A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 32, Issue 8, 2010, Pages 557-564

  Wiskur, Brandt Justin ^a   Tyler, K ^a   Campbell Dittmeyer, K ^b   Chaplan, S R ^c   Wickenden, A D ^c   van Meerveld, Greenwood B ^a,b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; ACETIC ACID; TRINITROBENZENESULFONIC ACID; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC INFLAMMATION; COLON DILATATION; COLON DISEASE; COLON HYPERSENSITIVITY; CONTROLLED STUDY; DESCENDING COLON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; MALE; NONHUMAN; RAT;

ACETIC ACID; ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; COLON; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; IRRITABLE BOWEL SYNDROME; MALE; PIPERAZINES; RATS; RATS, WISTAR; TRINITROBENZENESULFONIC ACID; TRPV CATION CHANNELS;

EID: 79954469943     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2010.32.8.1507853     Document Type: Article

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