Lactase gene C/T-13910 polymorphism, calcium intake, and pQCT bone traits in finnish adults

Calcified Tissue International

Volumn 88, Issue 2, 2011, Pages 153-161

  Tolonen, Sanna ^a   Laaksonen, Marika ^a   Mikkilä, Vera ^a   Sievänen, Harri ^b   Mononen, Nina ^c   Räsänen, Leena ^a   Viikari, Jorma ^d   Raitakari, Olli T ^d   Kähönen, Mika ^c   Lehtimäki, Terho J ^c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UKK INSTITUTE FOR HEALTH PROMOTION RESEARCH   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

C T 13910 polymorphism; Calcium; Peripheral quantitative computed tomography; Radius; Tibia

Indexed keywords

LACTASE;

ADULT; ARTICLE; BONE STRUCTURE; CALCIUM INTAKE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIET; FEMALE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN EXPERIMENT; LIFESTYLE; MALE; NORMAL HUMAN; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ADULT; BONE DENSITY; CALCIUM, DIETARY; CARDIOVASCULAR DISEASES; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FINLAND; FRACTURES, BONE; GENOTYPE; HUMANS; LACTASE; LACTOSE INTOLERANCE; MALE; POLYMORPHISM, GENETIC; RISK; TIBIA; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79954429496     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9440-6     Document Type: Article

References (43)

1. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002) Identification of a variant associated with adulttype hypolactasia. Nat Genet 30:233-237
2. Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Järvelä I (2003) Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 52:647-652 (Pubitemid 36528864)
3. Sahi T (1994) Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 202 (Suppl): 7-20 (Pubitemid 24128390)
4. Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL (2004) A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 53:1571-1576 (Pubitemid 39434096)
5. Obermayer-Pietsch BM, Bonelli CM, Walter DE, Kuhn RJ, Fahrleitner-Pammer A, Berghold A, Goessler W, Stepan V, Dobnig H, Leg G, Renner W (2004) Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 19:42-47 (Pubitemid 41295136)
6. Lehtimäki T, Hemminki J, Rontu R, Mikkilä V, Räsänen L, Laaksonen M, Hutri-Kähönen N, Kähönen M, Viikari J, Raitakari O (2006) The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study. The Cardiovascular Risk in Young Finns Study. Pediatrics 118:1553-1559 (Pubitemid 46393801)
7. Laaksonen MM, Mikkilä V, Räsänen L, Rontu R, Lehtimäki TJ, Viikari JS, Raitakari OT, Cardiovascular Risk in Young Finns Study Group (2009) Genetic lactase non-persistence, consumption of milk products and intakes of milk nutrients in Finns from childhood to young adulthood. Br J Nutr 102:8-17
8. Enattah NS, Sulkava R, Halonen P, Kontula K, Järvelä I (2005) Genetic variant of lactase-persistent C/T-13910 is associated with bone fractures in very old age. J Am Geriatr Soc 53:79-82 (Pubitemid 41647635)
9. Obermayer-Pietsch BM, Gugatschka M, Reitter S, Plank W, Strele A, Walter D, Bonelli C, Goessler W, Dobnig H, Högenauer C, Renner W, Fahrleitner-Pammer A (2007) Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption? Osteoporos Int 18:445-451 (Pubitemid 46354914)
10. Bàcsi K, Kòsa JP, Lazàry A, Balla B, Horvàth H, Kis A, Nagy Z, Takàcs I, Lakatos P, Speer G (2009) LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women. Osteoporos Int 20:639-645
11. Enattah N, Välimäki VV, Välimäki MJ, Löyttyniemi E, Sahi T, Järvelä I (2004) Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young Finnish men. Calcif Tissue Int 75:488-493 (Pubitemid 40174507)
12. Enattah N, Pekkarinen T, Välimäki MJ, Löyttyniemi E, Järvelä I (2005) Genetically defined adult-type hypolactasia and selfreported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. Eur J Clin Nutr 59:1105-1111 (Pubitemid 41508656)
13. Gugatschka M, Hoeller A, Fahrleitner-Pammer A, Dobnig H, Pietschmann P, Kudlacek S, Obermayer-Pietsch B (2007) Calcium supply, bone mineral density and genetically defined lactose maldigestion in a cohort of elderly men. J Endocrinol Invest 30:46-51 (Pubitemid 46470383)
14. Laaksonen MM, Impivaara O, Sievänen H, Viikari JS, Lehtimäki TJ, Lamberg-Allardt CJ, Kärkkäinen MU, Välimäki M, Heikkinen J, Kröger LM, Kröger HP, Jurvelin JS, Kähönen MA, Raitakari OT, Cardiovascular Risk in Young Finns Study Group (2009) Associations of genetic lactase non-persistance and sex with bone loss in young adulthood. Bone 44:1003-1009
15. Nordin BEC (1997) Calcium in health and disease. Food Nutr Agric 20:13-26 (Pubitemid 128107906)
16. Välimäki MJ, Kärkkäinen M, Lamberg-Allardt C, Laitinen K, Alhava E, Heikkinen J, Impivaara O, Mäkelä P, Palmgren J, Seppänen R, Vuori I, The Cardiovascular Risk in Young Finns Study Group (1994) Exercise, smoking, and calcium intake during adolescence and early adulthood as determinants of peak bone mass. BMJ 309:230-235 (Pubitemid 24252658)
17. Wang Q, Seeman e (2008) skeletal growth and peak bone strength. Best Pract Res Clin Endocrinol Metab 22:687-700
18. Paturi M, Tapanainen H, Reinivuo H, Pietinen P (2008) The National FINDIET 2007 survey. Publications of National Public Health Institute, Series B, vol B23, p 79
19. Raitakari OT, Juonala M, Rönnemaa T, Keltikangas-Järvinen L, Räsänen L, Pietikäinen M, Hutri-Kähönen N, Taittonen L, Jokinen E, Marniemi J, Jula A, Telama R, Kähönen M, Lehtimäki T, Åkerblom HK, Viikari JS (2008) Cohort profile: the Cardiovascular Risk in Young Finns Study. Int J Epidemiol 37:1220-1226
20. Sievänen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I (1998) Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision. J Bone Miner Res 13:871-882 (Pubitemid 28224204)
21. Kontulainen S, Sievanen H, Kannus P, Pasanen M, Vuori I (2002) Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res 17:2281-2289 (Pubitemid 35416763)
22. Rantalainen T, Sievänen H, Linnamo V, Hoffrèn M, Ishikawa M, Kyröläinen H, Avela J, Selänne H, Komi PV, Heinonen A (2009) Bone rigidity to neuromuscular performance ratio in young and elderly men. Bone 45:956-963
23. Nikander R, Kannus P, Dastidar P, Hannula M, Harrison L, Cervinka T, Narra NG, Aktour R, Arola T, Eskola H, Soimakallio S, Heinonen A, Hyttinen J, Sievänen H (2009) Targeted exercises against hip fragility. Osteoporos Int 20:1321-1328
24. Livak KJ (1999) Allelic discrimination using fluorogenic probes and the 5'nuclease assay. Genet Anal 14:143-149 (Pubitemid 29095371)
25. Laaksonen MML, Sievänen H, Tolonen S, Mikkilä V, Räsänen L, Viikari J, Lehtimäki T, Kähönen M, Raitakari OT, The Cardiovascular Risk in Young Finns Study Group (2010) Determinants of bone strength and fracture incidence in adult Finns: Cardiovascular Risk in Young Finns Study (the GENDI pQCT study). Arch Osteoporos. doi:10.1007/s11657- 010-0043-7
26. Paalanen L, Männistö S, Virtanen MJ (2006) Validity of a food frequency questionnaire varied by age and body mass index. J Clin Epidemiol 59:994-1001 (Pubitemid 44163419)
27. National Institute for Health and Welfare, Nutrition Unit (2009) Fineli. Finnish food composition database. Release 10, Helsinki. http://www.fineli.fi
28. Willett WC (1998) Nutritional epidemiology, 2nd edn. Oxford University Press, New York
29. Raymond M, Rousset F (1995) GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 86:248-249
30. Larson NI, Neumark-Sztainer D, Harnack L, Wall M, Story M, Eisenberg ME (2009) Calcium and dairy intake: longitudinal trends during the transition to young adulthood and correlates of calcium intake. J Nutr Educ Behav 41:254-260
31. Boonen S, Lips P, Bouillon R, Heike A, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92:1415-1423 (Pubitemid 46556419)
32. Tang BMP, Eslick GD, Nowson C, Smith C, Bensoussan A (2007) Use of calcium or calcium in combination with D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 307:657-666 (Pubitemid 47285316)
33. Wizenberg T, Shaw K, Fryer J, Jones G (2006) Effects of calcium supplementation on bone density in healthy children: metaanalysis of randomised controlled trials. BMJ 333:775
34. Huncharek M, Muscat J, Kupelnick B (2008) Impact of dairy products and dietary calcium on bone-mineral content in children: results of a meta-analysis. Bone 43:312-321
35. Matkovic V, Heaney RP (1992) Calcium balance during human growth: evidence for threshold behaviour. Am J Clin Nutr 55:992-996
36. Weaver CM, Martin BR, Plawecki KL (1995) Differences in calcium metabolism between adolescent and adult females. Am J Clin Nutr 61:577-581
37. Kettunen J, Silander K, Saarela O, Amin N, Müller M, Timpson N, Surakka I, Ripatti S, Laitinen J, Hartikainen AL, Pouta A, Lahermo P, Anttila V, Männistö S, Jula A, Virtamo J, Salomaa V, Lehtimäki T, Raitakari O, Gieger C, Wichmann EH, Van Duijn CM, Smith GD, McCarthy MI, Järvelin MR, Perola M, Peltonen L (2010) European lactase persistence genotype shows evidence of association with increase in body mass index. Hum Mol Genet 19:1129-1136
38. Sievänen H (2005) Hormonal influences on the muscle-bone feedback system: a perspective. J Musculoskelet Neuronal Interact 5:255-261 (Pubitemid 41684174)
39. Sievänen H (2000) A physical model for dual-energy X-ray absorptiometry-derived bone mineral density. Invest Radiol 35:325-330 (Pubitemid 30395316)
40. Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM (2008) Clinical use of quantitative computed tomography and peripheral quantitative computed in the managment of osteoporosis in adults: the 2007 ISCD official positions. J Clin Densitom 11:123-162 (Pubitemid 351602191)
41. Vico L, Zouch M, Amirouche A, Frère D, Laroche N, Koller B, Laib A, Thomas T, Alexandre C (2008) High-resolution pQCT analysis at the distal radius and tibia discriminated patients with recent wrist and femoral neck fractures. J Bone Miner Res 23:1741-1750
42. Kontulainen SA, Johnston JD, Liu D, Leung C, Oxland TR, McKay HA (2008) Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis. J Musculoskelet Neuronal Interact 8:401-409
43. Uusi-Rasi K, Sievänen H, Pasanen M, Oja P, Vuori I (2002) Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: a peripheral quantitative computed tomography study. J Bone Miner Res 17:544-552 (Pubitemid 34171770)