Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 1 36-1, 1997, Pages

  Plourde, Victor ^a   St Pierre, Serge ^a   Quirion, Rémi ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Afferent nerve sensitization; Visceral afferents

Indexed keywords

ACETIC ACID; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE[8-37];

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLIC; COLON DILATATION; CONTROLLED STUDY; HUMAN; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECTUM; SENSITIZATION; VISCERAL PAIN;

EID: 0030760906     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.1.g191     Document Type: Article

References (32)

1. Amara, S. G., L. I. Arriza, L. W. Swanson, R. M. Evans, and M. G. Rosenfeld. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science 229: 1094-1097, 1985.
2. Amara, S. G., V. Jonas, M. G. Rosenfeld, E. S. Ong, and R. M. Evans. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 296: 240-244, 1982.
3. Bradette, M., M. Delvaux, G. Staumont, J. Fioramonti, L. Bueno, and J. Frexinos. Evaluation of colonic sensory thresholds in IBS patients using a barostat. Dig. Dis. Sci. 39: 449-457, 1994.
4. Cervero, F. Visceral nociception: peripheral and central aspects of visceral nociceptive systems. Philos. Trans. R. Soc. Lond. B Biol. Sci. 308: 325-337, 1985.
5. Cervero, F., and A. Iggo. The substantia gelantinosa of the spinal cord. Brain 103: 717-772, 1980.
6. Chung, K., W. T. Lee, and M. J. Park. Spinal projections of pelvic visceral afferents of the rat: a calcitonin gene-related peptide (CGRP) immunohistochemical study. J. Comp. Neurol. 337: 63-69, 1993.
7. Clague, J. R., C. Sternini, and N. C. Brecha. Localization of calcitonin gene-related peptide-like immunoreactivity in neurons of the rat gastrointestinal tract. Neurosci. Lett. 56: 63-68, 1985.
8. Delree, P., D. Martin, C. Sadzot-Delvaux, B. Rogister, P. Leprince, P. Robe, J. M. Rigo, P. P. Lefebvre, B. Malgrance, J. Schoenen, and G. Moonen. In vitro and in vivo modulation of 5-hydroxytryptamine-, thyrotropin-releasing hormone- and calcitonin-gene related peptide-like immunoreactivities in adult rat sensory neurons. Neuroscience 51: 401-410, 1992.
9. Dennis, T., A. Fournier, A. Cadieux, F. Pomerleau, F. B. Jolicoeur, S. St. Pierre, and R. Quirion. hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J. Pharmacol. Exp. Ther. 254: 123-127, 1990.
10. 1 receptor subtype in the vascular system in the rat: studies with hCGRP fragments and analogs. Peptides 11: 885-889, 1990.
11. Green, T., and G. J. Dockray. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea pig. Neuroscience 25: 181-193, 1988.
12. Grundy, D. Speculation on the structure/function relationship for vagal and splanchnic afferent endings supplying the gastrointestinal tract. J. Auton. Nerv. Syst. 22: 175-180, 1988.
13. Holzer, P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neurotransmitters. Neuroscience 24: 739-768, 1988.
14. Jaenig, W., and J. F. B. Morrison. Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception. In: Progress in Brain Research, edited by F. Cervero and J. F. B. Morrison. New York: Elsevier, 1986, p. 87-114.
15. Julia, V., O. Morteau, and L. Bueno. Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats. Gastroenterology 107: 94-102, 1994.
16. Kawamura, M., Y. Kuraishi, M. Minami, and M. Satoh. Antinociceptive effect of intrathecally administered antiserum against calcitonin gene-related peptide on thermal and mechanical noxious stimuli in experimental hyperalgesic rats. Brain Res. 497: 199-203, 1989.
17. Langlois, A., L. Diop, P. J. M. Riviere, D. Pascaud, and J. L. Junien. Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat. Eur. J. Pharmacol. 271: 245-251, 1994.
18. Lembo, T., J. Munakata, H. Mertz, N. Niazi, A. Kodner, V. Nikas, and E. A. Mayer. Evidence for the hypersensitivity of lumhar splanchnic afferents in irritable bowel syndrome. Gastroenterology 107: 1686-1696, 1994.
19. Martinez, V., L. Wang, J. C. Marvizon, and Y. Taché. Distension of the proximal colon induces fos in the central nervous system in conscious rats: role of capsaicin-sensitive afferents (Abstract). Gastroenterology 108: A644, 1995.
20. Mertz, H., B. Naliboff, J. Munakata, N. Niazi, and E. A. Mayer. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 109: 40-52, 1995.
21. Ness, T. J., and G. F. Gebhart. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudoaffective reflexes in the rat. Brain Res. 450: 153-169, 1988.
22. Ness, T. J., and G. F. Gebhart. Visceral pain: a review of experimental studies. Pain 41: 167-234, 1990.
23. 2 receptors in a spinal nociceptive reflex in the rat. Eur. J. Pharmacol. 232: 255-261, 1993.
24. Plourde, V., H. Mertz, L. Fefer, A. Kodner, B. Sytnik, Y. Tache, and E. Mayer. Anorectal sensory and motor responses to rectal distension in humans (Abstract). Hell. J. Gastroenterol. 5: 286, 1992.
25. Plourde, V., S. St.-Pierre, A. Fournier, and Y. Tache. CGRP 8-37 blocks the inhibition of gastric emptying induced by intravenous injection of α-CGRP in rats. Life Sci. 52: 857-862, 1992.
26. Raybould, H. E. Inhibitory effects of calcitonin gene-related peptide on gastrointestinal motility. Ann. NY Acad. Sci. 657: 248-257, 1992.
27. Ritchie, J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 14: 125-132, 1973.
28. Sharkey, K. A., H. Sobrino, A. F. Cervero, A. Varro, and G. J. Dockray. Visceral and somatic afferent origin of CGRP in the lower thoracic spinal cord of the rat. Neuroscience 32: 169-179, 1989.
29. Sternini, C., J. R. Reeve, Jr., and N. Brecha. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology 93: 852-862, 1987.
30. Whitehead, W. E., B. Holtkotter, P. Enck, R. Hoelzl, K. D. Holmes, J. Anthony, H. Shabsin, and M. M. Schuster. Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 98: 1187-1192, 1990.
31. Woolf, C., and Z. Wiesenfeld-Hallin. Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat. Neurosci. Lett. 66: 226-230, 1986.
32. Yaksh, T. L., R. Y. Noueihed, and P. A. C. Durant. Studies of the pharmacology and pathology of intrathecally administered 4-anilinopiperidine analogues and morphine in the rat and cat. Anesthesiology 64: 54-66, 1986.