Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers

European Journal of Clinical Pharmacology

Volumn 67, Issue 3, 2011, Pages 267-275

  Fortin, Anny ^a   Verbeeck, Roger K ^b,c   Jansen, Frans H ^a  

^a Dafra Pharma International   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c RHODES UNIVERSITY   (South Africa)

Author keywords

Amodiaquine; Artesunate; Bioequivalence; Fixed dose non fixed combination; Healthy male volunteers; Pharmacokinetics; Tolerability

Indexed keywords

AMODIAQUINE; AMODIAQUINE PLUS ARTESUNATE; AMONATE; ARSUAMOON; ARTESUNATE; DEETHYLAMODIAQUINE; DIHYDROARTEMISININ; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG TOLERABILITY; HUMAN; HUMAN EXPERIMENT; INDIAN; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AMODIAQUINE; ANALYSIS OF VARIANCE; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; HUMANS; INDIA; MALE; MIDDLE AGED; TABLETS; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 79954448368     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0911-5     Document Type: Article

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