and pathological regulation of the autonomic control of urinary bladder contractility. Pharmacol Ther 2008; 117:297-312.
2. Brading AF. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol 2006; 570: 13-22.
3. Fry CH, Meng E, Young JS. The physiological function of lower urinary tract smooth muscle. Auton Neurosci 2010; 154:3-13.
4. Chen JK, Chen TT. Tian ma. Chinese medical herbology and pharmacology. Edited by Crampton L. Art of Medicine Press, City of Industry, 2004, pp 785-787.
5. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D. Prevalence of hypertension in the US adult population. Hypertension 1995; 25: 305-313.
6. Chang H-M, But P P-H. Tianma and mihuanjun. Pharmacology and applicaions of Chinese Materia Medica. Edited by Chang H-M, But P P-H. World Scientific, New Jersey, 1986, pp 171-174.
7. Hayashi J, Sekine T, Deguchi S, Lin Q, Horie S, Tsuchiya S, Yano S, Watanabe K, Ikegami F. Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochem 2002; 59: 513-519.
8. Li N, Wang K-J, Chen J-J, Zhou J. Phenolic compounds from the rhizomes of Gastrodia elata. J Asian Nat Prod Res 2007; 9: 373-377.
9. Lo WN, Liang W. Blockade of voltage-sensitive K+ channels increases contractility more in transverse than in longitudinal rat detrusor strips. Urology 2009; 73:400-404.
10. Chaiyaprasithi B, Mang CF, Kilbinger H, Hohenfellner M. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003; 170: 1897-1900.
11. Hawthorn MH, Chapple CR, Cock M, Chess-Williams. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000; 129: 416-419.
12. Santoso AGH, Sonarno IAB, Arsad NAB, Liang W. The role of the urothelium and ATP in mediating detrusor smooth muscle contractility. Urology 2010; doi:10.1016/j.urology.2010.06.040.
13. Frazier EP, Schneider T, Michel MC. Effects of gender, age and hypertension on b-adrenergic receptor function in rat urinary bladder. Naunyn Schmiedebergs Arch Pharmacol 2006; 373: 300-309.
14. 3-adrenoceptors in mouse urinary bladder function: role in detrusor muscle relaxation and micturition reflex. Eur J Pharmacol 2009; 618: 76-83.
15. Liang W, Lo WN. b-adrenoceptor-mediated differences in transverse and longitudinal strips from the rat detrusor. Int Urol Nephrol 2010; doi:10.1007/s11255-010-9759-y.
16. + channel blockade. UroToday Int J 2010; doi:10.3834/uij.1944-5784.2010.04.07.
17. Pagala MK, Tetsoti L, Nagpal D, Wise GJ. Aging effects on contractility of longitudinal and circular detrusor and trigone of rat bladder. J Urol 2001; 166:721-727.
18. Szigeti GP, Somogyi GT, Csernoch L, Széll E. Age-dependence of the spontaneous activity of the rat urinary bladder. J Muscle Res Cell Motil 2005; 26:23-29.
19. Santoso AGH, Lo WN, Liang W. Urotheliumdependent and urothelium-independent detrusor contractility mediated by nitric oxide synthase and cyclooxygenase inhibition. Neurourol Urodynam 2010; doi:10.1002/nau.21015.
20. Azadzoi KM, Heim VK, Tarcan T, Siroky MB. Alteration of urothelial-mediated tone in the ischemic bladder: role of eicosanoids. Neurourol Urodynam 2004; 23: 258-264.