Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients

Molecular Genetics and Metabolism

Volumn 88, Issue 2, 2006, Pages 196-198

  Petit, Jean Michel ^a   Masson, David ^a   Minello, Anne ^a   Duvillard, Laurence ^a   Galland, Francoise ^a   Verges, Bruno ^a   Gambert, Philippe ^a   Hillon, Patrick ^a  

^a HÔPITAL DU BOCAGE   (France)

Author keywords

Fatty acid; Fibrosis; HCV; Hepatitis C; Microsomal triglyceride transfer protein; Steatosis

Indexed keywords

MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DNA POLYMORPHISM; FATTY LIVER; FEMALE; GENE EXPRESSION; GENOTYPE; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; VIRUS INFECTION;

ADULT; BODY MASS INDEX; CARRIER PROTEINS; FATTY LIVER; FEMALE; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; VIRAL CORE PROTEINS;

HEPATITIS C VIRUS;

EID: 33646387993     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2005.12.006     Document Type: Article

References (9)

1. Lonardo A., Adinolfi L.E., Loria P., Carulli N., and Ruggiero G. Day CP Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 126 (2004) 586-597
2. Agnello V., Abel G., Elfahal M., Knight G.B., and Zhang Q.X. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA 96 (1999) 12766-12771
3. Petit J.M., Benichou M., Duvillard L., Jooste V., Bour J.B., Minello A., Verges B., Brun J.M., Gambert P., and Hillon P. HCV-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis and liver fibrosis. Am. J. Gastroenterol. 98 (2003) 1150-1154
4. Favre D., and Muellhaupt B. Potential cellular receptors involved in hepatitis C virus entry into cells. Lipids Health Dis. 4 (2005) 9
5. Perlemuter G., Sabile A., Letteron P., Vona G., Topilco A., Chretien Y., Koike K., Pessayre D., Chapman J., Barba G., and Brechot C. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J. 16 (2002) 185-194
6. Karpe F., Lundahl B., Ehrenborg E., Eriksson P., and Hamsten A. A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 756-761
7. Bernard S., Touzet S., Personne I., Lapras V., Bondon P.J., Berthezene F., and Moulin P. Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes. Diabetologia 43 (2000) 995-999
8. Raabe M., Veniant M.M., Sullivan M.A., Zlot C.H., Bjorkegren J., Nielsen L.B., Wong J.S., Hamilton R.L., and Young S.G. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J. Clin. Invest. 103 (1999) 1287-1298
9. Namikawa C., Shu-Ping Z., Vyselaar J.R., Nozaki Y., Nemoto Y., Ono M., Akisawa N., Saibara T., Hiroi M., Enzan H., and Onishi S. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J. Hepatol. 40 (2004) 781-786