Hypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: A prospective trial

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 1, 2011, Pages 148-153

  Bakst, Richard L ^a   Lee, Nancy ^a   Pfister, David G ^a   Zelefsky, Michael J ^a   Hunt, Margie A ^a   Kraus, Dennis H ^a   Wolden, Suzanne L ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Dose painting; Hypofractionated; Intensity modulated radiation therapy; Nasopharyngeal cancer

Indexed keywords

DISTANT METASTASIS; DOSE-PAINTING; GROSS TUMOR VOLUME; HEARING LOSS; HYPOFRACTIONATED; IN-FIELD; INTENSITY-MODULATED RADIATION THERAPY; LOCAL CONTROL; LOW RATES; MEAN DOSE; NASOPHARYNGEAL CANCER; NASOPHARYNGEAL CARCINOMA; OTOTOXICITY; OVERALL SURVIVAL; RADIATION NECROSIS; SURGICAL RESECTION; TEMPORAL LOBES; TOXICITY REDUCTION; TUMOR BED; WORLD HEALTH ORGANIZATION;

AUDITION; CHEMOTHERAPY; DISEASES; HEALTH RISKS; PATHOLOGY; RADIOTHERAPY; TUMORS;

PHYSICAL THERAPY;

CARBOPLATIN; CISPLATIN; FLUOROURACIL;

ADULT; ARTICLE; BRAIN NECROSIS; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTINUOUS INFUSION; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HEARING LOSS; HUMAN; HYPOFRACTIONATED DOSE PAINTING INTENSITY MODULATED RADIATION THERAPY; INTENSITY MODULATED RADIATION THERAPY; MALE; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION NECROSIS; TEMPORAL LOBE;

BRAIN; CHEMOTHERAPY, ADJUVANT; COCHLEA; DOSE FRACTIONATION; FEASIBILITY STUDIES; FEMALE; HEARING; HUMANS; LYMPHATIC IRRADIATION; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NECROSIS; NEOPLASM STAGING; PROSPECTIVE STUDIES; RADIATION INJURIES; RADIOTHERAPY, INTENSITY-MODULATED; TUMOR BURDEN; XEROSTOMIA;

EID: 79954420340     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.01.026     Document Type: Article

References (30)

1. A.M. Chu, M.B. Flynn, and E. Achino Irradiation of nasopharyngeal carcinoma: Correlations with treatment factors and stage Int J Radiat Oncol Biol Phys 10 1984 2241 2249 (Pubitemid 15197518)
2. R.T. Hoppe, D.R. Goffinet, and M.A. Bagshaw Carcinoma of the nasopharynx. Eighteen years' experience with megavoltage radiation therapy Cancer 37 1976 2605 2612
3. J.B. Mesic, G.H. Fletcher, and H. Goepfert Megavoltage irradiation of epithelial tumors of the nasopharynx Int J Radiat Oncol Biol Phys 7 1981 447 453 (Pubitemid 11112797)
4. J.W. Bailet, R.J. Mark, and E. Abemayor Nasopharyngeal carcinoma: Treatment results with primary radiation therapy Laryngoscope 102 1992 965 972
5. A.W. Lee, S.Y. Tung, and A.T. Chan Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 66 2006 142 151 (Pubitemid 44175659)
6. A.W. Lee, W.H. Lau, and S.Y. Tung Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group J Clin Oncol 23 2005 6966 6975
7. A.W. Lee, W.M. Sze, and J.S. Au Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience Int J Radiat Oncol Biol Phys 61 2005 1107 1116 (Pubitemid 40340904)
8. J. Wee, E.H. Tan, and B.C. Tai Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety J Clin Oncol 23 2005 6730 6738 (Pubitemid 46190268)
9. M. Al-Sarraf, M. LeBlanc, and P.G. Giri Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099 J Clin Oncol 16 1998 1310 1317 (Pubitemid 28175745)
10. J.E. Marks, J.M. Bedwinek, and F. Lee Dose-response analysis for nasopharyngeal carcinoma: An historical perspective Cancer 50 1982 1042 1050 (Pubitemid 12062879)
11. B. Vikram, U.B. Mishra, and E.W. Strong Patterns of failure in carcinoma of the nasopharynx: I. Failure at the primary site Int J Radiat Oncol Biol Phys 11 1985 1455 1459 (Pubitemid 15033571)
12. S.L. Wolden, M.J. Zelefsky, and M.A. Hunt Failure of a 3D conformal boost to improve radiotherapy for nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 49 2001 1229 1234 (Pubitemid 32294301)
13. P. Xia, K.K. Fu, and G.W. Wong Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 48 2000 329 337
14. M.K. Kam, R.M. Chau, and J. Suen Intensity-modulated radiotherapy in nasopharyngeal carcinoma: Dosimetric advantage over conventional plans and feasibility of dose escalation Int J Radiat Oncol Biol Phys 56 2003 145 157 (Pubitemid 36403686)
15. N. Lee, P. Xia, and J.M. Quivey Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience Int J Radiat Oncol Biol Phys 53 2002 12 22 (Pubitemid 34465802)
16. S.L. Wolden, W.C. Chen, and D.G. Pfister Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-Kettering experience Int J Radiat Oncol Biol Phys 64 2006 57 62 (Pubitemid 41831209)
17. M.K. Kam, S.F. Leung, and B. Zee Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients J Clin Oncol 25 2007 4873 4879 (Pubitemid 350220416)
18. E.H. Pow, D.L. Kwong, and A.S. McMillan Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial Int J Radiat Oncol Biol Phys 66 2006 981 991 (Pubitemid 44633504)
19. P.M. Teo, S.F. Leung, and W.Y. Lee Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma: The existence of a dose-tumor-control relationship above conventional tumoricidal dose Int J Radiat Oncol Biol Phys 46 2000 445 458 (Pubitemid 30067796)
20. W. Hara, B.W. Loo Jr., and D.R. Goffinet Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 71 2008 393 400
21. A. Lauve, M. Morris, and R. Schmidt-Ullrich Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II - clinical results Int J Radiat Oncol Biol Phys 60 2004 374 387 (Pubitemid 39233454)
22. I.D. Fleming, J. Cooper, D.E. Henson, AJCC cancer staging manual 5th ed 1997 Lippincott-Raven Philadelphia
23. J. Williams, Y. Chen, and P. Rubin The biological basis of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 2003 182 188 (Pubitemid 36962642)
24. E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
25. International histological classification of tumors Histological classification of upper respiratory track tumors World Health Organization 19 1978 32
26. K.K. Fu Prognostic factors of carcinoma of the nasopharynx Int J Radiat Oncol Biol Phys 6 1980 523 526 (Pubitemid 10110009)
27. N. Lee, J. Harris, and A.S. Garden Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225 J Clin Oncol 27 2009 3684 3690
28. A.W. Lee, W.T. Ng, and W.M. Hung Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors Int J Radiat Oncol Biol Phys 73 2009 1121 1128
29. J.P. Glass, T.L. Hwang, and M.E. Leavens Cerebral radiation necrosis following treatment of extracranial malignancies Cancer 54 1984 1966 1972 (Pubitemid 14020630)
30. A.W. Lee, D.L. Kwong, and S.F. Leung Factors affecting risk of symptomatic temporal lobe necrosis: significance of fractional dose and treatment time Int J Radiat Oncol Biol Phys 53 2002 75 85 (Pubitemid 34465809)