Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

European Journal of Clinical Pharmacology

Volumn 65, Issue 8, 2009, Pages 809-821

  Navaratnam, Visweswaran ^a   Ramanathan, Surash ^a   Wahab, Mohd Suhaimi Ab ^b   Siew Hua, Gan ^b   Mansor, Sharif Mahsufi ^a   Kiechel, Jean René ^c   Vaillant, Michel ^d,e   Taylor, Walter R J ^f   Olliaro, Piero ^g  

^a SCHOOL OF PHYSICS   (Malaysia)

^b HOSPITAL UNIVERSITI SAINS MALAYSIA   (Malaysia)

^c DND i (Drugs for Neglected Diseases Initiative)   (Switzerland)

^d Public Research Centre Health   (Germany)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^g WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Amodiaquine; Artesunate; Fixed combination treatment; Non fixed combination treatment; Pharmacokinetics; Tolerability

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMODIAQUINE; AMODIAQUINE PLUS ARTESUNATE; ARTESUNATE; ASPARTATE AMINOTRANSFERASE; CALCIUM ION; CREATININE; DEETHYLAMODIAQUINE; DIHYDROARTEMISININ; FLAVOQUIN; HEMOGLOBIN; POTASSIUM ION; SODIUM ION; UNCLASSIFIED DRUG; URIC ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOEQUIVALENCE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG METABOLISM; DRUG TOLERABILITY; ELECTROCHEMICAL DETECTION; ERYTHROCYTE COUNT; FEMALE; FLUSHING; GASTROINTESTINAL SYMPTOM; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYPOCALCEMIA; HYPONATREMIA; LEUKOCYTE COUNT; MALAYSIA; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NAUSEA; NEUTROPENIA; NEUTROPHIL COUNT; NORMAL HUMAN; OPEN STUDY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; THROMBOCYTE COUNT; TIME TO MAXIMUM PLASMA CONCENTRATION; URIC ACID BLOOD LEVEL;

EID: 70349595536     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0656-1     Document Type: Article

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